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Cited by 82Bone health and osteoporosis researchAdrenal and Paraganglionic TumorsHormonal Regulation and Hypertension

Spinal Volumetric Bone Mineral Density and Vertebral Fractures in Female Patients with Adrenal Incidentalomas: The Effects of Subclinical Hypercortisolism and Gonadal Status

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Chiodini, Iacopo, Guglielmi, Giuseppe, Battista, Claudia, Carnevale, Vincenzo, Torlontano, Massimo, Cammisa, Mario, Trischitta, Vincenzo, Scillitani, Alfredo·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-031413
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Abstract

Although adrenal incidentalomas (AI) are not associated with clinically evident syndromes, some patients display biochemical features of subclinical hypercortisolism (SH). Previous studies indicated a negative effect of SH on bone in AI patients, but the prevalence of vertebral fractures and the roles of SH and gonadal status in volumetric bone mineral density are unknown. In 70 female AI patients and 84 controls, the prevalence of vertebral fractures and spinal bone mineral density (by quantitative computed tomography) were evaluated. Subjects were subdivided according to menopausal status into groups Pre (21 patients and 23 controls) and Post (49 patients and 61 controls); there were 14 and 35 patients without SH (SH(-)) and 7 and 14 patients with SH (SH(+)) in groups Pre and Post, respectively. The prevalence of fractures was higher in SH(+) than in controls and in SH(-) subjects in both groups Pre [SH(+), 42.9%; controls, 0% (P = 0.001); SH(-), 7.1% (P = 0.049)] and post [SH(+), 78.6%; controls, 37.7% (P = 0.006); SH(-) 42.9% (P = 0.024)]. In group Post, the mean z-score quantitative computed tomography values were lower in SH(+) patients (-0.78 +/- 0.29) than in controls (0.06 +/- 0.14; P = 0.011) and SH(-) patients (0.02 +/- 0.19; P = 0.034). Evaluation of spinal bone is indicated in female AI patients with SH.

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Authors
Chiodini, I., Guglielmi, G., Battista, C., Carnevale, V., Torlontano, M., Cammisa, M., Trischitta, V., & Scillitani, A.
Affiliations
  • Units of Endocrinology (I.C., C.B., M.T., V.T., A.S.), 71013 S. Giovanni Rotondo (FG), Italy
  • Radiology (G.G., M.C.), 71013 S. Giovanni Rotondo (FG), Italy
  • Casa Sollievo della Sofferenza (IT)
  • Sapienza University of Rome (IT)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-05-01
Volume
89
Issue
5
Pages
2237-2241
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-031413
OpenAlex
W1978334745
Cited by
82
References
30
Citations by year
2025: 3 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 6
FWCI
3.58
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
adrenal incidentaloma, subclinical hypercortisolism, vertebral fractures, spinal bone mineral density, volumetric bone mineral density, menopause, gonadal status, female patients, quantitative computed tomography, bone loss
MeSH terms
Adrenal Gland Neoplasms, Adult, Aged, Female, Humans, Hydrocortisone, Lumbosacral Region, Middle Aged, Ovary, Spine, Bone Density, Prevalence, Spinal Fractures, Incidental Findings

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