The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Molecular mechanisms of the vascular responses to haemodynamic forces
Open accessAbstract
Abstract.: Blood vessels are permanently subjected to mechanical forces in the form of stretch, encompassing cyclic mechanical strain due to the pulsatile nature of blood flow and shear stress. Significant variations in mechanical forces, of physiological or physiopathological nature, occur in vivo. These are accompanied by phenotypical modulation of smooth muscle cells and endothelial cells, producing structural modifications of the arterial wall. In all the cases, vascular remodelling can be allotted to a modification of the tensional strain or shear, and underlie a trend to reestablish baseline mechanical conditions. Vascular cells are equipped with numerous receptors that allow them to detect and respond to the mechanical forces generated by pressure and shear stress. The cytoskeleton and other structural components have an established role in mechanotransduction, being able to transmit and modulate tension within the cell via focal adhesion sites, integrins, cellular junctions and the extracellular matrix. Mechanical forces also initiate complex signal transduction cascades, including nuclear factor‐κ B and mitogen‐activated protein kinase pathways, leading to functional changes within the cell.
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Cites
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Flow-mediated endothelial mechanotransduction
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Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis
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Cited by
Chatzizisis, Y. S., Coskun, A. U., Jonas, M., Edelman, E. R., Feldman, C. L., & Stone, P. H. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.059 · Cited by 1,483
Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
Sallam, N., & Laher, I. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7239639 · Cited by 334
Primary cilia sensitize endothelial cells for fluid shear stress
Hierck, B. P., Van der Heiden, K., Alkemade, F. E., Van de Pas, S., Van Thienen, J. V., Groenendijk, B. C. W., Bax, W. H., Van der Laarse, A., DeRuiter, M. C., Horrevoets, A. J. G., et al. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21472 · Cited by 187
The Effects of Hemodynamic Force on Embryonic Development
CULVER, J. C., & DICKINSON, M. E. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00025.x · Cited by 173
Tomiyama, H., Matsumoto, C., Shiina, K., & Yamashina, A. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.32979 · Cited by 109
Heart Valve Development, Maintenance, and Disease
Tao, G., Kotick, J. D., & Lincoln, J. (2012) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387786-4.00006-3 · Cited by 89
The development of the heart and microcirculation: role of shear stress
Poelmann, R. E., Gittenberger-de Groot, A. C., & Hierck, B. P. (2008) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-008-0304-4 · Cited by 62
Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure
Dongaonkar, R. M., Nguyen, T. L., Quick, C. M., Hardy, J., Laine, G. A., Wilson, E., & Stewart, R. H. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00677.2012 · Cited by 38
Metadata
- Authors
- LEHOUX, S., CASTIER, Y., & TEDGUI, A.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2006-02-23
- Volume
- 259
- Issue
- 4
- Pages
- 381-392
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W1981157406
- Cited by
- 447
- References
- 7
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
