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α-Tocopherol Protects Against Oxidative Stress in the Fragile X Knockout Mouse: an Experimental Therapeutic Approach for the Fmr1 Deficiency

de Diego-Otero, Y., Romero-Zerbo, Y., Bekay, R. E., Decara, J., Sanchez, L., Fonseca, F. R.-D., & Arco-Herrera, I. D. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.152 · Cited by 133 · see citing works

A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model

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The multifaceted role of mitochondria in autism spectrum disorder

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Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice

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Fragile X Syndrome: from molecular pathology to therapy

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Fragile X Syndrome and Targeted Treatment Trials

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Fragile X syndrome: A review of clinical management

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Glutathione peroxidases as oncotargets

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Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology

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Photoactivation of ROS Production In Situ Transiently Activates Cell Proliferation in Mouse Skin and in the Hair Follicle Stem Cell Niche Promoting Hair Growth and Wound Healing

Carrasco, E., Calvo-Sánchez, M. I., Blázquez‐Castro, A., Vecchio, D., Zamarrón, A., de Almeida, I. J. D., STOCKERT, J. C., Hamblin, M. R., Juarranz, Á., & Espada, J. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.248 · Cited by 82 · see citing works

Brief Report: Acamprosate in Fragile X Syndrome

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The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules

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Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders

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The Familial Co-Aggregation of Attention-Deficit/Hyperactivity Disorder and Intellectual Disability: A Register-Based Family Study

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Treatment of the psychiatric problems associated with fragile X syndrome

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The potential role of melatonin on sleep deprivation-induced cognitive impairments: Implication of FMRP on cognitive function

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Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome

Romero‐Zerbo, S., Decara, J. M., Bekay, R. E., Salido, L. S., del Arco, I., de Fonseca, F. R., & de Diego‐Otero, Y. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00653.x · Cited by 44 · see citing works

The Fragile X Protein and Genome Function

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Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome

D’Antoni, S., Lidia de, B. A. R. I., Valenti, D., Borro, M., Bonaccorso, C. M., Simmaco, M., Vacca, R. A., & Catania, M. V. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0221 · Cited by 40 · see citing works

Repurposing available drugs for neurodevelopmental disorders: The fragile X experience

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Gallic acid loaded disulfide cross-linked biocompatible polymeric nanogels as controlled release system: synthesis, characterization, and antioxidant activity

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Melatonin as a Novel Interventional Candidate for Fragile X Syndrome with Autism Spectrum Disorder in Humans

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Quantitative Phosphoproteomics of MurineFmr1-KO Cell Lines Provides New Insights into FMRP-Dependent Signal Transduction Mechanisms

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Sleep deficiency as a driver of cellular stress and damage in neurological disorders

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Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement

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Switching on a transient endogenous ROS production in mammalian cells and tissues

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Imbalance between Glutamate and GABA in Fmr1 Knockout Astrocytes Influences Neuronal Development

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Synthesis, Characterization, and Evaluation of Radical Scavenging Ability of Ellagic Acid-Loaded Nanogels

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Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability

Bosshard, M., Aprigliano, R., Gattiker, C., Palibrk, V., Markkanen, E., Backe, P. H., Pellegrino, S., Raymond, F. L., Froyen, G., Altmeyer, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15380-y · Cited by 25 · see citing works

Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer

Maurin, T., & Bardoni, B. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00113 · Cited by 25 · see citing works

An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability

Lima‐Cabello, E., García-Guirado, F., Medina, R. C., Bekay, R. E., Pérez-Costillas, L., Quintero-Navarro, C., Salido, L. S., & de Diego‐Otero, Y. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8548910 · Cited by 25 · see citing works

The RNA-binding fragile-X mental retardation protein and its role beyond the brain

Malecki, C., Hambly, B. D., Jeremy, R., & Robertson, E. (2020) · Biophysical Reviews · doi:10.1007/s12551-020-00730-4 · Cited by 24 · see citing works

Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model

Vandenberg, G. G., Dawson, N. J., Head, A., Scott, G. R., & Scott, A. L. M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105036 · Cited by 23 · see citing works

Fragile X syndrome: An aging perspective

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How Robust is the Evidence for a Role of Oxidative Stress in Autism Spectrum Disorders and Intellectual Disabilities?

Burke, S. L., Cobb, J., Agarwal, R., Maddux, M., & Cooke, M. S. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04611-3 · Cited by 22 · see citing works

Rett Syndrome and Fragile X Syndrome: Different Etiology With Common Molecular Dysfunctions

Bach, S., Shovlin, S., Moriarty, M. J., Bardoni, B., & Tropea, D. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.764761 · Cited by 23 · see citing works

Depletion of Mitochondrial Components from Extracellular Vesicles Secreted from Astrocytes in a Mouse Model of Fragile X Syndrome

Ha, B. G., Heo, J.-Y., Jang, Y.-J., Park, T., Choi, J., Jang, W. Y., & Jeong, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010410 · Cited by 21 · see citing works

Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila

Monzo, K., Dowd, S. R., Minden, J. S., & Sisson, J. C. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.01.028 · Cited by 20 · see citing works

Programmed Cell Death Is Impaired in the Developing Brain of Fmr1 Mutants

Cheng, Y., Corbin, J. G., & Levy, R. J. (2013) · Developmental Neuroscience · doi:10.1159/000353248 · Cited by 13 · see citing works

An association study of severity of intellectual disability with peripheral biomarkers of disabled children in a rehabilitation home, Kolkata, India

Sengupta, A., Das, U. B., Manna, K., Biswas, S., Datta, S., Khan, A., Bhattacharya, T., Saha, S., Mitra, T., Mukherjee, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49728-3 · Cited by 14 · see citing works

Phenotypic changes in calbindin D28K immunoreactivity in the hippocampus of Fmr1 knockout mice

Real, M. A., Simón-Extremera, P., Heredia, R., de Diego‐Otero, Y., & Guirado, S. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22643 · Cited by 14 · see citing works

Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins

Bardoni, B., Abekhoukh, S., Zongaro, S., & Melko, M. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00003-0 · Cited by 13 · see citing works

A combination of ascorbic acid and α-tocopherol to test the effectiveness and safety in the fragile X syndrome: study protocol for a phase II, randomized, placebo-controlled trial

de Diego‐Otero, Y., Medina, R. C., Quintero-Navarro, C., Salido, L. S., García-Guirado, F., del Arco, I., Fernández-Carvajal, I., Ferrando-Lucas, T., Caballero‐Andaluz, R., & Pérez-Costillas, L. (2014) · Trials · doi:10.1186/1745-6215-15-345 · Cited by 13 · see citing works

Translational modulator ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Coulson, R. L., Frattini, V., Moyer, C. E., Hodges, J., Walter, P., Mourrain, P., Zuo, Y., & Wang, G. X. (2024) · iScience · doi:10.1016/j.isci.2024.109259 · Cited by 11 · see citing works

Proteomics insights into fragile X syndrome: Unraveling molecular mechanisms and therapeutic avenues

Abbasi, D. A., Berry‐Kravis, E., Zhao, X., & Cologna, S. M. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106486 · Cited by 12 · see citing works

Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes

Marco, B. D., Dell’Albani, P., D’Antoni, S., Spatuzza, M., Bonaccorso, C. M., Musumeci, S. A., Drago, F., Bardoni, B., & Catania, M. V. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105338 · Cited by 12 · see citing works

Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects

Vandenberg, G. G., Thotakura, A., & Scott, A. L. M. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00130.2021 · Cited by 11 · see citing works

Mitochondrial dysfunction in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome: prospect use of antioxidants and mitochondrial nutrients

Pagano, G., Lyakhovich, A., Pallardó, F. V., Tiano, L., Zatterale, A., & Trifuoggi, M. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09415-7 · Cited by 10 · see citing works

Role of fragile X messenger ribonucleoprotein 1 in the pathophysiology of brain disorders: a glia perspective

D’Antoni, S., Spatuzza, M., Bonaccorso, C. M., & Catania, M. V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105731 · Cited by 10 · see citing works

Increased iron content in the heart of the Fmr1 knockout mouse

Talvio, K., Kanninen, K. M., White, A. R., Koıstınaho, J., & Castrén, M. L. (2021) · BioMetals · doi:10.1007/s10534-021-00320-1 · Cited by 10 · see citing works

Molecular Pathogenesis and Peripheral Monitoring of Adult Fragile X-Associated Syndromes

Valor, L. M., Morales, J. C., Hervás-Corpión, I., & Marín, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168368 · Cited by 10 · see citing works

Astrocytes in fragile X syndrome

Talvio, K., & Castrén, M. L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1322541 · Cited by 8 · see citing works

Oxidative Stress and Protein Oxidation

Grune, T., Catalgol, B., & Jung, T. (2012) · Wiley eBooks · doi:10.1002/9781118493038.ch1 · Cited by 7 · see citing works

A novel combination treatment for fragile X syndrome predicted using computational methods

Chadwick, W., Angulo-Herrera, I., Cogram, P., Deacon, R. J. M., Mason, D. J., Brown, D., Roberts, I., O’Donovan, D. J., Tranfaglia, M. R., Guilliams, T., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad353 · Cited by 6 · see citing works

The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes

Cogram, P., Fernández-Beltrán, L. C., Casarejos, M. J., Sánchez-Yepes, S., Rodríguez‐Martín, E., García‐Rubia, A., Sánchez-Barrena, M. J., Gil, C., Martı́nez, A., & Mansilla, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1007531 · Cited by 5 · see citing works

Review of Salient Investigational Drugs for the Treatment of Fragile X Syndrome

Munshi, K. R., Pawlowski, K. G., Gonzalez–Heydrich, J., & Picker, J. D. (2017) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2016.0200 · Cited by 5 · see citing works

Neuroinflammation links COVID-19 and fragile X syndrome: Role of MMP-9, IGF-1, IL-10, metformin, statins and curcuminPreprint

Altable, M. (2021) · doi:10.32388/ko4c77 · Cited by 3 · see citing works

Apocynin, a Selective NADPH Oxidase (Nox2) Inhibitor, Ameliorates Behavioural and Learning Deficits in the Fragile X Syndrome Mouse Model

de Diego‐Otero, Y., Bekay, R. E., García-Guirado, F., Salido, L. S., & Giráldez‐Pérez, R. M. (2024) · Biomedicines · doi:10.3390/biomedicines12122887 · Cited by 4 · see citing works

Neuroinflammation links COVID-19 and fragile X syndrome: Role of MMP-9, IGF-1, IL-10, metformin, statins and curcuminPreprint

Altable, M., & de la Serna, J. M. (2021) · doi:10.32388/ko4c77.2 · Cited by 3 · see citing works

Intersection of the fragile X-related disorders and the DNA damage response

Kumari, D., Grant-Bier, J., Kadyrov, F. A., & Usdin, K. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103785 · Cited by 2 · see citing works

An Altered Gut Microbiota–Brain Axis in Fragile X Syndrome May Explain Autistic Traits in Some Patients

de Diego‐Otero, Y., Bodoque-García, A., Quintero-Navarro, C., Medina, R. C., & Salgado-Cacho, J. M. (2025) · Psychiatry International · doi:10.3390/psychiatryint6030107 · Cited by 2 · see citing works

Therapeutic approaches for the future treatment of Fragile X

Sastre, A., Campillo, N. E., Gil, C., & Martı́nez, A. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.01.003 · Cited by 2 · see citing works

Linking the fragile X mental retardation protein to the lipoxygenase pathway

Beaulieu, M.-A. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2012.11.046 · Cited by 2 · see citing works

FMR protein: Evidence of an emerging role in retinal aging?

Ardourel, M., Ranchon‐Cole, I., Pâris, A., Felgerolle, C., Acar, N., Lesne, F., Briault, S., & Perche, O. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109282 · Cited by 2 · see citing works

Pigment epithelium‐derived factor ( PEDF ) and PEDF‐receptor in the adult mouse brain: Differential spatial/temporal localization pattern

de Diego‐Otero, Y., Giráldez‐Pérez, R. M., Lima‐Cabello, E., Heredia‐Farfan, R., Medina, R. C., Salido, L. S., & Pérez-Costillas, L. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24940 · Cited by 2 · see citing works

Oxidative Stress and Dietary Interventions in Autism: Exploring the Role of Zinc, Antioxidant Enzymes and Other Micronutrients in the Neurobiology of Autism

Castrén, M. L., Westermarck, T., & Atroshi, F. (2014) · InTech eBooks · doi:10.5772/57512 · Cited by 1 · see citing works

Fragile X Syndrome: From Pathophysiology to New Therapeutic Perspectives

D’Antoni, S., Spatuzza, M., Carmela, M., Aloisi, E., Musumeci, S. A., & Vincenza, M. (2012) · InTech eBooks · doi:10.5772/31387

Oral Ascorbic Acid and Alpha-Tocopherol to Reduce Behavioural Problems in Young Patients Affected of Fragile X Syndrome: A Randomized, Double-Blind, Placebo-Controlled Phase II Pilot Trial

de Diego‐Otero, Y., Quintero-Navarro, C., Medina, R. C., Heredia‐Farfan, R., Salido, L. S., Lima‐Cabello, E., Higuero-Tapiador, A., Del, I., Fernández-Carvajal, I., Ferrando-Lucas, T., et al. (2012) · InTech eBooks · doi:10.5772/29480

Avances en investigación de la discapacidad intelectual de origen genético: tratamientos experimentales en el síndrome X frágil

de Diego‐Otero, Y., Pérez-Costillas, L., Medina, R. C., Quintero-Navarro, C., Benítez, I. D. P., Casado, Y., & Cobas, C. N. (2017) · Revista Española de Discapacidad · doi:10.5569/2340-5104.05.01.12

The Fragile X Mental Retardation Protein protects the lung from xenobiotic stress by facilitating the Integrated Stress ResponsePreprint

Basu, D. S., Bhavsar, R., Gulami, I., Lingamallu, S. M., Muddashetty, R. S., Veeranna, C., Chattarji, S., Thimmulappa, R. K., Bhattacharya, A., & Guha, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.16.435743

Sleep in children with genetic disorders

Licis, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00224-3

Assessment of Antioxidants Biomarkers in Plasma of Fragile X Syndrome Patients

Samir, R. M., Amer, N. N., Ali, O. S. M., Meguid, N. A., Hashish, A. F., & Salem, S. I. (2022) · Azhar International Journal of Pharmaceutical and Medical Sciences/Azhar International Journal of Pharmaceutical and Medical Sciences · doi:10.21608/aijpms.2022.93451.1088

Faculty Opinions recommendation of Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.

Hollander, E., & Uzunova, G. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735074921.793558241

Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndromePreprint

Coulson, R. L., Frattini, V., Moyer, C. E., Hodges, J., Walter, P., Mourrain, P., Zuo, Y., & Wang, G. X. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.08.553269

Involvement of mGluR5/Homer crosstalk disruption in the pathophysiology of Fragile X Syndrome

Aloisi, E. (2015) · theses.fr (ABES) · doi:10.70675/e628d840zb6adz4e63z9d1fz71559b23fe24

Aberrant astrocyte signalling during hippocampal development in the Fmr1-knockout mouse model

Napier, M., Monneypenny, A., MacDonald, J., & Scott, A. (2026) · Glial health research. · doi:10.1016/j.ghres.2026.100021

Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome

Romero‐Zerbo, S., Decara, J. M., Bekay, R. E., Salido, L. S., del Arco, I., de Fonseca, F. R., & de Diego‐Otero, Y. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00653.x · Cited by 44 · see citing works

An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability

Lima‐Cabello, E., García-Guirado, F., Medina, R. C., Bekay, R. E., Pérez-Costillas, L., Quintero-Navarro, C., Salido, L. S., & de Diego‐Otero, Y. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8548910 · Cited by 25 · see citing works

α-Tocopherol Protects Against Oxidative Stress in the Fragile X Knockout Mouse: an Experimental Therapeutic Approach for the Fmr1 Deficiency

de Diego-Otero, Y., Romero-Zerbo, Y., Bekay, R. E., Decara, J., Sanchez, L., Fonseca, F. R.-D., & Arco-Herrera, I. D. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.152 · Cited by 133 · see citing works

Astrocytic Deficits in Maintaining Oxidative Homeostasis in the Fragile X Syndrome Cortex

Vandenberg, G. G. (2020) · MacSphere (McMaster University) · doi:10.71548/18670

Research Article An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability

Lima‐Cabello, E., García-Guirado, F., Medina, R. C., Bekay, R. E., Perez-costillas, L., Quintero-Navarro, C., Salido, L. S., & Diego-otero, A. D. (2016)