Cited by 189Bacterial Genetics and BiotechnologySalmonella and Campylobacter epidemiologyEscherichia coli research studies

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Biosynthesis and IroC‐dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium

Crouch, Marie‐Laure V., Castor, Margaret, Karlinsey, Joyce E., Kalhorn, Thomas, Fang, Ferric C.·2008·Molecular Microbiology

DOI 10.1111/j.1365-2958.2007.06089.x

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Abstract

In response to iron deprivation, Salmonella enterica serovar Typhimurium secretes two catecholate-type siderophores, enterobactin and its glucosylated derivative salmochelin. Although the systems responsible for enterobactin synthesis and acquisition are well characterized, the mechanisms of salmochelin secretion and acquisition, as well as its role in Salmonella virulence, are incompletely understood. Herein we show by liquid chromatography-mass spectrometry analysis of culture supernatants from wild type and isogenic mutant bacterial strains that the Major Facilitator Superfamily pump EntS is the major exporter of enterobactin and the ABC transporter IroC exports both salmochelin and enterobactin. Growth promotion experiments demonstrate that IroC is not required for utilization of Fe-enterobactin or Fe-salmochelin, as had been previously suggested, but the ABC transporter protein FepD is required for utilization of both siderophores. Salmonella mutants deficient in salmochelin synthesis or secretion exhibit reduced virulence during systemic infection of mice.

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Authors: Crouch, M. V., Castor, M., Karlinsey, J. E., Kalhorn, T., & Fang, F. C.
Affiliations: University of Washington (US)
Corresponding author: Fang, Ferric C.
ORCID: Karlinsey, Joyce E.
Fang, Ferric C.
Venue: Molecular Microbiology
Publisher: Wiley
Published: 2008-01-14
Volume: 67
Issue: 5
Pages: 971-983
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1111/j.1365-2958.2007.06089.x
OpenAlex: W2087509245
Cited by: 187
References: 46
Citations by year: 2026: 8 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 13 · 2021: 10 · 2020: 14 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 14 · 2015: 12 · 2014: 14 · 2013: 12 · 2012: 11
FWCI: 6.33
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI54052, AI 39557, R01AI050660, AI50660, F32AI054052)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: salmochelin, enterobactin, siderophore biosynthesis, iron acquisition, iron starvation, Salmonella typhimurium, bacterial virulence, catecholate siderophores, systemic infection
MeSH terms: Animals, Bacterial Proteins, Biological Transport, Chromatography, Liquid, Enterobactin, Iron, Membrane Proteins, Salmonella Infections, Animal, Salmonella typhimurium, Mass Spectrometry, Virulence, Siderophores, Sequence Deletion, ATP-Binding Cassette Transporters, Mice

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Biosynthesis and IroC‐dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium

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