Cited by 1,239Epigenetics and DNA MethylationBirth, Development, and HealthNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 288 of the 288 references it cites were found in a registry or an index.

Epigenetics and the biological definition of gene×environment interactions

Meaney, Michael J·2010·Child Development

Abstract

Variations in phenotype reflect the influence of environmental conditions during development on cellular functions, including that of the genome. The recent integration of epigenetics into developmental psychobiology illustrates the processes by which environmental conditions in early life structurally alter DNA, providing a physical basis for the influence of the perinatal environmental signals on phenotype over the life of the individual. This review focuses on the enduring effects of naturally occurring variations in maternal care on gene expression and phenotype to provide an example of environmentally driven plasticity at the level of the DNA, revealing the interdependence of gene and environmental in the regulation of phenotype.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1467-8624.2009.01381.x

Cites

288 of 288 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 287 references

Research works printed but not linked: 7

  1. Auerbach, 2002, Dopamine D4 receptor (D4DR) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants, Molecular Psychiatry, 4, 369, 10.1038/sj.mp.4000531 · DOI
  2. Hellstrom, 2009, Maternal regulation of glucocorticoid receptor expression through serotonin-induced nerve growth factor-inducible factor A signaling
  3. Hinde, 1986, Development of anti-social and prosocial behaviour, 13
  4. Meaney, 2000, Handling alters the expression of messenger RNAs for AP-2, NGFI-A and NGFI-B in the hippocampus of neonatal rats, Journal of Neuroscience, 20, 3936
  5. Shahrohk, Oxytocin–dopamine interactions in the ventral tegmental area mediate variations in maternal behaviour in the rat
  6. Uno, 1989, Hippocampal damage associated with prenatal glucocorticoid exposure, Developmental Brain Research, 9, 1705
  7. Zhang, 2009, Maternal regulation of glutamic acid decarboxylase 1 gene expression through DNA methylation

Cited by

Sorted by citations

Items 401–500 of 1,000

Metadata

Authors
Meaney, M. J.
Affiliations
McGill University (CA)
Corresponding author
Meaney, Michael J
Venue
Child Development
Published
2010-01-01
Volume
81
Issue
1
Pages
41-79
ISSN
  • 0009-3920 (ISSN-L)
  • 1467-8624
OpenAlex
W2128782957
Cited by
1,239
References
287
Citations by year
2026: 57 · 2025: 42 · 2024: 25 · 2023: 33 · 2022: 35 · 2021: 41 · 2020: 151 · 2019: 65 · 2018: 75 · 2017: 84 · 2016: 98 · 2015: 122 · 2014: 111 · 2013: 97 · 2012: 96
FWCI
8.37
Type
journal article
Language
en
Open access
closed
Locations
  • Child Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
epigenetics, gene-environment interaction, maternal care, early life environment, DNA methylation, gene expression, phenotypic plasticity, developmental psychobiology, perinatal environment
MeSH terms
Child, Child Development, Critical Period, Psychological, DNA, Humans, Maternal Behavior, Phenotype, Social Environment, Genome, Human, Gene Expression Regulation, Developmental, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review