Cited by 476Gastrointestinal motility and disordersGut microbiota and healthInfant Health and Development

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

tana, c., umesaki, y., imaoka, a., handa, t., kanazawa, m., fukudo, s.·2009·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2009.01427.x

Open this paper in CoChat — free account

Abstract

BACKGROUND: The profile of intestinal organic acids in irritable bowel syndrome (IBS) and its correlation with gastrointestinal (GI) symptoms are not clear. We hypothesized in this study that altered GI microbiota contribute to IBS symptoms through increased levels of organic acids. METHODS: Subjects were 26 IBS patients and 26 age- and sex-matched controls. Fecal samples were collected for microbiota analysis using quantitative real-time polymerase chain reaction and culture methods, and the determination of organic acid levels using high-performance liquid chromatography. Abdominal gas was quantified by image analyses of abdominal X-ray films. Subjects completed a questionnaire for GI symptoms, quality of life (QOL) and negative emotion. KEY RESULTS: Irritable bowel syndrome patients showed significantly higher counts of Veillonella (P = 0.046) and Lactobacillus (P = 0.031) than controls. They also expressed significantly higher levels of acetic acid (P = 0.049), propionic acid (P = 0.025) and total organic acids (P = 0.014) than controls. The quantity of bowel gas was not significantly different between controls and IBS patients. Finally, IBS patients with high acetic acid or propionic acid levels presented with significantly worse GI symptoms, QOL and negative emotions than those with low acetic acid or propionic acid levels or controls. CONCLUSIONS & INFERENCES: These results support the hypothesis that both fecal microbiota and organic acids are altered in IBS patients. A combination of Veillonella and Lactobacillus is known to produce acetic and propionic acid. High levels of acetic and propionic acid may associate with abdominal symptoms, impaired QOL and negative emotions in IBS.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2982.2009.01427.x

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
(1992) · PubMed · Cited by 33,716
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
A self-rating depression scale
ZUNG, W. W. K. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01720310065008 · Cited by 9,813
The twenty-item Toronto Alexithymia Scale--I. Item selection and cross-validation of the factor structure
Bagby, R. M., Parker, J. D. A., & Taylor, G. J. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90005-1 · Cited by 5,293
Functional Bowel Disorders
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Psychological Stress and Susceptibility to the Common Cold
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108293250903 · Cited by 1,712
The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress
FRANCIS, C. Y., MORRIS, J., & WHORWELL, P. J. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.142318000.x · Cited by 1,708
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
GSRS—A clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease
Svedlund, J., Sjödin, I., & Dotevall, G. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01535722 · Cited by 1,319

Show all 45 references

Research works printed but not linked: 2

Speilberger, 1970, STAI Manual, 23
Brierley, 2008, Novel and specific roles for the inon channel TRPA1 in visceral sensory transduction, Gastroenterology, 134

Sorted by citations

The human microbiome: at the interface of health and disease
Cho, I., & Blaser, M. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3182 · Cited by 3,449
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611
The first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182
Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041
Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity
Gupta, V. K., Paul, S., & Dutta, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01162 · Cited by 1,019
Brain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 788
Intestinal microbiota in human health and disease: the impact of probiotics
Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724
Gut Microbiota in Patients With Irritable Bowel Syndrome—A Systematic Review
Pittayanon, R., Lau, J. T., Yuan, Y., Leontiadis, G. I., Tse, F., Surette, M., & Moayyedi, P. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.049 · Cited by 719
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome
Saulnier, D. M., Riehle, K., Mistretta, T., Diaz, M., Mandal, D., Raza, S., Weidler, E. M., Qin, X., Coarfa, C., Milosavljevic, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.072 · Cited by 672
Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior
Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632
“Given the high comorbidity of GI and mood disorders, it makes sense that drugs targeting the serotonergic system effectively treat the symptoms of IBS and anxiety and depressive disorders (O’Mahony et al., 2015).”
BackgroundInfluential
Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis
Tojo, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15163 · Cited by 533
Biopsychosocial Aspects of Functional Gastrointestinal Disorders: How Central and Environmental Processes Contribute to the Development and Expression of Functional Gastrointestinal Disorders
Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B., & Naliboff, B. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.027 · Cited by 512
Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice
De Palma, G., Lynch, M. D. J., Lu, J., Dang, V. T., Deng, Y., Jury, J., Umeh, G., Miranda, P. M., Pigrau Pastor, M., Sidani, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6397 · Cited by 505
Neuropeptide, Y, peptide YY and pancreatic polypeptide in the gut-brain axis
Holzer, P., Reichmann, F., & Farzi, A. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.08.005 · Cited by 501
Brain gut microbiome interactions and functional bowel disorders
Mayer, E. A., Savidge, T., & Shulman, R. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.037 · Cited by 496
The microbiome: stress, health and disease
Moloney, R. D., Desbonnet, L., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Mammalian Genome · doi:10.1007/s00335-013-9488-5 · Cited by 430
Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications
Facchin, S., Bertin, L., Bonazzi, E., Lorenzon, G., Barba, C. D., Barberio, B., Zingone, F., Maniero, D., Scarpa, M., Ruffolo, C., et al. (2024) · Life · doi:10.3390/life14050559 · Cited by 455
The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS
Staudacher, H. M., & Whelan, K. (2017) · Gut · doi:10.1136/gutjnl-2017-313750 · Cited by 398
Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation
Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.10.005 · Cited by 396
Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome
Moloney, R. D., Johnson, A. C., O’Mahony, S. M., Dinan, T. G., Meerveld, B. G., & Cryan, J. F. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12490 · Cited by 412
Thirty Years of Lactobacillus rhamnosus GG
Capurso, L. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001170 · Cited by 400
Functional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome
Chassard, C., Dapoigny, M. C., Scott, K. P., Crouzet, L., Del’Homme, C., Marquet, P., Martin, J. C., Pickering, G. P., Ardid, D., Eschalier, A., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05007.x · Cited by 377
Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?
Rajilić-Stojanović, M., Jonkers, D. M., Salonen, A., Hanevik, K., Raes, J., Jalanka, J., de Vos, W. M., Manichanh, C., Golic, N., Enck, P., et al. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.427 · Cited by 359
A role for the gut microbiota in IBS
Collins, S. M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.40 · Cited by 351
Intestinal Microbiota in Healthy Adults: Temporal Analysis Reveals Individual and Common Core and Relation to Intestinal Symptoms
Jalanka-Tuovinen, J., Salonen, A., Nikkilä, J., Immonen, O., Kekkonen, R., Lahti, L., Palva, A., & de Vos, W. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023035 · Cited by 340
'Gut health': a new objective in medicine?
Bischoff, S. C. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-24 · Cited by 338
Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome
Giloteaux, L., Goodrich, J. K., Walters, W. A., Levine, S. M., Ley, R. E., & Hanson, M. R. (2016) · Microbiome · doi:10.1186/s40168-016-0171-4 · Cited by 339
The Microbiome and Irritable Bowel Syndrome – A Review on the Pathophysiology, Current Research and Future Therapy
Chong, P. P., Chin, V. K., Looi, C. Y., Wong, W. F., Madhavan, P., & Yong, P. V. C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01136 · Cited by 353
The Intestinal Microenvironment and Functional Gastrointestinal Disorders
Barbara, G., Feinle-Bisset, C., Ghoshal, U. C., Santos, J., Vanner, S. J., Vergnolle, N., Zoetendal, E. G., & Quigley, E. M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.028 · Cited by 335
Irritable bowel syndrome: A microbiome-gut-brain axis disorder?
Kennedy, P. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14105 · Cited by 347
The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential
Borre, Y. E., Moloney, R. D., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_17 · Cited by 329
Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome
Pozuelo, M., Panda, S., Santiago, A., Mendez, S., Accarino, A. M., Santos, J., Guarner, F., Azpiroz, F., & Manichanh, C. (2015) · Scientific Reports · doi:10.1038/srep12693 · Cited by 338
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320
The intestinal microbiota and chronic disorders of the gut
Dupont, A. W., & DuPont, H. L. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.133 · Cited by 310
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300
Irritable bowel syndrome: a gut microbiota-related disorder?
Bhattarai, Y., Muniz Pedrogo, D. A., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2016 · Cited by 294
Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders
Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103740 · Cited by 294
Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome
Carroll, I. M., Ringel-Kulka, T., Keku, T. O., Chang, Y.-H., Packey, C. D., Sartor, R. B., & Ringel, Y. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2011 · Cited by 292
A review of metabolic potential of human gut microbiome in human nutrition
Yadav, M., Verma, M. K., & Chauhan, N. S. (2017) · Archives of Microbiology · doi:10.1007/s00203-017-1459-x · Cited by 295
Peripheral Mechanisms in Irritable Bowel Syndrome
Kassam, Z., Collins, S. M., & Moayyedi, P. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1214185 · Cited by 285
The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota
Crouzet, L., Gaultier, E., Del'Homme, C., Cartier, C., Delmas, E., Dapoigny, M., Fioramonti, J., & Bernalier‐Donadille, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12103 · Cited by 280
Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
Salonen, A., de Vos, W. M., & Palva, A. (2010) · Microbiology · doi:10.1099/mic.0.043257-0 · Cited by 264
Gut microbiota: next frontier in understanding human health and development of biotherapeutics
Prakash, S., Rodes, L., Coussa-Charley, M., Tomaro-Duchesneau, C., Tomaro-Duchesneau, C., Coussa-Charley, & Rodes (2011) · Biologics · doi:10.2147/btt.s19099 · Cited by 283
Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders
MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.28177 · Cited by 263
Lactobacillus and intestinal diseases: Mechanisms of action and clinical applications
Huang, R., Wu, F. L., Zhou, Q., Wei, W., Juan, Y., Xiao, B., & Luo, Z. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127019 · Cited by 268
Gut Microbiota and Their Metabolites in Stroke: A Double-Edged Sword
Peh, A., O’Donnell, J. A., Broughton, B. R. S., & Marques, F. Z. (2022) · Stroke · doi:10.1161/strokeaha.121.036800 · Cited by 260
Altered molecular signature of intestinal microbiota in irritable bowel syndrome patients compared with healthy controls: A systematic review and meta-analysis
Liu, H.-N., Wu, H., Chen, Y.-Z., Chen, Y.-J., Shen, X.-Z., & Liu, T.-T. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.01.142 · Cited by 254
Microbial community and metabolomic comparison of irritable bowel syndrome faeces
Ponnusamy, K., Choi, J. N., Kim, J., Lee, S., & Lee, C. H. (2011) · Journal of Medical Microbiology · doi:10.1099/jmm.0.028126-0 · Cited by 249
Gut Microbial Dysbiosis in the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies
Wang, L., Alammar, N., Singh, R., Nanavati, J., Song, Y., Chaudhary, R., & Mullin, G. E. (2019) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.05.015 · Cited by 251
Characterization of the Fecal Microbiota Using High-Throughput Sequencing Reveals a Stable Microbial Community during Storage
Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., Klaenhammer, T. R., & Ringel, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046953 · Cited by 241
S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM)
Layer, P., Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S., Claßen, M., Enck, P., Frieling, T., Haag, S., Holtmann, G., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0029-1245976 · Cited by 236
Irritable Bowel Syndrome, Gut Microbiota and Probiotics
Lee, B. J., & Bak, Y. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.3.252 · Cited by 229
Strict vegetarian diet improves the risk factors associated with metabolic diseases by modulating gut microbiota and reducing intestinal inflammation
Kim, M., Hwang, S., Park, E., & Bae, J. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12079 · Cited by 220
A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies
Rodiño‐Janeiro, B. K., Vicario, M., Alonso, C., Pascua-García, R., & Santos, J. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0673-5 · Cited by 223
Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrome
Rigsbee, L., Agans, R., Shankar, V., Kenche, H., Khamis, H. J., Michail, S., & Paliy, O. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.287 · Cited by 207
Evidence-based clinical practice guidelines for irritable bowel syndrome
Fukudo, S., Kaneko, H., Akiho, H., Inamori, M., Endo, Y., Okumura, T., Kanazawa, M., Kamiya, T., Sato, K., Chiba, T., et al. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-1017-0 · Cited by 208
Self-citation
Luminal and mucosal-associated intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome
Carroll, I. M., Chang, Y.-H., Park, J., Sartor, R. B., & Ringel, Y. (2010) · Gut Pathogens · doi:10.1186/1757-4749-2-19 · Cited by 203
Evidence-based clinical practice guidelines for irritable bowel syndrome 2020
Fukudo, S., Okumura, T., Inamori, M., Okuyama, Y., Kanazawa, M., Kamiya, T., Sato, K., Shiotani, A., Naito, Y., Fujikawa, Y., et al. (2021) · Journal of Gastroenterology · doi:10.1007/s00535-020-01746-z · Cited by 201
Self-citation
Alterations of gut microbiota in patients with irritable bowel syndrome: A systematic review and meta‐analysis
Zhuang, X., Xiong, L., Li, L., Li, M., & Chen, M. (2016) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13471 · Cited by 191
Irritable bowel syndrome: Emerging paradigm in pathophysiology
Lee, Y. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2456 · Cited by 190
Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies
Bokoliya, S. C., Dorsett, Y., Panier, H. A., & Zhou, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.711055 · Cited by 194
Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
Öhman, L., Törnblom, H., & Simrén, M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.200 · Cited by 185
Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review
Dale, H. F., Rasmussen, S. H., Asiller, Ö. Ö., & Lied, G. A. (2019) · Nutrients · doi:10.3390/nu11092048 · Cited by 169
Stress-Induced Visceral Pain: Toward Animal Models of Irritable-Bowel Syndrome and Associated Comorbidities
Moloney, R. D., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00015 · Cited by 171
Analysis of short-chain fatty acids in human feces: A scoping review
Primec, M., Mičetić‐Turk, D., & Langerholc, T. (2017) · Analytical Biochemistry · doi:10.1016/j.ab.2017.03.007 · Cited by 171
An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome
Ahmed, I., Greenwood, R., Costello, B. D. L., Ratcliffe, N. M., & Probert, C. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058204 · Cited by 163
Gut Microbiota-Derived Metabolites in Irritable Bowel Syndrome
Xiao, L., Liu, Q., Luo, M., & Xiong, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.729346 · Cited by 168
Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome
Chumpitazi, B. P., Hollister, E. B., Oezguen, N., Tsai, C. M., McMeans, A. R., Luna, R. A., Savidge, T. C., Versalovic, J., & Shulman, R. J. (2014) · Gut Microbes · doi:10.4161/gmic.27923 · Cited by 156
Gut Microbiota Dysbiosis as Risk and Premorbid Factors of IBD and IBS Along the Childhood–Adulthood Transition
Putignani, L., CHIERICO, F. D., Vernocchi, P., Cicala, M., Cucchiara, S., & Dallapiccola, B. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000602 · Cited by 153
Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?
Hughes, P. A., Zola, H., Penttila, I., Blackshaw, L. A., Andrews, J. M., & Krumbiegel, D. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.120 · Cited by 147
Fecal Microbiota in Patients with Irritable Bowel Syndrome Compared with Healthy Controls Using Real-Time Polymerase Chain Reaction: An Evidence of Dysbiosis
Shukla, R., Ghoshal, U., Dhole, T. N., & Ghoshal, U. C. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3607-y · Cited by 147
The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe?
Ghoshal, U. C., Shukla, R., Ghoshal, U., Gwee, K., Ng, S. C., & Quigley, E. M. M. (2012) · International Journal of Inflammation · doi:10.1155/2012/151085 · Cited by 144
Altered Colonic Bacterial Fermentation as a Potential Pathophysiological Factor in Irritable Bowel Syndrome
Ringel‐Kulka, T., Choi, C. H., Temas, D., Kim, A., Maier, D. M., Scott, K. P., Galanko, J. A., & Ringel, Y. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.220 · Cited by 142
Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome
Bennet, S., Öhman, L., & Simrén, M. (2015) · Gut and Liver · doi:10.5009/gnl14344 · Cited by 144
Chronic Functional Bowel Syndrome Enhances Gut-Brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and Vulnerability to Dementia
Daulatzai, M. A. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1266-6 · Cited by 143
Effects of sc FOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double blind, placebo controlled study
Azpiroz, F., Dubray, C., Bernalier‐Donadille, A., Cardot, J. ‐., Accarino, A. M., Serra, J., Wagner, A., Respondek, F., & Dapoigny, M. C. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12911 · Cited by 149
Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome
Sun, Q., Jia, Q., Song, L., & Duan, L. (2019) · Medicine · doi:10.1097/md.0000000000014513 · Cited by 141
Germ‐free mice as a model to study effect of gut microbiota on host physiology
Grover, M., & Kashyap, P. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12366 · Cited by 142
Fecal Microbiota Alterations Associated With Diarrhea-Predominant Irritable Bowel Syndrome
Zhuang, X., Tian, Z., Li, L., Zeng, Z., Chen, M., & Xiong, L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01600 · Cited by 137
Impact of microbial transformation of food on health — from fermented foods to fermentation in the gastro-intestinal tract
Vlieg, J. E. V. H., Veiga, P., Zhang, C., Derrien, M., & Zhao, L. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.12.004 · Cited by 136
Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome
Compare, D., Rocco, A., Coccoli, P., Angrisani, D., Sgamato, C., Iovine, B., Salvatore, U., & Nardone, G. (2017) · BMC Gastroenterology · doi:10.1186/s12876-017-0605-x · Cited by 133
Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders
Fukui, H., Xu, X., & Miwa, H. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18071 · Cited by 128
Disruption of the Human Gut Microbiota following Norovirus Infection
Nelson, A. M., Walk, S. T., Taube, S., Taniuchi, M., Houpt, E. R., Wobus, C. E., & Young, V. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048224 · Cited by 128
The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial
Sun, Y.-Y., Li, M., Li, Y.-Y., Li, L.-X., Zhai, W.-Z., Wang, P., Yang, X.-X., Gu, X., Song, L.-J., Li, Z., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21241-z · Cited by 126
Defecation frequency and cardiovascular disease mortality in Japan: The Ohsaki cohort study
Honkura, K., Tomata, Y., Sugiyama, K., Kaiho, Y., Watanabe, T., Zhang, S., Sugawara, Y., & Tsuji, I. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.007 · Cited by 127
Altered gastrointestinal microbiota in irritable bowel syndrome and its modification by diet: probiotics, prebiotics and the low FODMAP diet
Staudacher, H. M., & Whelan, K. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000021 · Cited by 133
Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome
Ringel, Y., & Maharshak, N. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00207.2012 · Cited by 115
Gut Microbiota Composition Before and After Use of Proton Pump Inhibitors
Hojo, M., Asahara, T., Nagahara, A., Takeda, T., Matsumoto, K., Ueyama, H., Matsumoto, K., Asaoka, D., Takahashi, T., Nomoto, K., et al. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5122-4 · Cited by 114
Recent developments in the pathophysiology of irritable bowel syndrome
El-Salhy, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i25.7621 · Cited by 111
Fecal and Mucosa-Associated Intestinal Microbiota in Patients with Diarrhea-Predominant Irritable Bowel Syndrome
Maharshak, N., Ringel, Y., Katibian, D., Lundqvist, A., Sartor, R. B., Carroll, I. M., & Ringel‐Kulka, T. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5086-4 · Cited by 109
Intestinal microbiota in pathophysiology and management of irritable bowel syndrome.
(2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8886 · Cited by 106
Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome
Hasler, W. L., Grabauskas, G., Singh, P., & Owyang, C. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14339 · Cited by 105
Faecal short-chain fatty acids - a diagnostic biomarker for irritable bowel syndrome?
Farup, P. G., Rudi, K., & Hestad, K. A. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0446-z · Cited by 109
Differences of microbiota in small bowel and faeces between irritable bowel syndrome patients and healthy subjects
Chung, C., Chang, P., Liao, C., Lee, T., Chen, Y., Lee, Y., Wu, M., Wang, H., & Ni, Y. (2015) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2015.1116107 · Cited by 105
Fecal Clostridiales distribution and short‐chain fatty acids reflect bowel habits in irritable bowel syndrome
Gargari, G., Taverniti, V., Gardana, C., Cremon, C., Canducci, F., Pagano, I., Barbaro, M. R., Bellacosa, L., Castellazzi, A. M., Valsecchi, C., et al. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14271 · Cited by 102
Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model
Ihekweazu, F. D., Fofanova, T. Y., Queliza, K., Nagy‐Szakal, D., Stewart, C. J., Engevik, M. A., Hultén, K. G., Tatevian, N., Graham, D. Y., Versalovic, J. A., et al. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1560753 · Cited by 99
Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis
Carco, C., Young, W., Gearry, R. B., Talley, N. J., McNabb, W. C., & Roy, N. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00468 · Cited by 105

Authors: tana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S.
Affiliations: Tohoku University (JP)
Yakult Central Institute (JP)
Corresponding author: fukudo, s.
ORCID: umesaki, y.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2009-11
Volume: 22
Issue: 5
Pages: 512-9, e114
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2009.01427.x
OpenAlex: W1974577714
Cited by: 474
References: 45
Citations by year: 2026: 6 · 2025: 21 · 2024: 30 · 2023: 19 · 2022: 35 · 2021: 38 · 2020: 31 · 2019: 34 · 2018: 27 · 2017: 29 · 2016: 39 · 2015: 32 · 2014: 38 · 2013: 29 · 2012: 23
FWCI: 23.01
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2130 d)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Keywords: irritable bowel syndrome, gut microbiota, organic acids, acetic acid, propionic acid, Veillonella, Lactobacillus, gastrointestinal symptoms, quality of life, negative emotions, abdominal gas, fecal microbiota
MeSH terms: Adult, Analysis of Variance, Chromatography, High Pressure Liquid, DNA, Bacterial, Feces, Female, Humans, Immunoenzyme Techniques, Lactobacillus, Male, Propionates, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Veillonella, Case-Control Studies, Statistics, Nonparametric, Acetic Acid, Reverse Transcriptase Polymerase Chain Reaction, Irritable Bowel Syndrome, Metagenome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks