Activation pattern of the limbic system following spatial learning under stress
Open accessAbstract
Anatomical evidence suggests an interplay between the dorsal CA1 of the hippocampus (CA1), the basolateral amygdala (BLA) and the entorhinal cortex (EC), but their specific interactions in the context of emotional memory remain obscure. Here, we sought to elucidate the activation pattern in these areas following spatial learning under different stress conditions in the Morris water maze, using cAMP response element‐binding protein (CREB) activation as a marker. Stress levels were manipulated by maintaining the water maze at one of two different temperatures: lower stress (warm water) or higher stress (cold water). Three groups of animals were tested under each condition: a Learning group, trained in the water maze with a hidden escape platform; a No‐Platform group, subjected to the maze without an escape platform; and a Naïve group. To evaluate the quality of the spatial memory formed, we also tested long‐term memory retention of the initial location of the platform following an interference procedure (reversal training). In the CA1 and EC, we found different CREB activation patterns for the lower‐ and higher‐stress groups. By contrast, in the BLA a similar pattern of activation was detected under both stress levels. The data reveal a difference in the sensitivity of the memory to interference, with reversal training interference affecting the memory of the initial platform location only under the higher‐stress condition. The results suggest that stress‐dependent alterations in limbic system activation patterns underlie differences in the quality of the memory formed.
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Previous animal studies have shown that stress can alter relative activation patterns within the limbic system.
“Previous animal studies have shown that stress can alter relative activation patterns within the limbic system,122”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [122]
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- Authors
- Kogan, I., & Richter‐Levin, G.
- Affiliations
- University of Haifa (IL)
- Corresponding author
- Richter‐Levin, Gal
- ORCID
- Richter‐Levin, Gal
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-02
- Volume
- 27
- Issue
- 3
- Pages
- 715-722
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2015644952
- Cited by
- 34
- References
- 54
- Citations by year
- 2024: 1 · 2023: 2 · 2020: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 5
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Charles H. Revson Foundation
- Israel Science Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- limbic system, spatial learning, stress, hippocampal CA1, basolateral amygdala, entorhinal cortex, CREB activation, emotional memory, memory interference, reversal learning, water temperature stress, memory quality
- MeSH terms
- Amygdala, Animals, Avoidance Learning, Cold Temperature, Emotions, Hippocampus, Learning, Limbic System, Male, Memory Disorders, Neural Pathways, Neuropsychological Tests, Orientation, Space Perception, Stress, Psychological, Biomarkers, Rats, Wistar, Cyclic AMP Response Element-Binding Protein, Entorhinal Cortex, Maze Learning, Rats
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