Cited by 481Stress Responses and CortisolEstrogen and related hormone effectsAdrenal Hormones and Disorders

The coming out of the brain mineralocorticoid receptor

Joëls, Marian, Karst, Henk, DeRijk, Roel, de Kloet, E. Ronald·2008·Trends in Neurosciences

Abstract

Corticosteroids - secreted after stress - have profound effects on brain and behavior. These effects are mediated by mineralocorticoid and glucocorticoid receptors, which are abundantly expressed in limbic neurons. The role of mineralocorticoid receptors in higher brain functions has never been well understood. Here we argue that the recently discovered low-affinity membrane version of the mineralocorticoid receptor contributes to the initial phase of the stress reaction; this is complemented by the glucocorticoid receptor which terminates the stress response. This concept may explain why human carriers of a mineralocorticoid receptor gene variant display enhanced neuroendocrine and autonomic responsiveness to a psychological stressor.

Integrity signals

Registry

Crossref · 10.1016/j.tins.2007.10.005

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  • Glucocorticoid receptors are ubiquitously expressed in the brain but most abundant in the PVN and hippocampus; mineralocorticoid receptor expression is mostly confined to limbic sites regulating salt appetite and autonomic outflow.

    “Although GRs are ubiquitously expressed in the brain, they are most abundant in the PVN and the hippocampus. In contrast, MR expression appears mostly confined to a few limbic sites regulating salt appetite and autonomic outflow (70, 71).”

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Authors
Joëls, M., Karst, H., DeRijk, R., & de Kloet, E. R.
Affiliations
  • University of Amsterdam (NL)
  • Leiden University (NL)
Corresponding author
Joëls, Marian
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2008-01
Volume
31
Issue
1
Pages
1-7
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2148731425
Cited by
481
References
55
Citations by year
2026: 3 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 24 · 2020: 16 · 2019: 29 · 2018: 26 · 2017: 32 · 2016: 47 · 2015: 30 · 2014: 41 · 2013: 36 · 2012: 32
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Koninklijke Nederlandse Akademie van Wetenschappen
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
mineralocorticoid receptor, glucocorticoid receptor, corticosteroids, stress response, limbic system, genetic variants, psychological stress
MeSH terms
Animals, Brain Chemistry, Humans, Stress, Psychological, Receptors, Mineralocorticoid

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