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Cited by 165Gastrointestinal motility and disordersInflammatory Bowel DiseaseGut microbiota and health

Immune dysfunction in patients with functional gastrointestinal disorders

Kindt, S., Van Oudenhove, L., Broekaert, D., Kasran, A., Ceuppens, J. L., Bossuyt, X., Fischler, B., Tack, J.·2009·Neurogastroenterology & Motility
DOI 10.1111/j.1365-2982.2008.01220.x
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Abstract

Abstract There is increasing evidence for involvement of the immune system in functional gastrointestinal disorder (FGID), including onset after acute gastrointestinal infections, genotypes resulting in altered cytokine expression and abnormal presence of immune cells. Our aim was to assess cellular and humoral immune responses in (i) FGIDs, compared to healthy subjects and (ii) acute vs unspecified onset FGIDs. Lymphocytic [interleukin (IL)‐5, IL‐10, IL‐13 and interferon γ (IFN‐γ)] and monocytic [IL‐10, IL‐12, tumour necrosis factor (TNF)‐α] cytokine production was characterized at baseline and after stimulation with phytohemagglutinine and anti‐CD28 or lipopolysaccharide (LPS) in controls (n = 32), irritable bowel syndrome (IBS) (n = 30), functional dyspepsia (FD) (n = 23) and non‐cardiac chest pain (NCCP) (n = 15). Serum IL‐6 and IL‐10 concentrations were compared, and the immunophenotype was assessed using fluorescent‐activated cell sorter. Findings were compared for acute vs unspecified onset FGID. Compared to controls, stimulated lymphocyte expression of IL‐5 and IL‐13 was enhanced in IBS, FD and NCCP (all P < 0.05). Conversely, the stimulated monocytic IL‐12 and lymphocytic IL‐10 expression were reduced in IBS and FD, while IFN‐γ expression was also reduced in FD patients. Except for an increase in the numbers of CD3+CD45RA+CD45RO+ cells, no distinct cellular profile was detected. Patients with a presumed acute onset of their symptoms had higher serum IL‐10 levels and more CD3+CD45RA+CD45RO+ cells, while TNF‐α levels following stimulation with LPS were higher in FD patients reporting an acute onset. A shift towards a Th2 cytokine profile is present in FGID, while the cellular immunophenotype remains largely unchanged. Further research is indicated and could provide new therapeutic strategies for these disorders.

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Crossref · 10.1111/j.1365-2982.2008.01220.x

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  • Overall, alterations in cytokine secretion by stimulated peripheral blood cells appear to favor an activated immune state and an altered immune response shifted toward a T-helper 2 phenotype in IBS patients.

    “Overall, it seems that alterations in cytokine secretion by stimulated peripheral blood cells appear to favor an activated immune state (98, 122), and an altered immune response shifted toward a T-helper 2 phenotype(90) in IBS patients.”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [90]

  • Cytokine secretion following in vitro stimulation of peripheral blood lymphocytes/monocytes may also be altered in patients with IBS.

    “Cytokine secretion following in vitro stimulation of peripheral blood lymphocytes/monocytes may also be altered in patients with IBS (90, 98, 122).”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [90]

  • Other studies did not observe differences in IL-10 levels between IBS patients and controls.

    “However, other studies did not observe differences in IL-10 levels between IBS patients and controls (50, 51, 90), leaving the relevance of IL-10 levels in patients with IBS unclear.”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [90]

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Authors
Kindt, S., Van Oudenhove, L., Broekaert, D., Kasran, A., Ceuppens, J. L., Bossuyt, X., Fischler, B., & Tack, J.
Affiliations
KU Leuven (BE)
Corresponding author
Tack, J.
ORCID
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2009-03-11
Volume
21
Issue
4
Pages
389-398
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
DOI
10.1111/j.1365-2982.2008.01220.x
OpenAlex
W1993145105
Cited by
165
References
33
Citations by year
2026: 3 · 2025: 4 · 2024: 10 · 2023: 11 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 12 · 2015: 15 · 2014: 11 · 2013: 10 · 2012: 16
FWCI
9.87
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (KU Leuven) (submittedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Funders
  • Fonds Wetenschappelijk Onderzoek
  • Vlaamse regering
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
functional gastrointestinal disorders, immune dysfunction, irritable bowel syndrome, functional dyspepsia, non-cardiac chest pain, cytokines, Th2 immune response, acute onset, lymphocyte subsets, IL-10, IL-5, IL-13, interferon-gamma, TNF-α, IL-12, lipopolysaccharide stimulation, phytohemagglutinin
MeSH terms
Adult, Anxiety, Depression, Enzyme-Linked Immunosorbent Assay, Female, Gastrointestinal Diseases, Humans, Hypersensitivity, Lymphocytes, Male, Middle Aged, Antigens, CD, Prevalence, Immunophenotyping, Cytokines

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