Cited by 476Gastrointestinal motility and disordersGut microbiota and healthInfant Health and Development

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Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

tana, c., umesaki, y., imaoka, a., handa, t., kanazawa, m., fukudo, s.·2009·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2009.01427.x

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Abstract

BACKGROUND: The profile of intestinal organic acids in irritable bowel syndrome (IBS) and its correlation with gastrointestinal (GI) symptoms are not clear. We hypothesized in this study that altered GI microbiota contribute to IBS symptoms through increased levels of organic acids. METHODS: Subjects were 26 IBS patients and 26 age- and sex-matched controls. Fecal samples were collected for microbiota analysis using quantitative real-time polymerase chain reaction and culture methods, and the determination of organic acid levels using high-performance liquid chromatography. Abdominal gas was quantified by image analyses of abdominal X-ray films. Subjects completed a questionnaire for GI symptoms, quality of life (QOL) and negative emotion. KEY RESULTS: Irritable bowel syndrome patients showed significantly higher counts of Veillonella (P = 0.046) and Lactobacillus (P = 0.031) than controls. They also expressed significantly higher levels of acetic acid (P = 0.049), propionic acid (P = 0.025) and total organic acids (P = 0.014) than controls. The quantity of bowel gas was not significantly different between controls and IBS patients. Finally, IBS patients with high acetic acid or propionic acid levels presented with significantly worse GI symptoms, QOL and negative emotions than those with low acetic acid or propionic acid levels or controls. CONCLUSIONS & INFERENCES: These results support the hypothesis that both fecal microbiota and organic acids are altered in IBS patients. A combination of Veillonella and Lactobacillus is known to produce acetic and propionic acid. High levels of acetic and propionic acid may associate with abdominal symptoms, impaired QOL and negative emotions in IBS.

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Authors: tana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S.
Affiliations: Tohoku University (JP)
Yakult Central Institute (JP)
Corresponding author: fukudo, s.
ORCID: umesaki, y.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2009-11
Volume: 22
Issue: 5
Pages: 512-9, e114
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2009.01427.x
OpenAlex: W1974577714
Cited by: 474
References: 45
Citations by year: 2026: 6 · 2025: 21 · 2024: 30 · 2023: 19 · 2022: 35 · 2021: 38 · 2020: 31 · 2019: 34 · 2018: 27 · 2017: 29 · 2016: 39 · 2015: 32 · 2014: 38 · 2013: 29 · 2012: 23
FWCI: 23.01
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2130 d)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Keywords: irritable bowel syndrome, gut microbiota, organic acids, acetic acid, propionic acid, Veillonella, Lactobacillus, gastrointestinal symptoms, quality of life, negative emotions, abdominal gas, fecal microbiota
MeSH terms: Adult, Analysis of Variance, Chromatography, High Pressure Liquid, DNA, Bacterial, Feces, Female, Humans, Immunoenzyme Techniques, Lactobacillus, Male, Propionates, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Veillonella, Case-Control Studies, Statistics, Nonparametric, Acetic Acid, Reverse Transcriptase Polymerase Chain Reaction, Irritable Bowel Syndrome, Metagenome

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Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

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