The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
How it’s Made: Organisational Effects of Hormones on the Developing Brain
Open accessAbstract
Gonadal steroid hormones exert permanent organisational effects on the developing brain and thereby direct adult hormonal responsiveness to dictate sex‐specific behaviour and physiology. Considerable progress has been made in elucidating the cellular mechanism of action of androgens and oestrogens during the perinatal sensitive period during which organisation occurs. This review highlights the findings obtained with respect to differential cell death and synaptogenesis with an emphasis on region‐specific mechanisms that involve diverse signalling molecules including tumour necrosis factor‐α, BAX, GABA, glutamate, prostaglandin E 2, FAK and paxillin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“For females, this time represents a “sensitive period” during which masculinization can be induced as a result of exposure to high levels of steroids, either naturally or experimentally (McCarthy, 2010).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as McCarthy, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MAEDA, K., OHKURA, S., & Tsukamura, H. (2000) · Elsevier eBooks · doi:10.1016/b978-012426400-7/50048-0 · Cited by 2,136
PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934
(2009) · Elsevier eBooks · doi:10.1016/c2009-1-03789-7 · Cited by 1,543
Sexual differentiation of the vertebrate nervous system
Morris, J. A., Jordan, C. L., & Breedlove, S. M. (2004) · Nature Neuroscience · doi:10.1038/nn1325 · Cited by 627
A review of brain aromatase cytochrome P450
LEPHART, E. (1996) · Brain Research Reviews · doi:10.1016/0165-0173(96)00002-1 · Cited by 505
EP2 and EP4 prostanoid receptor signaling
Regan, J. W. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.09.031 · Cited by 424
Prostanoids and prostanoid receptors in signal transduction
Bos, C. L., Richel, D. J., Ritsema, T., Peppelenbosch, M. P., & Versteeg, H. H. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.08.006 · Cited by 396
Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior
Amateau, S. K., & McCarthy, M. M. (2004) · Nature Neuroscience · doi:10.1038/nn1254 · Cited by 340
Self-citationDavis, E. C., Popper, P., & Gorski, R. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00298-3 · Cited by 330
Hormonal influences on sexually differentiated behavior in nonhuman primates.
Wallen, K. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.02.001 · Cited by 305
Chandrasekharan, N., & Simmons, D. L. (2004) · Genome biology · doi:10.1186/gb-2004-5-9-241 · Cited by 292
When is a sex difference not a sex difference?
McCarthy, M. M., & Konkle, A. T. M. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.06.001 · Cited by 265
Self-citationMong, J. A., Glaser, E. M., & McCarthy, M. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01464.1999 · Cited by 229
Self-citationA Novel Mechanism of Dendritic Spine Plasticity Involving Estradiol Induction of Prostaglandin-E2
Amateau, S. K., & McCarthy, M. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08586.2002 · Cited by 211
Self-citationPyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins
Ivanković-Dikić, I., Gronroos, E. C., Blaukat, A., Barth, B. U., & Đikić, I. (2000) · Nature Cell Biology · doi:10.1038/35023515 · Cited by 204
Role for estradiol in female-typical brain and behavioral sexual differentiation
Bakker, J., & Baum, M. J. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.06.001 · Cited by 196
FAK and PYK2/CAKβ in the nervous system: a link between neuronal activity, plasticity and survival?
Girault, J., Costa, A., Derkinderen, P., Studler, J., & Toutant, M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01358-7 · Cited by 196
Effects of estrogen in the CNS
Woolley, C. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80051-8 · Cited by 192
Sexual Differentiation of the Human Nervous System
Breedlove, S. M. (1994) · Annual Review of Psychology · doi:10.1146/annurev.ps.45.020194.002133 · Cited by 181
Döhler, K.-D., Hancke, J. L., Srivastava, S. S., Hofmann, C., Shryne, J. E., & Gorski, R. A. (1984) · Progress in brain research · doi:10.1016/s0079-6123(08)64430-1 · Cited by 166
Of Mice and Women: The Bias in Animal Models
Wald, C., & Wu, C. (2010) · Science · doi:10.1126/science.327.5973.1571 · Cited by 160
Schwarz, J. M., Liang, S.-L., Thompson, S. M., & McCarthy, M. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.008 · Cited by 139
Self-citationSnyder, E. M., Colledge, M., Crozier, R. A., Chen, W. S., Scott, J. D., & Bear, M. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409693200 · Cited by 119
Estrogen Induces Caspase-Dependent Cell Death during Hypothalamic Development
Waters, E. M., & Simerly, R. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0135-09.2009 · Cited by 107
DonCarlos, L. L., & Handa, R. J. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90133-3 · Cited by 102
Wright, C. L., & McCarthy, M. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3603-09.2009 · Cited by 92
Self-citationSexual Differentiation of the Brain: Mode, Mechanisms, and Meaning
McCarthy, M. M., Vries, G. J. D., & Forger, N. G. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00054-1 · Cited by 85
Self-citationShors, T. J., & Miesegaes, G. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202199999 · Cited by 78
Two Perspectives on the Origin of Sex Differences in the Brain
Arnold, A. P., Rissman, E. F., & Vries, G. J. D. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.018 · Cited by 74
Wright, C. L., Burks, S. R., & McCarthy, M. M. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20665 · Cited by 69
Self-citationProstaglandin-E2: A point of divergence in estradiol-mediated sexual differentiation
Todd, B. J., SCHWARZ, J., & McCarthy, M. J. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.011 · Cited by 64
Self-citationSexual Differentiation of Human Brain and Behavior
Hines, M. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50072-x · Cited by 63
Central role of TRAF-interacting protein in a new model of brain sexual differentiation
Krishnan, S., Intlekofer, K. A., Aggison, L. K., & Petersen, S. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906293106 · Cited by 61
Tsukahara, S., Kakeyama, M., & Toyofuku, Y. (2006) · Journal of Neurobiology · doi:10.1002/neu.20276 · Cited by 54
Tsukahara, S., Hojo, R., Kuroda, Y., & Fujimaki, H. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.006 · Cited by 45
SCHWARZ, J., & McCarthy, M. J. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.07.004 · Cited by 43
Self-citationSearles, R. V., Yoo, M.-J., He, J., Shen, W., & SELMANOFF, M. K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02648-2 · Cited by 42
Focal Adhesion Kinase and Paxillin: Novel Regulators of Brain Sexual Differentiation?
Speert, D. B., Konkle, A. T. M., Zup, S. L., Schwarz, J. M., Shiroor, C., Taylor, M. E., & McCarthy, M. M. (2007) · Endocrinology · doi:10.1210/en.2006-0845 · Cited by 38
Self-citationSex differences in the effects of amiloride on formalin test nociception in mice
Chanda, M. L., & Mogil, J. S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00902.2005 · Cited by 33
Cited by
Sorted by citations
Sex differences in autism spectrum disorder: a review
Ferri, S. L., Abel, T., & Brodkin, E. S. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0874-2 · Cited by 392
Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology
Gravholt, C. H., Chang, S., Wallentin, M., Fedder, J., Moore, P. J., & Skakkebaek, A. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00212 · Cited by 354
Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes
Holder, M. K., & Blaustein, J. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.10.004 · Cited by 279
Carroll, J. C., Rosario, E. R., Kreimer, S., Villamagna, A., Gentzschein, E., Stanczyk, F. Z., & Pike, C. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.009 · Cited by 273
Kopec, A. M., Smith, C. J. W., Ayre, N. R., Sweat, S. C., & Bilbo, S. D. (2018) · Nature Communications · doi:10.1038/s41467-018-06118-z · Cited by 272
Metadata
- Authors
- McCarthy, M. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- McCarthy, M. M.
- ORCID
- McCarthy, M. M.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2010-06-15
- Volume
- 22
- Issue
- 7
- Pages
- 736-742
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- PMC
- PMC3170038
- OpenAlex
- W1534702329
- Cited by
- 138
- References
- 39
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 17 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 18 · 2012: 5
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH052716)
- National Institute of Neurological Disorders and Stroke (R01NS050525)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- sex steroids, brain development, androgens, estrogen, sex differences, cell death, synaptogenesis, TNF-α, Bax, GABA, glutamate, prostaglandin E2, focal adhesion kinase, paxillin, signaling molecules
- MeSH terms
- Animals, Brain, Cell Survival, Estradiol, Humans, Hypothalamus, Preoptic Area, Sex Characteristics, Gonadal Steroid Hormones, Synapses, Signal Transduction, Cell Death, Glutamic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
