Cited by 138Sexual Differentiation and DisordersNeuroendocrine regulation and behaviorEstrogen and related hormone effects

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How it’s Made: Organisational Effects of Hormones on the Developing Brain

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McCarthy, M. M.·2010·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2010.02021.xPMC PMC3170038

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Abstract

Gonadal steroid hormones exert permanent organisational effects on the developing brain and thereby direct adult hormonal responsiveness to dictate sex‐specific behaviour and physiology. Considerable progress has been made in elucidating the cellular mechanism of action of androgens and oestrogens during the perinatal sensitive period during which organisation occurs. This review highlights the findings obtained with respect to differential cell death and synaptogenesis with an emphasis on region‐specific mechanisms that involve diverse signalling molecules including tumour necrosis factor‐α, BAX, GABA, glutamate, prostaglandin E 2, FAK and paxillin.

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Authors: McCarthy, M. M.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: McCarthy, M. M.
ORCID: McCarthy, M. M.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2010-06-15
Volume: 22
Issue: 7
Pages: 736-742
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2010.02021.x
PMC: PMC3170038
OpenAlex: W1534702329
Cited by: 138
References: 39
Citations by year: 2026: 7 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 17 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 18 · 2012: 5
FWCI: 0.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH052716)
National Institute of Neurological Disorders and Stroke (R01NS050525)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: sex steroids, brain development, androgens, estrogen, sex differences, cell death, synaptogenesis, TNF-α, Bax, GABA, glutamate, prostaglandin E2, focal adhesion kinase, paxillin, signaling molecules
MeSH terms: Animals, Brain, Cell Survival, Estradiol, Humans, Hypothalamus, Preoptic Area, Sex Characteristics, Gonadal Steroid Hormones, Synapses, Signal Transduction, Cell Death, Glutamic Acid

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How it’s Made: Organisational Effects of Hormones on the Developing Brain

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