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MTP1-dependent Zn sequestration into shoot vacuoles suggests dual roles in Zn tolerance and accumulation in Zn-hyperaccumulating plants
Open accessAbstract
The integral membrane protein Thlaspi goesingense metal tolerance protein 1 (TgMTP1) has been suggested to play an important role in Zn hyperaccumulation in T. goesingense. Here, we show that the TgMTP1 protein is accumulated to high levels at the vacuolar membrane in shoot tissue of T. goesingense. TgMTP1 is likely to act in the transport of Zn into the vacuole, enhancing both Zn accumulation and tolerance. By specifically expressing TgMTP1 in Arabidopsis thaliana shoots, we show that TgMTP1, localized at the vacuolar membrane, can drive the enhanced shoot accumulation of Zn by initiating a systemic Zn deficiency response. The systematic response includes increased expression of Zn transporters (ZIP3, ZIP4, ZIP5 and ZIP9) in both shoot and root tissue. Furthermore, shoot-specific accumulation of TgMTP1 at the vacuolar membrane also leads to increased resistance to Zn in A. thaliana, probably through enhanced Zn compartmentalization in the vacuole. Such evidence leads to the conclusion that the high levels of TgMTP1 at the vacuolar membrane in shoot tissue of the Zn hyperaccumulator T. goesingense play a role in both Zn tolerance and enhanced Zn uptake and accumulation, via the activation of a systemic Zn deficiency response.
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“Moreover, MTP1 was overexpressed in A. halleri and N. caerulescens to transport Zn and Cd (Dräger et al., 2004; Gustin et al., 2009).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Gustin et al., 2009
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“The transformation of TgMTP1 in A. thaliana resulted in enhanced accumulation of Zn into vacuoles, attributing to Zn tolerance (Gustin et al., 2009).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Gustin et al., 2009
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Ponce‐Hernández, A., Alonso‐Castro, Á. J., la Cruz, R. F. G.-D., & Álvarez, C. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-89874-4.00012-1 · Cited by 2
Guerinot, M. L., Baxter, I. R., & Salt, D. E. (2017) · Annual Plant Reviews online · doi:10.1002/9781119312994.apr0381 · Cited by 2
Self-citationCardini, A., Pellegrino, E., White, P. J., Mazzolai, B., Mascherpa, M. C., & Ercoli, L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.11.088617 · Cited by 2
“Homologs of MsMTP1 and MsZIF1 were previously found to encode transporters loading Zn and NA into the vacuoles of Thlaspi geosingense and A. thaliana cells, respectively (Gustin et al., 2009; Haydon et al., 2012).”
Influential(2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384905-2.00028-5 · Cited by 2
Physiological, Biochemical, and Molecular Plant Responses to Zinc Deficiency and Excess
Kaur, H., Devi, K. S., Sunkaria, B., & Kaur, H. (2025) · Springer eBooks · doi:10.1007/978-981-96-4253-3_4 · Cited by 1
MdHMGB15 enhances zinc tolerance by activating multiple metal homeostasis genes in apple
Liu, R., Wang, M.-K., Wang, Y.-N., Qin, X.-H., Lv, Y.-X., Li, S.-S., Liu, D., Cong-yu, X., & Wang, X. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141677 · Cited by 1
Kumar, N., Tailor, A., Venkatraman, P., Kalita, E., Singh, I. K., & Singh, A. K. (2026) · ACS Omega · doi:10.1021/acsomega.5c13275 · Cited by 1
Phytoremediation Using Microbial Communities: I
Miransari, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-10969-5_14 · Cited by 1
Kim, D. (2015) · Journal of Plant Biotechnology · doi:10.5010/jpb.2015.42.4.409 · Cited by 1
“더구나 Gustin (2009)과 Kobae (2004) 가 이 유전자는 액포에 위치하고 있다고 보고했고, 우리 가 형질 과발현 시킨 이 변환체도 MTP1유전자를 액포에 발현시킬 가능성이 크기 때문에 식물정화공정에 아주 유 용하게 활용 가능성이 있다(Gustin et al. 2009; Kobae et al. 2004).”
InfluentialSelf-citationGrabsztunowicz, M., Stolarska, E., Tanwar, U. K., Arasimowicz‐Jelonek, M., & Sobieszczuk‐Nowicka, E. (2024) · Postępy Biochemii · doi:10.18388/pb.2021_559 · Cited by 1
Identification of regulatory factors determining nutrient acquisition in Arabidopsis
Giehl, R. F. H. (2012) · University writing server of the University of Hohenheim (Universität Hohenheim)
Palm, E. R. (2014) · ResearchWorks at the University of Washington (University of Washington)
Fizjologiczna funkcja białek CDF transportujących kationy metali u organizmów eukariotycznych
Małas, K., & Migocka, M. (2017)
Search for molecular mechanisms related to Zn accumulation and tolerance in Thlaspi caerulescens
Tuomainen, M. H. (2011) · UEF eRepo (University of Eastern Finland)
Bertrand, A. R., Detry, É., Nouet, C., Hanikenne, M., & Baurain, D. (2021) · Research Square · doi:10.21203/rs.3.rs-968648/v1
“, 2009)) and MTP1 (Zn vacuolar storage (Dräger et al., 2004; Gustin et al., 2009; Shahzad et al., 2010)).”
BackgroundSalt, D. E., & Chao, D. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.7064956.7284054
Self-citationPeng, J. I. N., Bokai, Y. A. N. G., Li, M., Liu, S., Xu, H., Wu, R. H., Guo, Y., & Yao, L. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5384936
Hydrophytes as a Source of Bioactives for Heavy Metals Remediation
Kaur, S., Kumar, A., & Raja, V. (2025) · IGI Global eBooks · doi:10.4018/979-8-3373-4037-1.ch004
van der Zee, L., Remigio, A. C., Casey, L. W., Purwadi, I., Yamjabok, J., van der Ent, A., Kootstra, G., & Aarts, M. G. M. (2021) · Figshare · doi:10.6084/m9.figshare.15102999
Peng, J. I. N., Bokai, Y. A. N. G., Li, M., Silin, L. I. U., Xu, H., Wu, R. H., Guo, Y., & Yao, L. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6431554
Metadata
- Authors
- Gustin, J. L., Loureiro, M. E., Kim, D., Na, G., Tikhonova, M., & Salt, D. E.
- Affiliations
- Purdue University West Lafayette (US)
- Universidade Federal de Viçosa (BR)
- Gyeongsang National University (KR)
- Corresponding author
- Salt, David E.
- ORCID
- Gustin, Jeffery L.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2009-03
- Volume
- 57
- Issue
- 6
- Pages
- 1116-1127
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2119893617
- Cited by
- 203
- References
- 46
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 4 · 2021: 24 · 2020: 18 · 2019: 15 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 14 · 2012: 11
- FWCI
- 14.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Plant Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Purdue University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Chemistry › Analytical Chemistry › Heavy Metals in Plants
- Keywords
- metal tolerance proteins, zinc hyperaccumulation, tonoplast, zinc tolerance, ZIP transporters, zinc uptake, Arabidopsis thaliana transformation, metal hyperaccumulator plants
- MeSH terms
- Amino Acid Sequence, Molecular Sequence Data, Plant Proteins, Vacuoles, Zinc, Sequence Alignment, Arabidopsis, Gene Expression Regulation, Plant, Plant Shoots, Cation Transport Proteins, Thlaspi
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