Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome
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BACKGROUND: Fecal metabolites are associated with gut visceral sensitivity, mucosal immune function and intestinal barrier function, all of which have critical roles in the pathogenesis of irritable bowel syndrome (IBS). However, the metabolic profile and pathophysiology of IBS are still unclear. We hypothesized that altered profiles of fecal metabolites might be involved in the pathogenesis of IBS with predominant diarrhea (IBS-D). AIM: To investigate the fecal metabolite composition and the role of metabolites in IBS-D pathophysiology. METHODS: Thirty IBS-D patients and 15 age- and sex-matched healthy controls (HCs) underwent clinical and psychological assessments, including the IBS Symptom Severity System (IBS-SSS), an Italian modified version of the Bowel Disease Questionnaire, the Bristol Stool Form Scale (BSFS), the Hospital Anxiety and Depression Scale, and the Visceral Sensitivity Index. Visceral sensitivity to rectal distension was tested using high-resolution manometry system by the same investigator. Fecal metabolites, including amino acids and organic acids, were measured by targeted metabolomics approaches. Correlation analyses between these parameters were performed. RESULTS: < 0.001). In this regression model, the levels of Tyr, Val, hexanoate, fumarate, and pyruvate were significantly associated with the symptom severity of IBS-D. Furthermore, visceral sensation, including abdominal pain and visceral hypersensitivity, was correlated with isovalerate, valerate and isohexanoate. CONCLUSION: increasing visceral sensitivity.
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In patients with irritable bowel syndrome, concentrations of isovalerate and valerate were positively associated with abdominal pain and hypersensitivity.
“In patients with irritable bowel syndrome, concentrations of isovalerate and valerate were positively associated with abdominal pain and hypersensitivity (385).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [385]
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- Authors
- Zhang, W.-X., Zhang, Y., Qin, G., Li, K.-M., Wei, W., Li, S.-Y., & Yao, S.-K.
- Affiliations
- Qingdao University (CN)
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2019-11-21
- Volume
- 25
- Issue
- 43
- Pages
- 6416-6429
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC6881512
- OpenAlex
- W2989970781
- Cited by
- 32
- References
- 72
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 3
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- diarrhea-predominant irritable bowel syndrome, fecal metabolites, visceral hypersensitivity, visceral sensitivity, symptom severity, amino acids, organic acids, isovalerate, valerate, tyrosine, valine, fumarate, pyruvate, hexanoate, rectal distension, abdominal pain, gut-brain axis
- MeSH terms
- Adult, Carboxylic Acids, Feces, Female, Humans, Male, Severity of Illness Index, Abdominal Pain, Case-Control Studies, Irritable Bowel Syndrome
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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