Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre‐exposure
Open accessAbstract
Stressors can exert a wide variety of responses, ranging from adaptive responses to pathological changes; moreover, recent studies suggest that mild stressors can attenuate the response of a system to major stressful events. We have previously shown that 2‐week exposure to cold, a comparatively mild inescapable stressor, induced a pronounced reduction in ventral tegmental area (VTA) dopamine (DA) neuron activity, whereas restraint stress increases DA neuron activity. However, it is not known if these stressors differentially impact the VTA in a region‐specific manner, if they differentially impact behavioral responses, or whether the effects of such different stressors are additive or antagonistic with regard to their impact on DA neuron firing. To address these questions, single‐unit extracellular recordings were performed in anesthetized control rats and rats exposed to chronic cold, and tested after delivery of a 2‐h restraint session. Chronic cold stress strongly attenuated the number of DA neurons firing in the VTA, and this effect occurred primarily in the medial and central VTA regions that preferentially project to reward‐related ventral striatal regions. Chronic cold exposure also prevented the pronounced increase in DA neuron population activity without affecting the behavioral sensitization to amphetamine produced by restraint stress. Taken together, these data show that a prolonged inescapable mild stressor can induce plastic changes that attenuate the DA system response to acute stress.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic mild or chronic cold stress reduce ventral tegmental area population activity.
“chronic mild or chronic cold stress instead reduce VTA population activity [50, 51].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Kalivas, P. W., & Stewart, J. (1991) · Brain Research Reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,021 · see citing works
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758 · see citing works
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543 · see citing works
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Intrinsic firing patterns of diverse neocortical neurons
Connors, B. W., & Gutnick, M. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90185-d · Cited by 1,440 · see citing works
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106 · see citing works
Self-citationAbercrombie, E. D., Keefe, K. A., DiFrischia, D. S., & Zigmond, M. J. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09224.x · Cited by 1,106 · see citing works
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034 · see citing works
Self-citationGrace, A. A., & Bunney, B. S. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90135-5 · Cited by 937 · see citing works
Self-citationStressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926 · see citing works
Barthó, P., Hirase, H., Monconduit, L., Zugaro, M. B., Harris, K. D., & Buzsáki, G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01170.2003 · Cited by 888 · see citing works
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02866.1984 · Cited by 862 · see citing works
Self-citationPsychopharmacology: The Fourth Generation of Progress
Kramlinger, K. G. (1995) · Mayo Clinic Proceedings · doi:10.4065/70.10.1021-a · Cited by 779 · see citing works
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli
Lammel, S., Ion, D. I., Roeper, J., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.025 · Cited by 766 · see citing works
The role of stress in drug self-administration
Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674 · see citing works
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655 · see citing works
Corticosteroids in relation to fear, anxiety and psychopathology
Korte, S. M. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00002-1 · Cited by 607 · see citing works
Role of brain norepinephrine in the behavioral response to stress
Morilak, D. A., Barrera, G., Echevarria, D. J., Garcia, A. S., Hernandez, A., Ma, S., & Petre, C. O. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.007 · Cited by 570 · see citing works
Interchangeability of Stress and Amphetamine in Sensitization
Antelman, S. M., Eichler, A. J., Black, C. A., & Kocan, D. J. (1980) · Science · doi:10.1126/science.7188649 · Cited by 562 · see citing works
Floresco, S., Todd, C. L., & Grace, A. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04915.2001 · Cited by 556 · see citing works
Self-citationBhatnagar, S., & Dallman, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00577-0 · Cited by 511 · see citing works
Firing modes of midbrain dopamine cells in the freely moving rat
Hyland, B. I., Reynolds, J. N. J., HAY, J. G., Perk, C. G., & Miller, R. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00267-1 · Cited by 487 · see citing works
Mizoguchi, K., Yuzurihara, M., Ishige, A., Sasaki, H., Chui, D.-H., & Tabira, T. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01568.2000 · Cited by 481 · see citing works
Finlay, J. M., Zigmond, M. J., & Abercrombie, E. D. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00331-x · Cited by 434 · see citing works
Chapter 19 The determinants of stress-induced activation of the prefrontal cortical dopamine system
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62691-6 · Cited by 364 · see citing works
Selye, H. (1956) · PubMed · Cited by 341 · see citing works
The mesoaccumbens dopamine in coping with stress
Cabib, S., & Puglisi-Allegra, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.012 · Cited by 329 · see citing works
Květňanský, R., Weise, V. K., & Kopin, I. J. (1970) · Endocrinology · doi:10.1210/endo-87-4-744 · Cited by 317 · see citing works
Comparative analysis of ACTH and corticosterone sampling methods in rats
Vahl, T. P., Ulrich-Lai, Y. M., Ostrander, M. M., Dolgas, C. M., Elfers, E. E., Seeley, R. J., D'Alessio, D. A., & Herman, J. P. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00122.2005 · Cited by 304 · see citing works
Deutch, A. Y., Clark, W. A., & Roth, R. H. (1990) · Brain Research · doi:10.1016/0006-8993(90)91557-w · Cited by 302 · see citing works
Criteria for rationally evaluating animal models of postraumatic stress disorder
Yehuda, R., & Antelman, S. M. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90001-t · Cited by 301 · see citing works
Lodge, D. J., & Grace, A. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300963 · Cited by 280 · see citing works
Self-citationHenry, D. J., Greene, M. A., & White, F. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21086-2 · Cited by 268 · see citing works
Floresco, S., Blaha, C. D., Yang, C. R., & Phillips, A. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02851.2001 · Cited by 242 · see citing works
Laviolette, S. R., Lipski, W. J., & Grace, A. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1168-05.2005 · Cited by 235 · see citing works
Self-citationAcute stress induces time-dependent responses in dopamine mesolimbic system
Puglisi‐Allegra, S., Impérato, A., Angelucci, L., & Cabib, S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90192-x · Cited by 213 · see citing works
Baeg, E. H. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.5.441 · Cited by 205 · see citing works
White, F. J., & Wang, R. Y. (1984) · Brain Research · doi:10.1016/0006-8993(84)90594-8 · Cited by 190 · see citing works
Hauger, R. L., Lorang, M. T., Irwin, M. R., & Aguilera, G. (1990) · Brain Research · doi:10.1016/0006-8993(90)91738-3 · Cited by 189 · see citing works
Gresch, P. J., Sved, A. F., Zigmond, M. J., & Finlay, J. M. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63020575.x · Cited by 179 · see citing works
Jedema, H. P., & Grace, A. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2830-04.2004 · Cited by 176 · see citing works
Self-citationThe Effects of Stress on Central Dopaminergic Neurons: Possible Clinical Implications
Finlay, J. M., & Zigmond, M. J. (1997) · Neurochemical Research · doi:10.1023/a:1022075324164 · Cited by 174 · see citing works
Valenti, O., Lodge, D. J., & Grace, A. A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5310-10.2011 · Cited by 173 · see citing works
Self-citationBiochemical Adaptations in the Mesolimbic Dopamine System in Response to Repeated Stress
Ortiz, J. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00152-4 · Cited by 170 · see citing works
Buffalari, D., & Grace, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2007-07.2007 · Cited by 157 · see citing works
Self-citationAmat, J., Paul, E., Watkins, L. R., & Maier, S. F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.005 · Cited by 153 · see citing works
Response of anterior pituitary hormones to chronic stress. The specificity of adaptation
Armario, A., López‐Calderón, A., Jolín, T., & Balasch, J. (1986) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(86)90011-4 · Cited by 150 · see citing works
Textbook of environmental physiology
Folk, G. E. (1974) · Cited by 144 · see citing works
Prevention of denervation atrophy in muscle: Mammalian neurotrophic factor is not transferrin
Davis, H. L., & Heinicke, E. (1984) · Brain Research · doi:10.1016/0006-8993(84)90595-x · Cited by 144 · see citing works
DRONJAK, S., GAVRILOVI, L., FILIPOVI, D., & RADOJI, M. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.01.011 · Cited by 142 · see citing works
Restraint-induced hypoactivity in an elevated plus-maze
Padovan, C. M., & Guimarães, F. S. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000000100011 · Cited by 133 · see citing works
Chronic Cold Stress Reduces the Spontaneous Activity of Ventral Tegmental Dopamine Neurons
Moore, H. M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00188-3 · Cited by 130 · see citing works
Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats
Kompagne, H., Bárdos, G., Szénási, G., Gacsályi, I., Hársing, L. G., & Lévay, G. I. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.008 · Cited by 129 · see citing works
Lodge, D. J., & Grace, A. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1582-08.2008 · Cited by 127 · see citing works
Self-citationMa, S., & Morilak, D. A. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01279.x · Cited by 111 · see citing works
Transituational immunization and therapy of learned helplessness in the rat.
Williams, J. L., & Maier, S. F. (1977) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.3.3.240 · Cited by 101 · see citing works
Pardon, M., Ma, S., & Morilak, D. A. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02355-2 · Cited by 97 · see citing works
Ma, S., & Morilak, D. A. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01372.x · Cited by 94 · see citing works
McMahon, A., Kvetňansk, R., Fukuhara, K., Weise, V. K., Kopin, I. J., & Sabban, E. L. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10954.x · Cited by 90 · see citing works
Belda, X., Fuentes, S., Nadal, R. A., & Armario, A. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.07.003 · Cited by 85 · see citing works
Cabib, S., & Puglisi‐Allegra, S. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00750-6 · Cited by 73 · see citing works
Kvetňansk, R., Goldstein, D. S., Weise, V. K., Holmes, C. S., Szemeredi, K., Bagdy, G., & Kopin, I. J. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10977.x · Cited by 73 · see citing works
Fine Topography of Brain Areas Activated by Cold Stress
Baffi, J., & Palkovits, M. (2000) · Neuroendocrinology · doi:10.1159/000054577 · Cited by 67 · see citing works
Mana, M. J., & Grace, A. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00225-x · Cited by 66 · see citing works
Self-citationJedema, H. P., Sved, A. F., Zigmond, M. J., & Finlay, J. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01369-4 · Cited by 65 · see citing works
Jedema, H., & Grace, A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300020 · Cited by 61 · see citing works
Self-citationBhatnagar, S., Dallman, M. F., Roderick, R. E., Basbaum, A. I., & Taylor, B. K. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00382-5 · Cited by 60 · see citing works
Bhatnagar, S., Mitchell, J. B., Betito, K., Boksa, P., & Meaney, M. J. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00161-8 · Cited by 59 · see citing works
Carlson, J. N., Visker, K. E., Keller, R. W., & Glick, S. D. (1996) · Brain Research · doi:10.1016/0006-8993(95)01290-7 · Cited by 58 · see citing works
Fluharty, S. J., Snyder, G. L., Zigmond, M. J., & Stricker, E. M. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21117-x · Cited by 58 · see citing works
Lodge, D. J., & Grace, A. A. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000113 · Cited by 52 · see citing works
Self-citationThe Significance of the Adrenals for Adaptation
Selye, H. (1937) · Science · doi:10.1126/science.85.2201.247 · Cited by 44 · see citing works
Valenti, O., & Grace, A. A. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990599 · Cited by 44 · see citing works
Self-citationPacchioni, A. M., Cador, M., Bregonzio, C., & Cancela, L. M. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301080 · Cited by 41 · see citing works
Thermal homeostasis in rats after intrahypothalamic injections of 6-hyroxydopamine
Zoeren, J. V., & Stricker, E. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.4.932 · Cited by 39 · see citing works
Braszko, J. J., Bannon, M. J., Bunney, B. S., & Roth, R. H. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32416-x · Cited by 37 · see citing works
NORADRENALINE RELEASE IN RATS DURING PROLONGED COLD‐STRESS AND REPEATED SWIM‐STRESS
BENEDICT, C. R., Fillenz, M., & Stanford, S. C. (1979) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1979.tb13689.x · Cited by 34 · see citing works
Valenti, O., & Grace, A. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn114 · Cited by 21 · see citing works
Self-citationEliasson, K. (2009) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1984.tb04994.x · Cited by 18 · see citing works
Flagged first, then by citations
1 of the 83 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Willner P Bloom FE Kupfer DJ 1995 Dopamine mechanisms in depression and mania Psychopharmacology: The Fourth Generation of Progress Raven Press New York 921 932
Cited by
Sorted by citations
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression
Grace, A. A. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.57 · Cited by 1,166 · see citing works
Self-citationRapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., et al. (2013) · Nature · doi:10.1038/nature11740 · Cited by 1,073 · see citing works
The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia
Howes, O. D., McCutcheon, R. A., Owen, M. J., & Murray, R. M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.014 · Cited by 604 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265 · see citing works
Amygdala-Ventral Pallidum Pathway Decreases Dopamine Activity After Chronic Mild Stress in Rats
Chang, C.-H., & Grace, A. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.020 · Cited by 239 · see citing works
Self-citationReinforcement learning in depression: a review of computational research
Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., & Kusumi, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.005 · Cited by 233 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 226 · see citing works
Belujon, P., & Grace, A. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.014 · Cited by 225 · see citing works
Self-citationChen, C., Nakagawa, S., An, Y., Ito, K., Kitaichi, Y., & Kusumi, I. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.001 · Cited by 191 · see citing works
Regulation of dopamine system responsivity and its adaptive and pathological response to stress
Belujon, P., & Grace, A. A. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.2516 · Cited by 185 · see citing works
Self-citationNeural Substrates of Depression and Resilience
Han, M., & Nestler, E. J. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0527-x · Cited by 178 · see citing works
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Friedman, A. K., Juarez, B., Ku, S. M., Zhang, H., Calizo, R. C., Walsh, J. J., Chaudhury, D., Zhang, S., Hawkins, A., Dietz, D. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms11671 · Cited by 172 · see citing works
The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder
Abdallah, C. G., Averill, L. A., Akiki, T. J., Raza, M., Averill, C. L., Gomaa, H., Adikey, A., & Krystal, J. H. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021701 · Cited by 171 · see citing works
Neuronal Correlates of Depression
Chaudhury, D., Liu, H., & Han, M.-H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 139 · see citing works
Dysregulation of Midbrain Dopamine System and the Pathophysiology of Schizophrenia
Sonnenschein, S. F., Gomes, F. V., & Grace, A. A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00613 · Cited by 132 · see citing works
Self-citationStress effects on the neural substrates of motivated behavior
Hollon, N. G., Burgeno, L. M., & Phillips, P. E. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4114 · Cited by 118 · see citing works
In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens
Muir, J., Lorsch, Z. S., Ramakrishnan, C., Deisseroth, K., Nestler, E. J., Calipari, E. S., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.122 · Cited by 116 · see citing works
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112 · see citing works
Brain mechanisms mediating effects of stress on reward sensitivity
Ironside, M., Kumar, P., Kang, M. S., & Pizzagalli, D. A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.016 · Cited by 110 · see citing works
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works
Patton, M. H., Bizup, B. T., & Grace, A. A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2449-13.2013 · Cited by 94 · see citing works
Self-citationRincón-Cortés, M., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx048 · Cited by 98 · see citing works
Self-citationOptogenetic insights into striatal function and behavior
Lenz, J. D., & Lobo, M. K. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.018 · Cited by 93 · see citing works
Moreines, J. L., Owrutsky, Z. L., & Grace, A. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.249 · Cited by 93 · see citing works
Self-citationMuir, J., Lopez, J., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0291-6 · Cited by 92 · see citing works
Liu, D., Tang, Q., Cui, Y., Song, Y., Liu, Y., Yang, J., Liu, H., Zhang, Y., Wu, S., Song, Y., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001083 · Cited by 79 · see citing works
Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J. C., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. J., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0102-9 · Cited by 77 · see citing works
Gill, K. M., Cook, J. M., Poe, M. M., & Grace, A. A. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt236 · Cited by 73 · see citing works
Self-citationBiselli, T., Lange, S. S., Sablottny, L., Steffen, J., & Walther, A. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14603 · Cited by 72 · see citing works
Rincón‐Cortés, M., & Grace, A. A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112367 · Cited by 71 · see citing works
Self-citationZhang, S., Zhang, H., Ku, S. M., Juarez, B., Morel, C., Tzavaras, N., Montgomery, S. E., Hodes, G. E., Brancato, A., Russo, S. J., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.021 · Cited by 71 · see citing works
Radwan, B., Liu, H., & Chaudhury, D. (2018) · Brain Research · doi:10.1016/j.brainres.2018.11.031 · Cited by 72 · see citing works
Uban, K. A., Comeau, W. L., Ellis, L. A., Galea, L. A. M., & Weinberg, J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.017 · Cited by 59 · see citing works
Fenoy, A. J., Quevedo, J., & Soares, J. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01100-6 · Cited by 57 · see citing works
Neurobiology of bruxism: The impact of stress (Review)
Pavlou, I., Spandidos, D. A., Zoumpourlis, V., & Papakosta, V. (2024) · Biomedical Reports · doi:10.3892/br.2024.1747 · Cited by 55 · see citing works
Sakurai, T., & Gamo, N. J. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.11.007 · Cited by 49 · see citing works
Zhao, X., Seese, R. R., Yun, K., Peng, T., & Wang, Z. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.046 · Cited by 50 · see citing works
Stelly, C. E., Pomrenze, M. B., Cook, J. B., & Morikawa, H. (2016) · eLife · doi:10.7554/elife.15448 · Cited by 49 · see citing works
Ventral tegmental area subcircuits process rewarding and aversive experiences
Bariselli, S., Glangetas, C., Tzanoulinou, S., & Bellone, C. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13779 · Cited by 51 · see citing works
Retinoic acid and depressive disorders: Evidence and possible neurobiological mechanisms
Hu, P., van Dam, A., Wang, Y., Lucassen, P. J., & Zhou, J.-N. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.013 · Cited by 47 · see citing works
Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test
Addy, N. A., Nunes, E. J., & Wickham, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.002 · Cited by 42 · see citing works
Bonapersona, V., Joëls, M., & Sarabdjitsingh, R. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.003 · Cited by 42 · see citing works
Fang, X., Chen, Y., Wang, J., Zhang, Z., Bai, Y., Denney, K., Gan, L., Guo, M., Weintraub, N. L., Lei, Y., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01872-5 · Cited by 37 · see citing works
Rincón‐Cortés, M., & Grace, A. A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01210-3 · Cited by 37 · see citing works
Self-citationKumar, P., Slavich, G. M., Berghorst, L. H., Treadway, M. T., Brooks, N. H., Dutra, S. J., Greve, D. N., O’Donovan, A., Bleil, M. E., Maninger, N., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.035 · Cited by 36 · see citing works
Döbrössy, M. D., Ramanathan, C., Vajari, D. A., Tong, Y., Schlaepfer, T. E., & Coenen, V. A. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14975 · Cited by 36 · see citing works
Chang, R. S., Cerit, H., Hye, T., Durham, E. L., Aizley, H. G., Boukezzi, S. C., Haimovici, F., Goldstein, J. M., Dillon, D. G., Pizzagalli, D. A., et al. (2021) · Appetite · doi:10.1016/j.appet.2021.105707 · Cited by 35 · see citing works
Gill, K. M., & Grace, A. A. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000618 · Cited by 34 · see citing works
Self-citationImpaired contextual fear-conditioning in MAM rodent model of schizophrenia
Gill, K., Miller, S. A., & Grace, A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.08.064 · Cited by 28 · see citing works
Self-citationHausknecht, K. A., Haj‐Dahmane, S., & Shen, R. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.168 · Cited by 32 · see citing works
Physiology and Therapeutic Potential of SK, H, and M Medium AfterHyperPolarization Ion Channels
Dwivedi, D., & Bhalla, U. S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.658435 · Cited by 26 · see citing works
Yang, Y., Zhang, K., Zhong, J., Ju, W., Yu, Z., Lei, X., Chen, X., Quan, Y., Xian, J., Chen, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31056-7 · Cited by 26 · see citing works
Mesocortical BDNF signaling mediates antidepressive-like effects of lithium
Liu, D., Tang, Q., Wang, D., Song, S.-P., Yang, X.-N., Hu, S.-W., Wang, Z.-Y., Xu, Z., Liu, H., Yang, J., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0713-0 · Cited by 26 · see citing works
Lamanna, J., Isotti, F., Ferro, M., Spadini, S., Racchetti, G., Musazzi, L., & Malgaroli, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-14694-w · Cited by 26 · see citing works
Farghaly, H. S. M., Mahmoud, A. M., & Abdel-Sater, K. A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.02.046 · Cited by 25 · see citing works
Neves, G. A., & Grace, A. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0066-0 · Cited by 25 · see citing works
Self-citationInfluence of aging on the behavioral phenotypes of C57BL/6J mice after social defeat
Oizumi, H., Kuriyama, N., Imamura, S., Tabuchi, M., Omiya, Y., Mizoguchi, K., & Kobayashi, H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222076 · Cited by 24 · see citing works
Ironside, M., Moser, A. D., Holsen, L. M., Zuo, C. S., Du, F., Perlo, S., Richards, C. E., Duda, J. M., Chen, X., Nickerson, L. D. H., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01127-x · Cited by 23 · see citing works
Bai, M., Zhu, X., Zhang, L., Zhang, Y., Xue, L., Wang, Y., Zhong, M., & Zhang, X. (2017) · Brain and Behavior · doi:10.1002/brb3.808 · Cited by 23 · see citing works
Neves, G. A., & Grace, A. A. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.09.009 · Cited by 22 · see citing works
Self-citationRostrocaudal subregions of the ventral tegmental area are differentially impacted by chronic stress
Bambico, F. R., Li, Z., Oliveira, C., McNeill, S., Diwan, M., Raymond, R., & Nóbrega, J. N. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5177-8 · Cited by 20 · see citing works
Lamanna, J., Isotti, F., Ferro, M., Racchetti, G., Anchora, L., Rucco, D., & Malgaroli, A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24732 · Cited by 20 · see citing works
Altered monoamine system activities after prenatal and adult stress: A role for stress resilience?
Oosterhof, C. A., Mansari, M. E., Merali, Z., & Blier, P. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.032 · Cited by 20 · see citing works
Jia, J., He, L., Yang, J., Shuai, Y., Yang, J., Wu, Y., Liu, X., Chen, T., Wang, G., Wang, X., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023674118 · Cited by 19 · see citing works
Phillips, R., Walsh, E. C., Zürcher, N. R., Lalush, D. S., Kinard, J. L., Tseng, C.-E. J., Cernasov, P., Kan, D., Cummings, K. K., Kelley, L., et al. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111660 · Cited by 19 · see citing works
Lecca, S., Trusel, M., & Mameli, M. (2016) · Synapse · doi:10.1002/syn.21948 · Cited by 19 · see citing works
Azogu, I., & Plamondon, H. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.02.012 · Cited by 19 · see citing works
Zhang, M., Li, R., Wang, Y., & Huang, Z. (2017) · Neural Plasticity · doi:10.1155/2017/5870735 · Cited by 19 · see citing works
Lyle, N., Chakrabarti, S., Sur, T. K., Gomes, A., & Bhattacharyya, D. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0867-1 · Cited by 18 · see citing works
Stressed and wired: The effects of stress on the VTA circuits underlying motivated behavior
Lowes, D. C., & Harris, A. Z. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100388 · Cited by 18 · see citing works
Altered synaptic homeostasis: a key factor in the pathophysiology of depression
Wang, B., He, T., Qiu, G., Li, C., Xue, S., Zheng, Y., Wang, T., Xia, Y., Yao, L., Yan, J., et al. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01369-y · Cited by 19 · see citing works
Uliana, D. L., Gomes, F. V., & Grace, A. A. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.04.004 · Cited by 16 · see citing works
Self-citationSex‐Specific Adaptations to VTA Circuits Following Subchronic Stress
Bouarab, C., Wynalda, M., Thompson, B. V., Khurana, A., Cody, C. R., Kisner, A., & Polter, A. M. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70153 · Cited by 16 · see citing works
Haleem, D. J., Ikram, H., Haider, S., Parveen, T., & Haleem, M. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.011 · Cited by 15 · see citing works
Stress Controllability Modulates Basal Activity of Dopamine Neurons in the Substantia Nigra Compacta
Li, Y., Li, Y., Diao, Z., Di, Y., Wu, M., Wei, C., Qian, Z., Liu, Z., Han, J., Fan, J., et al. (2021) · eNeuro · doi:10.1523/eneuro.0044-21.2021 · Cited by 14 · see citing works
Faramarzi, G., Charmchi, E., Salehi, S., Zendehdel, M., & Haghparast, A. (2020) · European Journal of Pain · doi:10.1002/ejp.1716 · Cited by 14 · see citing works
Chen, N. A., Ganella, D. E., Bathgate, R. A. D., Chen, A., Lawrence, A. J., & Kim, J. H. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.06.002 · Cited by 14 · see citing works
Merdasi, P. G., Dezfouli, R. A., Mazaheri, S., & Haghparast, A. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113848 · Cited by 13 · see citing works
Keshavarzian, E., Ghasemzadeh, Z., & Rezayof, A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.05.008 · Cited by 13 · see citing works
Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience
Han, M., Russo, S. J., & Nestler, E. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00012-3 · Cited by 13 · see citing works
Bali, V., Simmons, S. C., Manning, C., Doyle, M. A., Rodriguez, M., Stark, A. R., Ayala-Rosario, S. N., Robison, A. J., & Mazei‐Robison, M. S. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.02.032 · Cited by 12 · see citing works
Wang, S., Huang, G., Yan, J. Y., Li, C., Feng, J., Chen, Q., Zheng, X., Li, H., Li, J., Wang, L., et al. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113486 · Cited by 11 · see citing works
Mortazaei, S., Sahraei, H., Bahari, Z., Meftahi, G. H., Jahromi, G. P., & Hatef, B. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1455711 · Cited by 11 · see citing works
Zadeh‐Tehrani, S. N., Sadat‐Shirazi, M., Akbarabadi, A., Aghadokht-Mamaghani, A., Soltani, H., Mokri, A., & Zarrindast, M. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146908 · Cited by 11 · see citing works
HCN channels: New targets for the design of an antidepressant with rapid effects
Luo, P., He, G., & Liu, D. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.081 · Cited by 11 · see citing works
Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)
Pavlou, I., Spandidos, D. A., Zoumpourlis, V. C., & Adamaki, M. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12262 · Cited by 11 · see citing works
Miceli, M. D., Husson, Z., Ruel, P., Layé, S., Cota, D., Fioramonti, X., Bosch‐Bouju, C., & Gronier, B. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00051 · Cited by 10 · see citing works
Yan, W., Gao, Q., Zhou, Y., Xu, P., Wu, Z., Yuan, T., Xie, L., You, Z., Zhang, X., Feng, B., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.07.007 · Cited by 9 · see citing works
Farahimanesh, S., Moradi, M., Nazari-Serenjeh, F., Zarrabian, S., & Haghparast, A. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000381 · Cited by 9 · see citing works
Schwab‐Reese, L. M., Parker, E. A., & Peek-Asa, C. L. (2017) · Journal of Interpersonal Violence · doi:10.1177/0886260517696841 · Cited by 9 · see citing works
Generation of Individualized, Standardized, and Electrically Synchronized Human Midbrain Organoids
Harane, S. E., Nazari, B., Harane, N. E., Locatelli, M., Zidi, B., Durual, S., Karmime, A., Ravier, F., Roux, A., Stoppini, L., et al. (2025) · Cells · doi:10.3390/cells14151211 · Cited by 8 · see citing works
Silvetti, M., Baldassarre, G., & Caligiore, D. (2019) · Springer series in cognitive and neural systems · doi:10.1007/978-3-030-18830-6_12 · Cited by 8 · see citing works
Mansari, M. E., Hamoudeh, R. A., Daniels, S., & Blier, P. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231209235 · Cited by 7 · see citing works
Nazari-Serenjeh, F., Sadeghi, M., Azizbeigi, R., Semizeh, H., Mazaheri, S., Haghparast, A., & Haghparast, A. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114914 · Cited by 7 · see citing works
Fletcher, P., Li, Z., Coen, K., & Lê, A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.028 · Cited by 8 · see citing works
Noursadeghi, E., & Haghparast, A. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.03.003 · Cited by 7 · see citing works
- Authors
- Valenti, O., Gill, K. M., & Grace, A. A.
- Affiliations
- University of Pittsburgh (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2012-04
- Volume
- 35
- Issue
- 8
- Pages
- 1312-1321
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC3335739
- OpenAlex
- W2104293622
- Cited by
- 131
- References
- 83
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 8 · 2014: 4 · 2013: 12 · 2012: 4
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH057440)
- National Institute on Drug Abuse (DA 15408, R56DA015408, R01DA015408)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mesolimbic dopamine system, ventral tegmental area, chronic cold stress, restraint stress, stress adaptation, amphetamine sensitization, ventral striatum, single-unit recording, stressor specificity
- MeSH terms
- Action Potentials, Afferent Pathways, Amphetamine, Analysis of Variance, Animals, Cold Temperature, Disease Models, Animal, Male, Motor Activity, Neural Inhibition, Restraint, Physical, Stress, Psychological, Time Factors, Dopamine Agents, Rats, Sprague-Dawley, Prefrontal Cortex, Ventral Tegmental Area, Rats, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
