The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Adult‐born hippocampal neurons mature into activity‐dependent responsiveness
Abstract
The mammalian hippocampus is a highly plastic brain structure in which new neurons are generated throughout adulthood. Do these new neurons qualitatively and quantitatively participate in the activity‐dependent gene expression after challenging the hippocampus in a learning task? Adult mice were injected with bromodeoxyuridine (BrdU) to label dividing cells and indeed, individual BrdU‐labelled new neurons expressed the immediate early gene protein (IEGp) c‐fos during the acquisition phase of the Morris water maze task to the same extend as older granule cells. To assess the responsiveness of all new neurons we also analysed the expression patterns of three IEGps (c‐fos, zif268 and Homer1A) after kainic acid (KA)‐ or pentylenetetrazol (PTZ)‐induced seizures. We found that after a maturation period of between 2 and 5 weeks a comparable ratio of adult‐generated granule cells participated in IEGp‐expression as in the population of older granule cells. Thus, new neurons appear quantitatively integrated into hippocampal circuits, suggestive of a relevant contribution to hippocampal function.
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Cites
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Self-citationAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Guzowski, J. F., Lyford, G. L., Stevenson, G. D., Houston, F. P., McGaugh, J. L., Worley, P. F., & Barnes, C. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-03993.2000 · Cited by 992
Why new neurons? Possible functions for adult hippocampal neurogenesis
Kempermann, G. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00635.2002 · Cited by 469
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Cited by
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642
Self-citationNeurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072
Self-citationAdult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
Metadata
- Authors
- Jessberger, S., & Kempermann, G.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2003-11
- Volume
- 18
- Issue
- 10
- Pages
- 2707-2712
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2001344057
- Cited by
- 330
- References
- 7
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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