Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors
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Since 2001, brachial-ankle pulse wave velocity (brachial-ankle PWV) measurement has been applied for risk stratification of patients with atherosclerotic cardiovascular disease and/or its risk factors in Japan. Measurement of the brachial-ankle PWV is simple and well standardized, and its reproducibility and accuracy are acceptable. Several cross-sectional studies have demonstrated a significant correlation between the brachial-ankle PWV and known risk factors for cardiovascular disease; the correlation is stronger in subjects with cardiovascular disease than in those without cardiovascular disease. We conducted a meta-analysis, which demonstrated that the brachial-ankle PWV is an independent predictor of future cardiovascular events. Furthermore, the treatment of cardiovascular risk factors and lifestyle modifications have been shown to improve the brachial-ankle PWV. Thus, at present, brachial-ankle PWV is close to being considered as a useful marker in the management of atherosclerotic cardiovascular disease and/or its risk factors.
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Pulse-wave velocity (PWV) produced by cardiac output reflects the stiffness of arteries.
“The pulse-wave velocity (PWV) produced by cardiac output reflects the stiffness of arteries21).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [21]
A baPWV greater than 1,800 cm/s is a risk equivalent to high-risk conditions.
“it is suggested that a baPWV > 1,800 cm/s is a risk that is equivalent to the high-risk conditions18, 21).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [21]
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- Authors
- Tomiyama, H., Matsumoto, C., Shiina, K., & Yamashina, A.
- Affiliations
- Tokyo Medical University (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2016
- Volume
- 23
- Issue
- 2
- Pages
- 128-146
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2296039354
- Cited by
- 109
- References
- 120
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 6 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 9 · 2018: 12 · 2017: 10 · 2016: 5
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- brachial-ankle pulse wave velocity, atherosclerotic cardiovascular disease, cardiovascular risk factors, cardiovascular risk stratification, cardiovascular event prediction, arterial stiffness, cardiovascular risk management, lifestyle modification
- MeSH terms
- Cardiovascular Diseases, Humans, Risk Factors, Severity of Illness Index, Biomarkers, Disease Management, Ankle Brachial Index, Pulse Wave Analysis
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