Cited by 143Epigenetics and DNA MethylationBirth, Development, and HealthGenetic Syndromes and Imprinting

Epigenetic flexibility in metabolic regulation: disease cause and prevention

Kirchner, Henriette, Osler, Megan E., Krook, Anna, Zierath, Juleen R.·2013·Trends in Cell Biology

Abstract

Metabolic diseases, including type 2 diabetes mellitus (T2DM), are increasing worldwide at an alarming rate. Epigenetic DNA modifications such as DNA methylation and histone modifications are thought to play an important role in the development of and predisposition to metabolic diseases. This review highlights the key functions of DNA methylation and histone modifications and elucidates the underlying mechanisms of in utero programming and epigenetic inheritance, which could account for the global increase in obesity and T2DM. The impact of exercise and nutrition on the tissue-specific epigenetic profile is discussed, because these lifestyle factors may modify epigenetic programming and predisposition to obesity and T2DM.

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Crossref · 10.1016/j.tcb.2012.11.008

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  • Short-term, high-intensity exercise decreases muscle promoter methylation of genes involved in mitochondrial function such as PGC1α, TFAM, MEF2A, and PDK4, whereas in patients with T2DM these regions usually have higher methylation levels.

    “Short-term, high-intensity exercise decreases muscle promoter methylation of genes involved in mitochondrial function such as PGC1α, TFAM, MEF2A, and PDK4, whereas in patients with T2DM, these regions usually have higher methylation levels (137).”

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Authors
Kirchner, H., Osler, M. E., Krook, A., & Zierath, J. R.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Zierath, Juleen R.
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2013-05
Volume
23
Issue
5
Pages
203-209
ISSN
0962-8924 (ISSN-L)
OpenAlex
W2082220761
Cited by
143
References
69
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 10 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 15 · 2015: 19 · 2014: 19 · 2013: 7
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords
epigenetics, DNA methylation, histone modifications, metabolic disorders, type 2 diabetes, obesity, in utero programming, epigenetic inheritance, physical activity, nutrition, disease prevention
MeSH terms
Diabetes Mellitus, Type 2, Environment, Female, Fetal Growth Retardation, Histones, Humans, Life Style, Obesity, Pregnancy, Exercise, DNA Methylation, Genetic Predisposition to Disease, Maternal Nutritional Physiological Phenomena, Epigenesis, Genetic, Fetal Development

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