The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
How it’s Made: Organisational Effects of Hormones on the Developing Brain
Open accessAbstract
Gonadal steroid hormones exert permanent organisational effects on the developing brain and thereby direct adult hormonal responsiveness to dictate sex‐specific behaviour and physiology. Considerable progress has been made in elucidating the cellular mechanism of action of androgens and oestrogens during the perinatal sensitive period during which organisation occurs. This review highlights the findings obtained with respect to differential cell death and synaptogenesis with an emphasis on region‐specific mechanisms that involve diverse signalling molecules including tumour necrosis factor‐α, BAX, GABA, glutamate, prostaglandin E 2, FAK and paxillin.
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“For females, this time represents a “sensitive period” during which masculinization can be induced as a result of exposure to high levels of steroids, either naturally or experimentally (McCarthy, 2010).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as McCarthy, 2010
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(2009) · Elsevier eBooks · doi:10.1016/c2009-1-03789-7 · Cited by 1,543
Sexual differentiation of the vertebrate nervous system
Morris, J. A., Jordan, C. L., & Breedlove, S. M. (2004) · Nature Neuroscience · doi:10.1038/nn1325 · Cited by 627
A review of brain aromatase cytochrome P450
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EP2 and EP4 prostanoid receptor signaling
Regan, J. W. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.09.031 · Cited by 424
Prostanoids and prostanoid receptors in signal transduction
Bos, C. L., Richel, D. J., Ritsema, T., Peppelenbosch, M. P., & Versteeg, H. H. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.08.006 · Cited by 396
Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior
Amateau, S. K., & McCarthy, M. M. (2004) · Nature Neuroscience · doi:10.1038/nn1254 · Cited by 340
Self-citationDavis, E. C., Popper, P., & Gorski, R. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00298-3 · Cited by 330
Hormonal influences on sexually differentiated behavior in nonhuman primates.
Wallen, K. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.02.001 · Cited by 305
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Metadata
- Authors
- McCarthy, M. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- McCarthy, M. M.
- ORCID
- McCarthy, M. M.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2010-06-15
- Volume
- 22
- Issue
- 7
- Pages
- 736-742
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- PMC
- PMC3170038
- OpenAlex
- W1534702329
- Cited by
- 138
- References
- 39
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 17 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 18 · 2012: 5
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH052716)
- National Institute of Neurological Disorders and Stroke (R01NS050525)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- sex steroids, brain development, androgens, estrogen, sex differences, cell death, synaptogenesis, TNF-α, Bax, GABA, glutamate, prostaglandin E2, focal adhesion kinase, paxillin, signaling molecules
- MeSH terms
- Animals, Brain, Cell Survival, Estradiol, Humans, Hypothalamus, Preoptic Area, Sex Characteristics, Gonadal Steroid Hormones, Synapses, Signal Transduction, Cell Death, Glutamic Acid
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