Exercise and skeletal muscle glucose transporter 4 expression: Molecular mechanisms

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works

Mitochondrial dysfunction and type 2 diabetes

Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works

Transcriptional regulation by calcium, calcineurin, and NFAT

Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991 · see citing works

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/386855a0 · Cited by 1,754 · see citing works

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/40912 · Cited by 1,521 · see citing works

Biochemical Adaptations in Muscle

Holloszy, J. O. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96046-1 · Cited by 1,517 · see citing works

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

McKinsey, T. A., Zhang, C., Lu, J., & Olson, E. N. (2000) · Nature · doi:10.1038/35040593 · Cited by 1,051 · see citing works

TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

Black, B. L., & Olson, E. N. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.167 · Cited by 1,037 · see citing works

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1

Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal · doi:10.1096/fj.02-0367com · Cited by 1,020 · see citing works

Molecular cloning and characterization of an insulin-regulatable glucose transporter

James, D. E., Strube, M., & Muecdler, M. (1989) · Nature · doi:10.1038/338083a0 · Cited by 909 · see citing works

MEF2: a calcium-dependent regulator of cell division, differentiation and death

McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)02031-x · Cited by 691 · see citing works

Activation of PPARγ Coactivator-1 Through Transcription Factor Docking

Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O’Malley, B. W., & Spiegelman, B. M. (1999) · Science · doi:10.1126/science.286.5443.1368 · Cited by 596 · see citing works

Dealing with energy demand: the AMP-activated protein kinase

Kemp, B. E., Mitchelhill, K. I., Stapleton, D., Michell, B. J., Chen, Z., & Witters, L. A. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01340-1 · Cited by 521 · see citing works

Nuclear targeting signal recognition: a key control point in nuclear transport?

Jans, D. A., Xiao, C.-Y., & Lam, M. H. C. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200006)22:6 · Cited by 519 · see citing works

Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

Lu, J., McKinsey, T. A., Nicol, R. L., & Olson, E. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080064097 · Cited by 518 · see citing works

Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle

Holmes, B. F., Kurth-Kraczek, E. J., & Winder, W. W. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.5.1990 · Cited by 489 · see citing works

Regulation of the MEF2 Family of Transcription Factors by p38

Zhao, M. F., New, L., Kravchenko, V. V., Kato, Y., Gram, H., Padova, F. D., Olson, E. N., Ulevitch, R. J., & Han, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.21 · Cited by 438 · see citing works

Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5

Czubryt, M. P., McAnally, J., Fishman, G. I., & Olson, E. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337639100 · Cited by 418 · see citing works

Control of muscle development by dueling HATs and HDACs

McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00224-0 · Cited by 414 · see citing works

Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans

Chen, Z.-P., Stephens, T. J., Murthy, S., Canny, B. J., Hargreaves, M., Witters, L. A., Kemp, B. E., & McConell, G. K. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2205 · Cited by 369 · see citing works

Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM

Pedersen, O., Bak, J. F., Andersen, P. H., Lund, S., Moller, D. E., Flier, J. S., & Kahn, B. B. (1990) · Diabetes · doi:10.2337/diab.39.7.865 · Cited by 329 · see citing works

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

Chang, C.-I., Xu, B.-E., Akella, R., Cobb, M. H., & Goldsmith, E. J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00525-7 · Cited by 302 · see citing works

PGC-1, a versatile coactivator

Knutti, D., & Kralli, A. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00457-x · Cited by 294 · see citing works

Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase

Zheng, D., MacLean, P. S., Pohnert, S. C., Knight, J. B., Olson, A. L., Winder, W. W., & Dohm, G. L. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1073 · Cited by 292 · see citing works

Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor

Knutti, D., Kressler, D., & Kralli, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171184698 · Cited by 271 · see citing works

Physical Training Increases Muscle GLUT4 Protein and mRNA in Patients With NIDDM

Dela, F., Ploug, T., Handberg, A., Petersen, L. N., Larsen, J. J., Mikines, K. J., & Galbo, H. (1994) · Diabetes · doi:10.2337/diab.43.7.862 · Cited by 252 · see citing works

Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle

Widegren, U., Jiang, X. J., Krook, A., Chibalin, A., Björnholm, M., Tally, M., Roth, R. A., Henriksson, J., Wallberg‐Henriksson, H., & Zierath, J. R. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.13.1379 · Cited by 242 · see citing works

Mechanism for Nucleocytoplasmic Shuttling of Histone Deacetylase 7

Kao, H., Verdel, A., Tsai, C., Simon, C. M., Juguilon, H., & Khochbin, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107631200 · Cited by 223 · see citing works

Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal Muscle

McGee, S. L., & Hargreaves, M. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1208 · Cited by 205 · see citing works

Mechanisms underlying the reduction of isometric force in skeletal muscle fatigue

Westerblad, H., Allen, D. G., Bruton, J. D., Andrade, F. H., & Lännergren, J. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0301f.x · Cited by 203 · see citing works

Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice

MARCHAND‐BRUSTEL, Y. L., Grémeaux, T., Ballotti, R., & OBBERGHEN, E. V. (1985) · Nature · doi:10.1038/315676a0 · Cited by 202 · see citing works

Myocyte Enhancer Factor 2 (MEF2)-Binding Site Is Required forGLUT4 Gene Expression in Transgenic Mice

Thai, M. V., Guruswamy, S., Cao, K. T., Pessin, J. E., & Olson, A. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14285 · Cited by 201 · see citing works

Signaling chromatin to make muscle

McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00389-7 · Cited by 198 · see citing works

Exercise induces a transient increase in transcription of the GLUT-4 gene in skeletal muscle

Neufer, P. D., & Dohm, G. L. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.6.c1597 · Cited by 192 · see citing works

Exercise Increases Ca2+–Calmodulin‐Dependent Protein Kinase II Activity in Human Skeletal Muscle

Rose, A. J., & Hargreaves, M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.054171 · Cited by 174 · see citing works

Mitogen‐activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction

Widegren, U., Ryder, J. W., & Zierath, J. R. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00855.x · Cited by 174 · see citing works

Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.

Ren, J., Marshall, B. A., Mueckler, M. M., McCaleb, M. L., Amatruda, J. M., & Shulman, G. I. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117673 · Cited by 171 · see citing works

Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle

McGee, S. L., Howlett, K. F., Starkie, R. L., Cameron-Smith, D., Kemp, B. E., & Hargreaves, M. (2003) · Diabetes · doi:10.2337/diabetes.52.4.926 · Cited by 160 · see citing works

Effects of exercise on GLUT-4 and glycogenin gene expression in human skeletal muscle

Kraniou, Y. N., Cameron‐Smith, D., Misso, M. L., Collier, G. R., & Hargreaves, M. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.2.794 · Cited by 153 · see citing works

Site of enhanced insulin sensitivity in exercise-trained rats at rest

Mondon, C. E., Dolkas, C. B., & Reaven, G. M. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.239.3.e169 · Cited by 125 · see citing works

Improvement of Insulin Action in Diabetic Transgenic Mice Selectively Overexpressing GLUT4 in Skeletal Muscle

Leturque, A., Loizeau, M., Vaulont, S., Salminen, M., & Girard, J. R. (1996) · Diabetes · doi:10.2337/diab.45.1.23 · Cited by 119 · see citing works

The MEF2A Isoform Is Required for Striated Muscle-specific Expression of the Insulin-responsive GLUT4 Glucose Transporter

Mora, S., & Pessin, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910259199 · Cited by 111 · see citing works

Regulation of the human GLUT4 gene promoter: Interaction between a transcriptional activator and myocyte enhancer factor 2A

Knight, J. B., Eyster, C. A., Griesel, B. A., & Olson, A. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2432756100 · Cited by 108 · see citing works

Exercise increases MEF2‐ and GEF DNA‐binding activities in human skeletal muscle

McGee, S. L., Sparling, D., Olson, A., & Hargreaves, M. (2006) · The FASEB Journal · doi:10.1096/fj.05-4671fje · Cited by 100 · see citing works

Identification of a 30-Base Pair Regulatory Element and Novel DNA Binding Protein That Regulates the Human GLUT4 Promoter in Transgenic Mice

Oshel, K. M., Knight, J. B., Cao, K. T., Thai, M. V., & Olson, A. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001452200 · Cited by 95 · see citing works

Ca2+ transients activate calcineurin/NFATc1 and initiate fast-to-slow transformation in a primary skeletal muscle culture

Kubis, H., Hanke, N., Scheibe, R. J., Meissner, J. D., & Gros, G. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00377.2002 · Cited by 85 · see citing works

Effect of fill-pulse parameters on deep-level transient spectroscopy peaks in highly doped p-type InP

Darwich, R., & Massarani, B. (2000) · Journal of Applied Physics · doi:10.1063/1.373804 · Cited by 67 · see citing works

Exercise, GLUT4, and skeletal muscle glucose uptake

Richter, E. A., & Hargreaves, M. (2013) · Physiological Reviews · doi:10.1152/physrev.00038.2012 · Cited by 1,407 · see citing works

Epigenetics: a molecular link between environmental factors and type 2 diabetes

Ling, C., & Groop, L. (2009) · Diabetes · doi:10.2337/db09-1003 · Cited by 617 · see citing works

Exercise, MAPK, and NF-κB signaling in skeletal muscle

Kramer, H. F., & Goodyear, L. J. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00085.2007 · Cited by 375 · see citing works

Epigenetics, DNA Methylation, and Chromatin Modifying Drugs

Moshe Szyf, A. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061008-103102 · Cited by 372 · see citing works

Epigenomics, gestational programming and risk of metabolic syndrome

Desai, M., Jellyman, J. K., & Ross, M. G. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.13 · Cited by 277 · see citing works

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

Nandipati, K. C., Subramanian, S., & Agrawal, D. K. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2878-8 · Cited by 210 · see citing works

Signaling of Mitochondrial Biogenesis following Oxidant Injury

Rasbach, K. A., & Schnellmann, R. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608009200 · Cited by 168 · see citing works

is-rSNP: a novel technique forin silicoregulatory SNP detection

Macintyre, G., Bailey, J., Haviv, I., & Kowalczyk, A. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq378 · Cited by 148 · see citing works

Epigenetic flexibility in metabolic regulation: disease cause and prevention

Kirchner, H., Osler, M. E., Krook, A., & Zierath, J. R. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.11.008 · Cited by 143 · see citing works

Epigenetic regulation on gene expression induced by physical exercise.

Ntanasis‐Stathopoulos, I., Tzanninis, J. G., Philippou, Α., & Koutsilieris, M. (2013) · PubMed · Cited by 132 · see citing works

Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations

Gruzman, A., Babai-Shani, G., & Sasson, S. (2009) · The Review of Diabetic Studies · doi:10.1900/rds.2009.6.13 · Cited by 128 · see citing works

Epigenetic adaptation to regular exercise in humans

Ling, C., & Rönn, T. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.03.006 · Cited by 114 · see citing works

AMP-Activated Protein Kinase Plays an Important Evolutionary Conserved Role in the Regulation of Glucose Metabolism in Fish Skeletal Muscle Cells

Magnoni, L., Vraskou, Y., Palstra, A., & Planas, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031219 · Cited by 108 · see citing works

The effect of exercise on skeletal muscle glucose uptake in type 2 diabetes: An epigenetic perspective

dos Santos, J. M., Moreli, M. L., Tewari, S., & Benite‐Ribeiro, S. A. (2015) · Metabolism · doi:10.1016/j.metabol.2015.09.013 · Cited by 107 · see citing works

Regulation of Energy Substrate Metabolism in Endurance Exercise

Alghannam, A. F., Ghaith, M. M., & Alhussain, M. H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094963 · Cited by 104 · see citing works

High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy

Imasawa, T., Obre, É., Bellancé, N., Lavie, J., Imasawa, T., Rigothier, C., Delmas, Y., Combe, C., Lacombe, D., Bénard, G., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600293r · Cited by 104 · see citing works

Molecular mechanisms by which aerobic exercise induces insulin sensitivity

Yaribeygi, H., Atkin, S. L., Simental‐Mendía, L. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28066 · Cited by 102 · see citing works

Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes

Chandrakumar, S., Paramasivam, P., Balakumar, M., Lenin, R. R., Prabhu, D., Anjana, R. M., Mohan, V., & Balasubramanyam, M. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0293-3 · Cited by 95 · see citing works

p38 Mitogen-activated Protein Kinase Plays an Inhibitory Role in Hepatic Lipogenesis

Xiong, Y., Collins, Q. F., An, J., Lupo, E. G., Liu, H. Y., Liu, D., Robidoux, J., Liu, Z., & Cao, W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606742200 · Cited by 93 · see citing works

Cerebral metabolism after forced or voluntary physical exercise

Kinni, H. A., Guo, M., Ding, J. Y., Konakondla, S., Dornbos, D., Tran, R., Guthikonda, M., & Ding, Y. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.076 · Cited by 91 · see citing works

KIN‐29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC

van der Linden, A. M., Nolan, K. M., & Sengupta, P. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601479 · Cited by 87 · see citing works

Small molecules from natural sources, targeting signaling pathways in diabetes

Liu, Q., Chen, L., Hu, L., Guo, Y., & Shen, X. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.06.004 · Cited by 86 · see citing works

Awareness of Hormesis Will Enhance Future Research in Basic and Applied Neuroscience

Mattson, M. P. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440802026406 · Cited by 81 · see citing works

Contraction Stimulates Nitric Oxide–Independent Microvascular Recruitment and Increases Muscle Insulin Uptake

Inyard, A. C., Clerk, L. H., Keske, M. A., & Barrett, E. J. (2007) · Diabetes · doi:10.2337/db07-0020 · Cited by 79 · see citing works

miR-103 promotes 3T3-L1 cell adipogenesis through AKT/mTOR signal pathway with its target being MEF2D

Li, M., Liu, Z., Zhang, Z., Liu, G., Sun, S., & Sun, C. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0241 · Cited by 79 · see citing works

p38 Mitogen-Activated Protein Kinase: A Critical Node Linking Insulin Resistance and Cardiovascular Diseases in Type 2 Diabetes Mellitus

Liu, Z., & Cao, W. (2009) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153009787582397 · Cited by 79 · see citing works

Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice

Anderson, C. M., Hu, J., Barnes, R. M., Heidt, A. B., Cornelissen, I., & Black, B. L. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0031-0 · Cited by 78 · see citing works

Genetic and epigenetic sex-specific adaptations to endurance exercise

Landen, S., Voisin, S., Craig, J. M., McGee, S. L., Lamon, S., & Eynon, N. (2019) · Epigenetics · doi:10.1080/15592294.2019.1603961 · Cited by 76 · see citing works

Caffeine induces hyperacetylation of histones at the MEF2 site on theGlut4promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism

Mukwevho, E., Kohn, T. A., Lang, D. M., Nyatia, E., Smith, J. A. H., & Ojuka, E. O. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00312.2007 · Cited by 75 · see citing works

Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients

Carvajal, R., Rosas, C., Kohan, K., Gabler, F., Vantman, D., Romero, C., & Vega, M. (2013) · Human Reproduction · doi:10.1093/humrep/det116 · Cited by 74 · see citing works

Hypoglycemic and hypolipidemic effects of total saponins from Stauntonia chinensis in diabetic db/db mice

Xu, J., Wang, S., Feng, T., Chen, Y., & Yang, G. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13876 · Cited by 70 · see citing works

Expression of myocyte enhancer factor-2 and downstream genes in ground squirrel skeletal muscle during hibernation

Tessier, S. N., & Storey, K. B. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0538-y · Cited by 66 · see citing works

Mechanisms of calcium-induced mitochondrial biogenesis and GLUT4 synthesis

Wright, D. C. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-062 · Cited by 68 · see citing works

Targeting Chromatin Remodeling for Cancer Therapy

Kaur, J., Daoud, A., & Eblen, S. T. (2019) · Current Molecular Pharmacology · doi:10.2174/1874467212666190215112915 · Cited by 65 · see citing works

A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise

Richter, E. A., Bilan, P. J., & Klip, A. (2025) · Physiological Reviews · doi:10.1152/physrev.00033.2024 · Cited by 64 · see citing works

High Density Lipoprotein (HDL) Promotes Glucose Uptake in Adipocytes and Glycogen Synthesis in Muscle Cells

Zhang, Q., Zhang, Y., Feng, H., Guo, R., Jin, L., Wan, R., Wang, L., Chen, C., & Li, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023556 · Cited by 64 · see citing works

Epigenetics and obesity: the devil is in the details

Franks, P. W., & Ling, C. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-88 · Cited by 62 · see citing works

Positive Aspects of Oxidative Stress at Different Levels of the Human Body: A Review

Jîtcă, G., Ősz, B. E., Tero-Vescan, A., Miklos, A., Rusz, C.-M., Bătrînu, M.-G., & Vari, C.-E. (2022) · Antioxidants · doi:10.3390/antiox11030572 · Cited by 64 · see citing works

The role of genetics and epigenetics in the pathogenesis of gestational diabetes mellitus

Rosik, J., Szostak, B., Machaj, F., & Pawlik, A. (2019) · Annals of Human Genetics · doi:10.1111/ahg.12356 · Cited by 67 · see citing works

Combatting type 2 diabetes by turning up the heat

Schrauwen, P., & Lichtenbelt, W. D. V. M. (2016) · Diabetologia · doi:10.1007/s00125-016-4068-3 · Cited by 59 · see citing works

The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both

Fernández-Morera, J. L., Rodríguez‐Rodero, S., Torre, E. L. M., & Fraga, M. F. (2010) · Obstetrics and Gynecology International · doi:10.1155/2010/605163 · Cited by 57 · see citing works

Effects of sustained swimming on the red and white muscle transcriptome of rainbow trout (Oncorhynchus mykiss) fed a carbohydrate-rich diet

Magnoni, L. J., Crespo, D., Ibarz, A., Blasco, J., Fernández‐Borràs, J., & Planas, J. V. (2013) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2013.08.005 · Cited by 54 · see citing works

Preischemic exercise reduces brain damage by ameliorating metabolic disorder in ischemia/reperfusion injury

Dornbos, D., Zwagerman, N. T., Guo, M., Ding, J. Y., Peng, C., Esmail, F., Sikharam, C., Geng, X., Guthikonda, M., & Ding, Y. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23203 · Cited by 49 · see citing works

The effect of exercise on epigenetic modifications of PGC1: The impact on type 2 diabetes

dos Santos, J. M., Tewari, S., & Benite‐Ribeiro, S. A. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.03.018 · Cited by 45 · see citing works

Oxidative stress and metabolism meet epigenetic modulation in physical exercise

García‐Giménez, J. L., Cánovas‐Cervera, I., & Pallardó, F. V. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.008 · Cited by 49 · see citing works

The Influence of Physical Activity on the Bioactive Lipids Metabolism in Obesity-Induced Muscle Insulin Resistance

Imierska, M., Kurianiuk, A., & Błachnio-Zabielska, A. U. (2020) · Biomolecules · doi:10.3390/biom10121665 · Cited by 43 · see citing works

Aqueous-Methanol Extracts of Orange-Fleshed Sweet Potato (Ipomoea batatas) Ameliorate Oxidative Stress and Modulate Type 2 Diabetes Associated Genes in Insulin Resistant C2C12 Cells

Ayeleso, T. B., Ramachela, K., & Mukwevho, E. (2018) · Molecules · doi:10.3390/molecules23082058 · Cited by 39 · see citing works

Acetylation and insulin resistance: a focus on metabolic and mitogenic cascades of insulin signaling

Emamgholipour, S., Ebrahimi, R., Bahiraee, A., Niazpour, F., & Meshkani, R. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1699498 · Cited by 37 · see citing works

Elevated levels of TWEAK in skeletal muscle promote visceral obesity, insulin resistance, and metabolic dysfunction

Sato, S., Ogura, Y., Tajrishi, M. M., & Kumar, A. (2014) · The FASEB Journal · doi:10.1096/fj.14-260703 · Cited by 34 · see citing works

Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation

Martineau, L. C. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.11.012 · Cited by 33 · see citing works

Enhancement of muscle cell glucose uptake by medicinal plant species of Canada's native populations is mediated by a common, metformin-like mechanism.

Martineau, L., Adeyiwola-Spoor, D. C. A., Vallerand, D., Afshar, A., Arnason, J., & Haddad, P. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.10.026 · Cited by 42 · see citing works

Structural constraints and the importance of lipophilicity for the mitochondrial uncoupling activity of naturally occurring caffeic acid esters with potential for the treatment of insulin resistance.

Eid, H. M., Vallerand, D., Muhammad, A., Durst, T., Haddad, P., & Martineau, L. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.08.026 · Cited by 31 · see citing works

Exercise training modalities in prediabetes: a systematic review and network meta-analysis

Zhang, H., Guo, Y., Hua, G., Guo, C., Gong, S.-M., Li, M., & Yang, Y. M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1308959 · Cited by 28 · see citing works

Feeding Tolerance, Glucose Availability, and Whole-Body Total Carbohydrate and Fat Oxidation in Male Endurance and Ultra-Endurance Runners in Response to Prolonged Exercise, Consuming a Habitual Mixed Macronutrient Diet and Carbohydrate Feeding During Exercise

Rauch, C., McCubbin, A. J., Gaskell, S. K., & Costa, R. J. S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.773054 · Cited by 29 · see citing works

Effects of regular physical exercises in the water on the metabolic profile of women with abdominal obesity

Kasprzak, Z., & Pilaczyńska-Szcześniak, Ł. (2014) · Journal of Human Kinetics · doi:10.2478/hukin-2014-0034 · Cited by 26 · see citing works

Metabolic syndrome in children and adolescents: definitions, epidemiology, pathophysiology, interventions, and challenges

Zhang, B., Shi, H., Cai, W., Yang, B., & Xiu, W. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1512642 · Cited by 24 · see citing works

Swim training attenuates oxidative damage and promotes neuroprotection in cerebral cortical slices submitted to oxygen glucose deprivation

Leite, H. R., Mourão, F. A. G., Drumond, L. E., Ferreira-Vieira, T. H., Bernardes, D., da Silva, J. F., Lemos, V. S., Moraes, M. F. D., Pereira, G. S., Carvalho‐Tavares, J., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07898.x · Cited by 22 · see citing works

Growth factors and glucose homeostasis in diabetic rats: effects of exercise training

Gomes, R. J., Leme, J. A. C. D. A., de Moura, L. P., de Araújo, M. B., Rogatto, G. P., de Moura, R. F., Luciano, E., & de Mello, M. A. R. (2009) · Cell Biochemistry and Function · doi:10.1002/cbf.1556 · Cited by 21 · see citing works

Impact of pre‐exercise feeding status on metabolic adaptations to endurance‐type exercise training

Edinburgh, R. M., Koumanov, F., & Gonzalez, J. T. (2021) · The Journal of Physiology · doi:10.1113/jp280748 · Cited by 20 · see citing works

Anti-Diabetic Activities of Jiaotaiwan in db/db Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression

Hu, N., Yuan, L., Li, H.-J., Huang, C., Mao, Q.-M., Zhang, Y., Lin, M. T., Sun, Y.-Q., Zhong, X., Tang, P., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/180721 · Cited by 19 · see citing works

Acute exercise and periodized training in different environments affect histone deacetylase activity and interleukin-10 levels in peripheral blood of patients with type 2 diabetes

Korb, A., Bertoldi, K., Lovatel, G. A., Delevatti, R. S., Elsner, V. R., de Meireles, L. C. F., Kruel, L. F. M., & Siqueira, I. R. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.04.037 · Cited by 19 · see citing works

Hypoglycemic and Hypolipogenic Action of Acetic Acid and Monascus -Fermented Grain Vinegar: A Comparative Study

Pyo, Y.-H., Lee, D.-B., Lee, Y.-W., Yoon, S.-M., & Lee, A.-R. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2021.k.0156 · Cited by 18 · see citing works

Genetic and Epigenetic Factors in Gestational Diabetes Mellitus Pathology

Ustianowski, Ł., Udzik, J., Szostak, J., Gorący, A., Ustianowska, K., & Pawlik, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316619 · Cited by 17 · see citing works

CAPE increases the expression of SOD3 through epigenetics in human retinal endothelial cells

Ohashi, A., Yasuda, H., Kamiya, T., Hara, H., & Adachi, T. (2017) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.16-109 · Cited by 16 · see citing works

Epigenetic Regulation of Obesity-Associated Type 2 Diabetes

Ibrahim, H.-I. M. (2022) · Medicina · doi:10.3390/medicina58101366 · Cited by 15 · see citing works

Molecular Mediators of the Cardiac Benefits of Exercise

Khetarpal, S. A., Li, H., Lerchenmüller, C., Rhee, J., & Rosenzweig, A. (2025) · Circulation Research · doi:10.1161/circresaha.125.325762 · Cited by 14 · see citing works

The MEF2A and MEF2D function as scaffold proteins that interact with HDAC1 or p300 in SOD3 expression in THP-1 cells

Ichihara, M., Kamiya, T., Hara, H., & Adachi, T. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1475730 · Cited by 14 · see citing works

Cigarette smoke exposure severely reduces peripheral insulin sensitivity without changing GLUT4 expression in oxidative muscle of Wistar rats

Silva, P. E., Alves, T., Fonseca, Á. T. S., Oliveira, M. A. D. N., Machado, U. F., & Seraphim, P. M. (2013) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302013000100003 · Cited by 14 · see citing works

The Glucose Transporter (GLUT4) Enhancer Factor Is Required for Normal Wing Positioning in Drosophila

Yazdani, U., Huang, Z., & Terman, J. R. (2008) · Genetics · doi:10.1534/genetics.107.078030 · Cited by 13 · see citing works

Significantly hypoglycemic effect of a novel functional bread rich in mulberry bark and improving the related functions of liver, pancreas, and kidney, on T2D mice

Weng, Y., Zhang, M., Wang, J., & Zhang, Y. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2189 · Cited by 12 · see citing works

Current epigenetic aspects the clinical kidney researcher should embrace

Witasp, A., Craenenbroeck, A. H. V., Shiels, P. G., Ekström, T. J., Stenvinkel, P., & Nordfors, L. (2017) · Clinical Science · doi:10.1042/cs20160596 · Cited by 11 · see citing works

Exercise, Diet and Sleeping as Regenerative Medicine Adjuvants: Obesity and Ageing as Illustrations

Ghanemi, A., Yoshioka, M., & St‐Amand, J. (2022) · Medicines · doi:10.3390/medicines9010007 · Cited by 11 · see citing works

Role of Epigenetics in the Pathogenesis and Management of Type 2 Diabetes Mellitus

Yahaya, T. (2019) · Translation The University of Toledo Journal of Medical Sciences · doi:10.46570/utjms.vol6-2019-319 · Cited by 10 · see citing works

N-Hydroxycinnamide Derivatives of Osthole Ameliorate Hyperglycemia through Activation of AMPK and p38 MAPK

Lee, W., Wu, H.-H., Huang, W., Li, Y.-N., Lin, R.-J., Lin, S.-Y., & Liang, Y. (2015) · Molecules · doi:10.3390/molecules20034516 · Cited by 10 · see citing works

Epigenetics of Glucose Metabolism and the Basis for T2DM Interventions

McLellan, K. C. P., Minoro, R., Sloan, L. A., & Carlos, R. (2013) · InTech eBooks · doi:10.5772/56507 · Cited by 10 · see citing works

Epigenetic regulation and heart failure

Cao, D. J. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.942285 · Cited by 10 · see citing works

Mechanisms and therapeutics of insulin signaling transduction genes in diabetic cardiomyopathy: a comprehensive updated review

He, Y., Yang, X., He, X., Wang, G., Li, C., Yuan, P., & Li, C. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1589695 · Cited by 9 · see citing works

Suppression of the GLUT4 adaptive response to exercise in fructose-fed rats

Goyaram, V., Kohn, T. A., & Ojuka, E. O. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00342.2013 · Cited by 9 · see citing works

Effects of Hypoxic Living and Training on Gene Expression in an Obese Rat Model

He, Z., Feng, L., ZHANG, L., Lu, Y., Xu, J., & Lucía, A. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182442d82 · Cited by 9 · see citing works

Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2

Ocaranza, M. P., Valderas, P., Moya, J., Gabrielli, L., Godoy, I. E., Samuel Córdova, A., Nab, P. M., Garcı́a, L., Farías, L., & Jalil, J. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01027-2 · Cited by 8 · see citing works

Mechanisms of Neuroprotection Underlying Physical Exercise in Ischemia - Reperfusion Injury

Dornbos, D., & Ding, Y. (2012) · InTech eBooks · doi:10.5772/32119 · Cited by 8 · see citing works

Melatonin induces fiber switching by improvement of mitochondrial oxidative capacity and function via NRF2/RCAN/MEF2 in the vastus lateralis muscle from both sex Zücker diabetic fatty rats

Salagre, D., Bajit, H., Fernández‐Vázquez, G., Dwairy, M., Garzón, I. J., Haro-López, R., & Agil, A. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.12.019 · Cited by 7 · see citing works

Mechanisms Involved in Glycemic Control Promoted by Exercise in Diabetics

Andrade, E. F., Silva, V. D. O., Orlando, D. R., & Pereira, L. J. (2018) · Current Diabetes Reviews · doi:10.2174/1573399814666180214144717 · Cited by 7 · see citing works

Mechanisms and clinical perspectives on imeglimin for insulin resistance in obese patients

Hou, T., Zhang, J., & Shi, W. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177937 · Cited by 6 · see citing works

Combination of Aerobic Training and Cocoa Flavanols as Effective Therapies to Reduce Metabolic and Inflammatory Disruptions in Insulin-Resistant Rats: The Exercise, Cocoa, and Diabetes Study

Melo, B. P., Zacarias, A. C., de Oliveira, J. C. C., Cordeiro, L. M. D. S., Wanner, S. P., dos Santos, M. L., de Avelar, G. F., MEEUSEN, R. R., Heyman, E., & Soares, D. D. (2021) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2021-0247 · Cited by 6 · see citing works

A functional promoter polymorphism of SLC2A4 is associated with aerobic endurance in a Chinese population

Xia, X.-H., Hu, Y., Xu, L., & Chen, T. (2014) · European Journal of Sport Science · doi:10.1080/17461391.2012.726652 · Cited by 7 · see citing works

Effects of annual training cycle on the metabolic response to supra-maximal exercise test in beach volleyball players

Pilaczyńska-Szczȩśniak, Ł., Lisiecki, D., Kasprzak, Z., Karolkiewicz, J., Śliwicka, E., Nowak, A., Podgórski, T., & Lewandowska, M. (2011) · Journal of Human Kinetics · doi:10.2478/v10078-011-0007-z · Cited by 5 · see citing works

Biochemical and functional characterization of skeletal muscle cells differentiated from tonsil‐derived mesenchymal stem cells

Choi, Y., Nam, Y. H., Jeong, S., Lee, H., Choi, S., Park, S., & Jung, S. (2023) · Muscle & Nerve · doi:10.1002/mus.27847 · Cited by 4 · see citing works

Resistin, visfatin and insulin sensitivity in selected phases of annual training cycle of triathletes

Śliwicka, E., Pilaczyńska-Szczȩśniak, Ł., Nowak, A., & Zieliński, J. (2012) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.99.2012.1.6 · Cited by 4 · see citing works

Gestational diabetes: from pathogenesis to therapeutic intervention

Zhang, X., Chi, Y., Zhang, Z., Wang, Y., Yi, F., Wang, P., Liu, Y., & Hao, W. (2026) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-026-02156-6 · Cited by 3 · see citing works

Influencia epigenómica de la actividad/inactividad física en el origen de la Diabetes mellitus tipo 2. (Epigenomic influence of the physical activity/inactivity in the origin of type 2 diabetes.)

Márques-Andrade, J. L., & Navarrete, L. A. S. (2009) · RICYDE Revista Internacional de Ciencias del Deporte · doi:10.5232/ricyde2009.01601 · Cited by 3 · see citing works

Effects of intermittent high-intensity exercise and carbohydrate supplementation on IGF-1 and glycogen of Wistar rats

Giesel, V. T., Reche, M., Pizzolato, L. S., de Araújo, L. C., Scalco, R., Corleta, H. V. E., & Capp, E. (2008) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.08.008 · Cited by 3 · see citing works

Metformina interage com o treinamento físico diminuindo a glicemia e aumentando o armazenamento de glicogênio em ratos diabéticos

Costa, E. C. D. S., Gonçalves, A. A., Brito, I. J. L., & da Silva, C. A. (2008) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922008000400003 · Cited by 3 · see citing works

AMPK regulates pupal diapause by modulating glucose metabolism in the brain of the cotton bollworm, Helicoverpa armigera

Su, Z., Jiang, S., & Xu, W. (2025) · Pest Management Science · doi:10.1002/ps.70074 · Cited by 2 · see citing works

Epigenetic landscape reveals MEF2 and SIX family-mediated transcriptional networks underlying dietary NFC/NDF ratio-induced muscle development and meat quality in Tibetan sheep

Sa, R., Zhang, F., Yang, Z., Shi, C., Hou, S., Zhang, S., & Gui, L. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1658319 · Cited by 2 · see citing works

Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus

Sun, S., Liang, S.-Z., Huang, Q., & Sun, J. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i12.112789 · Cited by 2 · see citing works

AMPK and Metabolisms of Glucose and Lipid

Chang, Y., Jiang, X., & Wang, Y. C. (2014) · Advanced materials research · doi:10.4028/www.scientific.net/amr.887-888.547 · Cited by 1 · see citing works

The Relation between Concentric and Eccentric Exercise and the Carbohydrate Metabolism in Healthy Individuals

Żebrowska, A. (2010) · Biophilia Rehabilitation Journal · doi:10.3774/brj.6.27 · Cited by 1 · see citing works

The Role of Obesity in Diabetes

Stehno‐Bittel, L. (2010) · Orthopaedic Section, APTA, Inc. eBooks · doi:10.17832/isc.2010.20.1.1 · Cited by 1 · see citing works

Role of AMPK and its possible interactions in metformin therapy and physical exercise-Research perspectives

Oliveira, L. C. D., da Silva, L. A., Wouk, J., Weber, V. M. R., Eltchechem, C. D. L., Da, C., Martins, J. C. L., Martins, F. Â. S., Malfatti, C. R. M., & Osiecki, R. (2017) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2017.71029 · Cited by 1 · see citing works

Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal Muscle

McGee, S. L., & Hargreaves, M. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1208 · Cited by 205 · see citing works

Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle. Diabetes 53: 1208–1214

Mcgee, S. L., & Hargreaves, M. (2004)

Regulation of GLUT4 Gene Expression during Exercise

Holmes, B. F., & Dohm, G. L. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000132385.34889.fe · Cited by 54 · see citing works

Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle

Antonio Zorzano, A., Palacı́n, M., & Gumà, A. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01380.x · Cited by 202 · see citing works

©2005 FASEB The FASEB Journal express article 10.1096/fj.05-4671fje. Published online December 20, 2005. Exercise increases MEF2- and GEF DNA-binding activities in human skeletal muscle

Mcgee, S. L., Sparling, D., Olson, A.-L., & Hargreaves, M. (2013)