Diverse effects of gut-derived serotonin in intestinal inflammation
Abstract
The gut is the largest producer of serotonin or 5-hydroxytryptamine (5-HT) in the human body, and 5-HT has been recognized as an important signaling molecule in the gut for decades. There are two distinct sources of enteric 5-HT. Mucosal 5-HT is predominantly produced by enterochromaffin (EC) cells of the gastrointestinal (GI) tract, and neuronal 5-HT in the gut is produced by serotonergic neurons of the enteric nervous system (ENS). The quantity of mucosal 5-HT produced vastly eclipses the amount of neuronal 5-HT in the gut. Though it is difficult to separate the functions of neuronal and mucosal 5-HT, in the normal gut both types of enteric 5-HT work synergistically playing a prominent role in the maintenance of GI functions. In inflammatory conditions of the gut, like inflammatory bowel disease (IBD) recent studies have revealed new diverse functions of enteric 5-HT. Mucosal 5-HT plays an important role in the production of pro-inflammatory mediators from immune cells, and neuronal 5-HT provides neuroprotection in the ENS. Based on searches for terms such as "5-HT", "EC cell", "ENS", and "inflammation" in pubmed.gov as well as by utilizing pertinent reviews, the current review aims to provide an update on the role of enteric 5-HT and its immune mediators in the context of intestinal inflammation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A direct effect of intestinally produced 5-HT on the brain is unlikely because it cannot penetrate the blood-brain barrier; stimulation of vagal afferents and regulation of immune responses could be potential signaling pathways.
“While a direct effect of intestinally produced 5-HT on the brain is unlikely as it cannot penetrate the BBB, stimulation of vagal afferents and regulation of the immune responses could be potential signaling pathways (388, 389).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [389]
Cites
Revised Estimates for the Number of Human and Bacteria Cells in the Body
Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425 · see citing works
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · see citing works
Chemically induced mouse models of intestinal inflammation
Wirtz, S., Neufert, C., Weigmann, B., & Neurath, M. F. (2007) · Nature Protocols · doi:10.1038/nprot.2007.41 · Cited by 1,567 · see citing works
Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563 · see citing works
Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
Russo, E. B. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01238.x · Cited by 1,535 · see citing works
Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335 · see citing works
Serotonin signalling in the gut: functions, dysfunctions and therapeutic targets
Mawe, G. M., & Hoffman, J. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.105 · Cited by 1,165 · see citing works
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155 · see citing works
Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases
Strober, W., & Fuss, I. J. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.016 · Cited by 1,105 · see citing works
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 962 · see citing works
Heyes, M. P., Saito, K., Crowley, J. S., DAVIS, L. E., Demitrack, M. A., Der, M. G., Dilling, L. A., Elia, J., Kruesi, M. J. P., Lackner, A. A., et al. (1992) · Brain · doi:10.1093/brain/115.5.1249 · Cited by 682 · see citing works
5-HT3 receptors are membrane ion channels
Derkach, V. A., Surprenant, A., & NORTH, R. A. (1989) · Nature · doi:10.1038/339706a0 · Cited by 630 · see citing works
Dunlop, S. P., Jenkins, D., Neal, K. R., & Spiller, R. C. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.028 · Cited by 583 · see citing works
Zhu, C.-B., Blakely, R. D., & Hewlett, W. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301029 · Cited by 549 · see citing works
Törnblom, H., Lindberg, G., Nyberg, B., & Veress, B. (2002) · Gastroenterology · doi:10.1053/gast.2002.37059 · Cited by 516 · see citing works
Collins, S. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70034-3 · Cited by 511 · see citing works
Neurochemical classification of myenteric neurons in the guinea-pig ileum
Costa, M., Brookes, S. J., Steeled, P. A., Gibbins, I. L., Burcher, E., & Kandiah, C. J. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00275-8 · Cited by 480 · see citing works
Serotonin: A Mediator of The Brain–Gut Connection
Kim, D.-Y., & Camilleri, M. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03177.x · Cited by 448 · see citing works
Serotonin has a key role in pathogenesis of experimental colitis.
Ghia, J., Li, N., Wang, H.-Q., Collins, M., Deng, Y.-K., El-Sharkawy, R. T., Côté, F., Mallet, J., & Khan, W. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.041 · Cited by 417 · see citing works
Self-citationLi, Z., Chalazonitis, A., Huang, Y.-Y., Mann, J. J., Margolis, K. G., Yang, Q. M., Kim, D. O., Cote, F., Mallet, J., & Gershon, M. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6684-10.2011 · Cited by 403 · see citing works
Chen, J. C., Li, Z., Pan, H., Murphy, D. L., Tamir, H., Koepsell, H., & Gershon, M. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06348.2001 · Cited by 397 · see citing works
The role of serotonin and its receptors in activation of immune responses and inflammation
Shajib, M. S., & Khan, W. I. (2014) · Acta Physiologica · doi:10.1111/apha.12430 · Cited by 373 · see citing works
Self-citation5-HT4Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice
Liu, M., Kuan, Y., Wang, J., Hen, R., & Gershon, M. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1145-09.2009 · Cited by 350 · see citing works
Leon‐Ponte, M., Ahern, G. P., & O’Connell, P. J. (2006) · Blood · doi:10.1182/blood-2006-10-052787 · Cited by 349 · see citing works
Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
Duerschmied, D., Suidan, G. L., Demers, M., et al. (2012) · Blood · doi:10.1182/blood-2012-06-437392 · Cited by 347 · see citing works
Epithelial restitution and wound healing in inflammatory bowel disease
Sturm, A., & Dignass, A. U. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.348 · Cited by 334 · see citing works
Classification and functions of enteroendocrine cells of the lower gastrointestinal tract
Gunawardene, A. R., Corfe, B. M., & Staton, C. A. (2011) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2011.00767.x · Cited by 311 · see citing works
A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin
Baganz, N. L., & Blakely, R. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300186b · Cited by 308 · see citing works
Inflammatory neuropathies of the enteric nervous system☆
GIORGIO, R. D., Guerrini, S., Barbara, G., Stanghellini, V., Ponti, F. D., Corinaldesi, R., Moses, P. L., Sharkey, K. A., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.024 · Cited by 303 · see citing works
Allergy and the gastrointestinal system
Vighi, G., Marcucci, F., Sensi, L., Di Cara, G., & Frati, F. (2008) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2008.03713.x · Cited by 291 · see citing works
Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis
Linden, D. R., Chen, J.-X., Gershon, M. D., Sharkey, K. A., & Mawe, G. M. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00488.2002 · Cited by 291 · see citing works
Idzko, M., Panther, E., Stratz, C., Müller, T., Bayer, H., Zissel, G., Dürk, T., Sorichter, S., Virgilio, F. D., Geißler, M., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6011 · Cited by 272 · see citing works
Structural abnormalities of the nervous system in Crohn's disease and ulcerative colitis
Geboes, K., & Collins, S. (1998) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1998.00102.x · Cited by 255 · see citing works
Furness, J. B., & Costa, M. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90271-8 · Cited by 255 · see citing works
Keohane, J., O’Mahony, C., O’Mahony, L., O’Mahony, S. M., Quigley, E. M. M., & Shanahan, F. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.156 · Cited by 254 · see citing works
Gut chemosensing: Interactions between gut endocrine cells and visceral afferents
Raybould, H. E. (2010) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.07.007 · Cited by 254 · see citing works
Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7
Casas-Engel, M. D. L., Domínguez‐Soto, Á., Sierra‐Filardi, E., Bragado, R., Nieto, C., Puig‐Kröger, A., Samaniego, R., Loza, M. I., Corcuera, M. T., Gómez, F., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201133 · Cited by 253 · see citing works
Hasnain, S. Z., Tauro, S., Das, I., Tong, H., Chen, A. C. –., Jeffery, P. L., McDonald, V., Florin, T. H., & McGuckin, M. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.043 · Cited by 251 · see citing works
Minderhoud, I. M., Oldenburg, B., Wismeijer, J. A., Henegouwen, G. P. V. B., & Smout, A. J. P. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020506.84248.f9 · Cited by 243 · see citing works
Brezun, J. M., & Daszuta, A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00932.x · Cited by 243 · see citing works
Treatment of IBD: Where We Are and Where We Are Going
Bernstein, C. N. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.357 · Cited by 236 · see citing works
Human enteric neuropathies: morphology and molecular pathology
GIORGIO, R. D., & Camilleri, M. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00538.x · Cited by 221 · see citing works
Neuroinflammation in inflammatory bowel disease
Lakhan, S. E., & Kirchgessner, A. L. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-37 · Cited by 216 · see citing works
Dürk, T., Panther, E., Müller, T., Sorichter, S., Ferrari, D., Pizzirani, C., Virgilio, F. D., Myrtek, D., Norgauer, J., & Idzko, M. (2005) · International Immunology · doi:10.1093/intimm/dxh242 · Cited by 213 · see citing works
The immune system in irritable bowel syndrome
Barbara, G., Cremon, C., Carini, G., Bellacosa, L., Zecchi, L., Giorgio, R. D., Corinaldesi, R., & Stanghellini, V. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.349 · Cited by 211 · see citing works
Andresen, V., Montori, V. M., Keller, J., West, C. P., Layer, P., & Camilleri, M. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.12.015 · Cited by 207 · see citing works
Bischoff, S. C., Mailer, R., Pabst, O., Weier, G., Sedlik, W., Li, Z., Chen, J. J., Murphy, D. L., & Gershon, M. D. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90685.2008 · Cited by 206 · see citing works
Wheatcroft, J., Wakelin, D., Smith, A., Mahoney, C. R., Mawe, G., & Spiller, R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00719.x · Cited by 205 · see citing works
Review article: intestinal serotonin signalling in irritable bowel syndrome
Mawe, G. M., Coates, M. D., & Moses, P. L. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02858.x · Cited by 205 · see citing works
Damage to the Enteric Nervous System in Experimental Colitis
Sanovic, S., Lamb, D. P., & Blennerhassett, M. G. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65207-8 · Cited by 203 · see citing works
Serotonin 5-HT2A Receptor Activation Blocks TNF-α Mediated Inflammation In Vivo
Nau, F., Yu, B.-N., Martin, D. A., & Nichols, C. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075426 · Cited by 197 · see citing works
Post-infectious irritable bowel syndrome
Thabane, M. E., & Marshall, J. K. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.3591 · Cited by 194 · see citing works
Margolis, K. G., Stevanovic, K. D., Li, Z., Yang, Q., Oravecz, T., Zambrowicz, B., Jhaver, K. G., Diacou, A., & Gershon, M. D. (2013) · Gut · doi:10.1136/gutjnl-2013-304901 · Cited by 192 · see citing works
Indiscriminate loss of myenteric neurones in the TNBS‐inflamed guinea‐pig distal colon
Linden, D. R., Couvrette, J. M., Ciolino, A. L., Mcquoid, C., Blaszyk, H., Sharkey, K. A., & Mawe, G. M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00703.x · Cited by 186 · see citing works
Serotonin and GI Disorders: An Update on Clinical and Experimental Studies
Manocha, M. M., & Khan, W. I. (2012) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2012.8 · Cited by 185 · see citing works
Self-citationGut hormones: emerging role in immune activation and inflammation
Khan, W. I., & Ghia, J. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04150.x · Cited by 184 · see citing works
Self-citationMouse Taste Buds Use Serotonin as a Neurotransmitter
Huang, Y.-J., Maruyama, Y., Lu, K., Pereira, E., Plonsky, I., Baur, J. E., Wu, D., & Roper, S. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4446-04.2005 · Cited by 183 · see citing works
The Enteric Nervous System I: Organisation and Classification
Hansen, M. B. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.t01-1-920301.x · Cited by 182 · see citing works
Enteric nervous system abnormalities in inflammatory bowel diseases
Villanacci, V., Bassotti, G., Nascimbeni, R., Antonelli, E., Cadei, M., Fisogni, S., Salerni, B., & Geboes, K. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01146.x · Cited by 177 · see citing works
Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients
Huengsberg, M., Winer, J. B., Gompels, M., Round, R., Ross, J., & Shahmanesh, M. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.4.858 · Cited by 172 · see citing works
Müller, T., Dürk, T., Blumenthal, B., Grimm, M., Cicko, S., Panther, E., Sorichter, S., Herouy, Y., Virgilio, F. D., Ferrari, D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006453 · Cited by 171 · see citing works
Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice
Gross, E. R., Gershon, M. D., Margolis, K. G., Gertsberg, Z. V., & Cowles, R. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.007 · Cited by 167 · see citing works
Pharmacology of serotonin: what a clinician should know
Ponti, F. D. (2004) · Gut · doi:10.1136/gut.2003.035568 · Cited by 158 · see citing works
Enteric Nervous System in the Small Intestine: Pathophysiology and Clinical Implications
Nezami, B. G., & Srinivasan, S. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0129-9 · Cited by 155 · see citing works
L-Tryptophan: Biochemical, nutritional and pharmacological aspects
Sainio, E., Pulkki, K., & Young, S. (1996) · Amino Acids · doi:10.1007/bf00806091 · Cited by 155 · see citing works
Serotonin and the 5-HT2BReceptor in the Development of Enteric Neurons
Fiorica‐Howells, E., Maroteaux, L., & Gershon, M. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00294.2000 · Cited by 151 · see citing works
5-Hydroxytryptamine Induces Mast Cell Adhesion and Migration
Kushnir‐Sukhov, N. M., Gilfillan, A. M., Coleman, J. W., Brown, J. M., Bruening, S., Tóth, M., & Metcalfe, D. D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6422 · Cited by 151 · see citing works
Serotonin Upregulates Mitogen-Stimulated B Lymphocyte Proliferation through 5-HT1AReceptors
Iken, K., Chheng, S., Fargin, A., Goulet, A.-C., & Kouassi, É. (1995) · Cellular Immunology · doi:10.1006/cimm.1995.1092 · Cited by 149 · see citing works
Serum Analysis of Tryptophan Catabolism Pathway: Correlation with Crohn’s Disease Activity
Gupta, N., Thaker, A., Kanuri, N. D., Riehl, T., Rowley, C., Stenson, W., & Ciorba, M. A. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21849 · Cited by 144 · see citing works
The role of serotonin in intestinal luminal sensing and secretion
Hansen, M. B., & Witte, A. ‐. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01870.x · Cited by 144 · see citing works
Foley, S., Garsed, K. C., Singh, G., Duroudier, N. P., Swan, C., Hall, I. P., Zaitoun, A. M., Bennett, A. J., Marsden, C. A., Holmes, G. K. T., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.052 · Cited by 141 · see citing works
Khan, W., Motomura, Y., Wang, H., et al. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00069.2006 · Cited by 141 · see citing works
Self-citationKim, J., Bridle, B. W., Ghia, J., Wang, H., Syed, S. N., Manocha, M. M., Palanivel, R., Shajib, M. S., Wan, Y., Hedlund, P. B., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201887 · Cited by 139 · see citing works
Self-citationSerotonin Activates Dendritic Cell Function in the Context of Gut Inflammation
Li, N., Ghia, J., Wang, H., McClemens, J., Côté, F., Suehiro, Y., Mallet, J. J., & Khan, W. I. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.10.028 · Cited by 137 · see citing works
Self-citationSerotonin transporter function and expression are reduced in mice with TNBS‐induced colitis
Linden, D. R., Foley, K. F., Mcquoid, C., Simpson, J., Sharkey, K. A., & Mawe, G. M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00673.x · Cited by 134 · see citing works
Myenteric plexus injury and apoptosis in experimental colitis
Boyer, L., Ghoreishi, M., Templeman, V., Vallance, B. A., Buchan, A. M. J., Jevon, G. P., & Jacobson, K. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.10.006 · Cited by 131 · see citing works
IL1β‐ and LPS‐induced serotonin secretion is increased in EC cells derived from Crohn’s disease
Kidd, M., Gustafsson, B. I., Drozdov, I., & Modlin, I. M. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01210.x · Cited by 130 · see citing works
THE MECHANISM OF SEROTONIN AND CATECHOLAMINE UPTAKE BY PLATELETS
Hughes, F. B., & Brodie, B. B. (1959) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)25664-6 · Cited by 129 · see citing works
Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon
Spohn, S. N., Bianco, F., Scott, R. B., Keenan, C. M., Linton, A. A., O'Neill, C. H., Bonora, E., Dicay, M. S., Lavoie, B. A., Wilcox, R. L., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.032 · Cited by 126 · see citing works
Wang, H., Steeds, J., Motomura, Y., Deng, Y., Verma–Gandhu, M., El–Sharkawy, R. T., McLaughlin, J. T., Grencis, R. K., & Khan, W. I. (2007) · Gut · doi:10.1136/gut.2006.103226 · Cited by 122 · see citing works
Self-citationAbsorption of serotonin (5‐hydroxytryptamine) and histamine by dog platelets
Humphrey, J., & Toh, C. C. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005108 · Cited by 117 · see citing works
Gut endocrine cell development
May, C. L., & Kaestner, K. H. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.009 · Cited by 115 · see citing works
Boehme, S. A., Lio, F. M., Sikora, L., Pandit, T. S., Lavrador, K., Sriramarao, P., & Sriramarao, P. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3599 · Cited by 115 · see citing works
Enteric Neuronal Density Contributes to the Severity of Intestinal Inflammation
Margolis, K. G., Stevanovic, K. D., Karamooz, N., Li, Z. S., Ahuja, A., D’Autréaux, F., Saurman, V. E., Chalazonitis, A., & Gershon, M. D. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.047 · Cited by 113 · see citing works
Kong, E., Sučić, S., Monje, F. J., Reisinger, S. N., Savalli, G., Diao, W., Khan, D., Ronovsky, M., Cabatic, M., Koban, F., et al. (2015) · Scientific Reports · doi:10.1038/srep09009 · Cited by 111 · see citing works
Colitis Induces Enteric Neurogenesis Through a 5-HT4–dependent Mechanism
Belkind‐Gerson, J., Hotta, R., Nagy, N., Thomas, A. R., Graham, H. K., Cheng, L. S., Adame, J. J. S., Nguyen, D. D., Kamionek, M., Dietrich, J., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000326 · Cited by 103 · see citing works
Photophysics of a neurotransmitter: ionization and spectroscopic properties of serotonin
Chattopadhyay, A., Rukmini, R., & Mukherjee, S. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79393-1 · Cited by 99 · see citing works
Dizdar, V., Spiller, R. E., SINGH, G., Hanevik, K., Gilja, O. H., El‐Salhy, M., & Hausken, T. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04251.x · Cited by 95 · see citing works
Palmer, J. M., Wong‐Riley, M. T. T., & Sharkey, K. A. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.5.g922 · Cited by 95 · see citing works
IFN-γ and TNF-α decrease serotonin transporter function and expression in Caco2 cells
Foley, K. F., Pantano, C., Ciolino, A. L., & Mawe, G. M. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00470.2006 · Cited by 94 · see citing works
McDermott, J. R., Humphreys, N. E., Forman, S. P., Donaldson, D. D., & Grencis, R. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3207 · Cited by 93 · see citing works
Regmi, S. C., Park, S., Ku, S., & Kim, J. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.003 · Cited by 93 · see citing works
Serotonin upregulates the activity of phagocytosis through 5‐HT1A receptors
Freire‐Garabal, M., Núñez, M. J., Balboa, J. L., et al. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705188 · Cited by 93 · see citing works
Gill, R. K., Pant, N., Saksena, S., et al. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00354.2007 · Cited by 91 · see citing works
Nutrient‐induced changes in the phenotype and function of the enteric nervous system
Neunlist, M., & Schemann, M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.272948 · Cited by 90 · see citing works
Keating, C. D., Beyak, M. J., Foley, S., Singh, G., Marsden, C. A., Spiller, R. E., & Grundy, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156984 · Cited by 88 · see citing works
Khan, W. I., Vallance, B. A., Blennerhassett, P. A., Deng, Y., Verdu, E. F., MATTHAEI, K. I., & Collins, S. M. (2001) · Infection and Immunity · doi:10.1128/iai.69.2.838-844.2001 · Cited by 84 · see citing works
Self-citationO’Hara, J. R., Skinn, A. C., MacNaughton, W. K., Sherman, P. M., & Sharkey, K. A. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00657.x · Cited by 82 · see citing works
Haub, S., Ritze, Y., Bergheim, I., Pabst, O., Gershon, M. D., & Bischoff, S. C. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01479.x · Cited by 80 · see citing works
Motomura, Y., Ghia, J., Wang, H., Akiho, H., El–Sharkawy, R. T., Collins, M., Wan, Y., McLaughlin, J. T., & Khan, W. I. (2008) · Gut · doi:10.1136/gut.2007.129296 · Cited by 80 · see citing works
Self-citationYoung, H. M., & Furness, J. B. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903560107 · Cited by 78 · see citing works
5-HT1B receptors play a prominent role in the proliferation of T-lymphocytes
Yin, J., Albert, R. H., Tretiakova, A. P., & Jameson, B. A. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.08.004 · Cited by 77 · see citing works
5‐HT receptors on interstitial cells of Cajal, smooth muscle and enteric nerves
Wouters, M., Farrugia, G., & Schemann, M. (2007) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2007.00963.x · Cited by 74 · see citing works
Serotonin Is Involved in Autoimmune Arthritis through Th17 Immunity and Bone Resorption
Chabbi-Achengli, Y., Coman, T., Collet, C., Callebert, J., Corcelli, M., Lin, H., Rignault‐Bricard, R., Dy, M., de Vernejoul, M. C., & Côté, F. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.018 · Cited by 71 · see citing works
Kim, J., Wang, H., Terc, J. D., Zambrowicz, B., Yang, Q., & Khan, W. I. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00299.2014 · Cited by 68 · see citing works
Self-citationChemotherapy- and Cancer-Related Nausea and Vomiting
Warr, D. G. (2008) · Current Oncology · doi:10.3747/co.2008.171 · Cited by 67 · see citing works
Berends, A. C., Luiten, P. G. M., & Nyakas, C. J. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00055.x · Cited by 67 · see citing works
Release of Immunoreactive Serotonin Following Acid Perfusion of the Duodenum
Kellum, J. M., & Jaffe, B. M. (1976) · Annals of Surgery · doi:10.1097/00000658-197611000-00018 · Cited by 66 · see citing works
Serotonin activates murine alveolar macrophages through 5-HT2Creceptors
Mikulski, Z., Zasłona, Z., Cakarova, L., Hartmann, P., Wilhelm, J., Tecott, L. H., Lohmeyer, J., & Kummer, W. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00032.2010 · Cited by 65 · see citing works
Hernández, M. E., Martínez‐Fong, D., Pérez-Tapia, M., Estrada‐García, I., Estrada-Parra, S. A., & Pavón, L. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.11.005 · Cited by 64 · see citing works
Cooke, H. J., Sidhu, M., & Wang, Y. (1997) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(97)00075-1 · Cited by 63 · see citing works
Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon
O’Hara, J. R., Lomax, A. E., Mawe, G. M., & Sharkey, K. A. (2006) · Gut · doi:10.1136/gut.2006.102780 · Cited by 62 · see citing works
Wang, X., Vannucchi, M. G., Nieuwmeyer, F., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62988-4 · Cited by 60 · see citing works
Role of Serotonin 5-HT3 Receptors in Intestinal Inflammation
Kato, S. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00363 · Cited by 60 · see citing works
Shajib, M. S., Wang, H., Kim, J., Sunjic, I., Ghia, J., Denou, E., Collins, M. J., Denburg, J. A., & Khan, W. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072774 · Cited by 58 · see citing works
Self-citation5-hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells
Suzuki, A., Naruse, S., Kitagawa, M., Ishiguro, H., Yoshikawa, T., Ko, S. B. H., Yamamoto, A., Hamada, H., & Hayakawa, T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12312 · Cited by 58 · see citing works
Tharayil, V. S., wouters, M. M., Stanich, J. E., Roeder, J. L., lei, S., Beyder, A., Gomez‐Pinilla, P. J., Gershon, M. D., Maroteaux, L., Gibbons, S. J., et al. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01435.x · Cited by 57 · see citing works
Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome
Keszthelyi, D., Troost, F. J., Jonkers, D. M. A. E., van Eijk, H. M. H., Lindsey, P. J., Dekker, J. P., Buurman, W. A., & Masclee, A. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12842 · Cited by 53 · see citing works
Differentiation Between Crohnʼs Disease and Other Inflammatory Conditions by Electron Microscopy
Dvořàk, A. M., & Silen, W. (1985) · Annals of Surgery · doi:10.1097/00000658-198520110-00008 · Cited by 51 · see citing works
Barbaro, M. R., Sabatino, A. D., Cremon, C., Giuffrida, P., Fiorentino, M., Altimari, A., Bellacosa, L., Stanghellini, V., & Barbara, G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00368.2015 · Cited by 50 · see citing works
Pontell, L. J., Castelucci, P., Bagyánszki, M., Jovic, T., Thacker, M., Nurgali, K., Bron, R., & Furness, J. B. (2009) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-009-0795-x · Cited by 49 · see citing works
5-HT7 receptor signaling: improved therapeutic strategy in gut disorders
Kim, J., & Khan, W. I. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00396 · Cited by 49 · see citing works
Self-citationAxonal degeneration/necrosis: a possible ultrastructural marker for Crohn's disease.
Steinhoff, M. M., Kodner, I. J., & Deschryver-Kecskemeti, K. (1988) · PubMed · Cited by 48 · see citing works
Lactobacillus rhamnosus Ingestion Promotes Innate Host Defense in an Enteric Parasitic Infection
McClemens, J., Kim, J., Wang, H., Mao, Y., Collins, M. J., Kunze, W., Bienenstock, J., Forsythe, P., & Khan, W. I. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00047-13 · Cited by 47 · see citing works
Self-citationSerotonin receptor 5-HT7 regulates morphology and migratory properties of dendritic cells
Holst, K., Guseva, D., Schindler, S., Sixt, M., Braun, A. C., Chopra, H., Pabst, O., & Ponimaskin, E. G. (2015) · Journal of Cell Science · doi:10.1242/jcs.167999 · Cited by 44 · see citing works
Manocha, M. M., Shajib, M. S., Rahman, M. M., Wang, H., Rengasamy, P., Bogunovic, M., Jordana, M., Mayer, L., & Khan, W. I. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.58 · Cited by 42 · see citing works
Self-citationLatorre, E., Mendoza, C., Matheus, N., Castro, M., Grasa, L., Mesonero, J. E., & Alcalde, A. I. (2013) · Cytokine · doi:10.1016/j.cyto.2013.01.012 · Cited by 39 · see citing works
Role of 5-HT in cholera toxin-induced mucin secretion in the rat small intestine
Moore, B. A., Sharkey, K. A., & Mantle, M. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.270.6.g1001 · Cited by 39 · see citing works
IBS-like symptoms in patients with ulcerative colitis
Gracie, D. J., & Ford, A. C. (2015) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s58153 · Cited by 38 · see citing works
Zhu, J., Yang, F., Sang, L.-X., Zhai, J., Zhang, X., Yue, D., Li, S., Li, Y., Lu, C., & Sun, X. (2015) · Mediators of Inflammation · doi:10.1155/2015/913041 · Cited by 37 · see citing works
Distribution of 5-HT3, 5-HT4, and 5-HT7Receptors Along the Human Colon
Yaakob, N. S., Chinkwo, K. A., Chetty, N., et al. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14157 · Cited by 36 · see citing works
Vasefi, M., Kruk, J. S., Heikkila, J. J., & Beazely, M. A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12157 · Cited by 36 · see citing works
Säfsten, B., Sjöblom, M., & Flemström, G. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520600641480 · Cited by 36 · see citing works
Acute Fluoxetine Treatment Induces Slow Rolling of Leukocytes on Endothelium in Mice
Herr, N., Mauler, M., Witsch, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088316 · Cited by 35 · see citing works
Tada, Y., Ishihara, S., Kawashima, K., Fukuba, N., Sonoyama, H., Kusunoki, R., Oka, A., Mishima, Y., Oshima, N., Moriyama, I., et al. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13268 · Cited by 33 · see citing works
Alternative non‐coding exons support serotonin transporter mRNA expression in the brain and gut
Ozsarac, N., Santha, E., & Hoffman, B. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00964.x · Cited by 32 · see citing works
The Absence of Tryptophan Hydroxylase Activity in Blood Platelets
Morrissey, J. J., Walker, M., & Lovenberg, W. M. (1977) · Experimental Biology and Medicine · doi:10.3181/00379727-154-39702 · Cited by 32 · see citing works
Overexpression of GATA-3 in T Cells Accelerates Dextran Sulfate Sodium-Induced Colitis
Okamura, M., Yoh, K., Ojima, M., et al. (2014) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.63.133 · Cited by 30 · see citing works
Sarnelli, G., GIORGIO, R. D., Gentile, F., Calı̀, G., Grandone, I., Rocco, A., Cosenza, V., Cuomo, R., & D’Argenio, G. (2008) · Digestive and Liver Disease · doi:10.1016/j.dld.2008.06.004 · Cited by 30 · see citing works
Tomita, T., Kato, Y., Takimoto, M., Yamasaki, T., Kondo, T., Kono, T., Tozawa, K., Yokoyama, Y., Ikehara, H., Ohda, Y., et al. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15160 · Cited by 30 · see citing works
Akiyoshi, T., Zhang, Q., Inoue, F., Aramaki, O., Hatano, M., Shimazu, M., Kitajima, M., Shirasugi, N., & Niimi, M. (2006) · Transplantation · doi:10.1097/01.tp.0000233870.54297.9a · Cited by 27 · see citing works
Anti-IL-13 in Inflammatory Bowel Disease: From the Bench to the Bedside
Jovani, M., Fiorino, G., & Danese, S. (2013) · Current Drug Targets · doi:10.2174/13894501113149990170 · Cited by 26 · see citing works
Neuromuscular changes in a rat model of colitis
Aulí, M., Nasser, Y., Ho, W., Burgueño, J. F., Keenan, C. M., Romero, C., Sharkey, K. A., & Fernández, E. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.04.005 · Cited by 23 · see citing works
Qin, H., Zang, K.-H., Rao, Z., & Zhang, G. (2015) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.169584 · Cited by 17 · see citing works
Schneider, E., Machavoine, F., Rignault‐Bricard, R., Levasseur, M., Petit-Bertron, A.-F., Gautron, S., Ribeil, J., Launay, J., Mécheri, S., Côté, F., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.043 · Cited by 15 · see citing works
Townsend, D., Casey, M. A., & Brown, D. R. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.07.023 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Heiss, C. N., & Olofsson, L. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12684 · Cited by 304 · see citing works
Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920928984 · Cited by 221 · see citing works
BANANA PEEL FLAKES ALLEVIATE BLOOD GLUCOSE AND STRESS IN A DOSE-DEPENDENT MANNER
MELIALA, A., SUMIWI, Y. A. A., NARWIDINA, P., RINI, S. L. S., & SETYANINGSIH, W. (2020) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2020v12i8.37659 · Cited by 10 · see citing works
- Authors
- Shajib, M. S., Baranov, A., & Khan, W. I.
- Affiliations
- McMaster University (CA)
- Hamilton Regional Laboratory Medicine Program (CA)
- Corresponding author
- Khan, Waliul I.
- ORCID
- Khan, Waliul I.
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-03-27
- Volume
- 8
- Issue
- 5
- Pages
- 920-931
- ISSN
- 1948-7193 (ISSN-L)
- OpenAlex
- W2600368530
- Cited by
- 109
- References
- 149
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 13 · 2023: 13 · 2022: 16 · 2021: 16 · 2020: 14 · 2019: 8 · 2018: 7
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Chemical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Crohn’s and Colitis Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- serotonin, intestinal inflammation, enterochromaffin cells, enteric nervous system, serotonergic neurons, inflammatory bowel disease, pro-inflammatory mediators, neuroprotection
- MeSH terms
- Animals, Enterochromaffin Cells, Humans, Inflammation, Serotonin, Inflammatory Bowel Diseases, Enteric Nervous System, Serotonergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
