Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson’s disease
Abstract
BACKGROUND: There is a growing number of clinical studies that revealed a variety of behavioral and physiological desynchronies in patients with Parkinson's disease (PD). However, these desynchronies have not been defined at the molecular level. METHODS: Using real-time RT-PCR assay, we analyzed the expression profiles of two principle clock genes, PER1 and BMAL1, in total leukocytes for 12 h during the evening, overnight and morning in subjects with PD and age/sex-matched healthy controls. RESULTS: A difference in the expression pattern of BMAL1 but not PER1 was apparent during the dark span, where the relative abundance of BMAL1 was significantly lower in PD patients versus control subjects at 21:00, 00:00 and 06:00 h. Furthermore, expression levels of BMAL1 in PD patients correlated with their United Parkinson's Disease Rating Scale score at 06:00, 09:00 h, and with Pittsburgh Sleep Quality Index score at 06:00 h. CONCLUSION: These results suggest that a peripheral molecular clock, as reflected in the dampened expression of the clock genes BMAL1 in total leukocytes, is altered in PD patients. In addition, the relative BMAL1 levels correlate positively with PD severity, which could provide a molecular basis to help monitor disease progression and response to investigational drugs.
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Expression levels of Bmal1 in Parkinson's disease patients correlated with PD severity as assessed by the Unified Parkinson Disease Rating Scale (UPDRS).
“Expression levels of Bmal1 patients correlated with PD severity as assessed by the Unified Parkinson Disease Rating Scale (UPDRS) (Cai et al., 2010).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Cai et al., 2010
Among 17 individuals with Parkinson's disease and 16 age-matched controls, the relative abundance of the clock gene Bmal1 was significantly lower during the night in PD patients.
“Among 17 individuals with PD and 16 age-matched controls, the relative abundance of the clock gene Bmal1 was significantly lower during the night in PD patients.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Cai et al., 2010
Cites
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234 · see citing works
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. A., & SEITELBERGER, F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90175-5 · Cited by 2,650 · see citing works
Molecular analysis of mammalian circadian rhythms
Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444 · see citing works
Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188 · see citing works
Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood
Hampp, G., Ripperger, J. A., Houben, T., Schmutz, I., Blex, C., Perreau‐Lenz, S., Brunk, I., Spanagel, R., Ahnert‐Hilger, G., Meijer, J. H., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.012 · Cited by 419 · see citing works
Circadian variation of blood pressure and the vascular response to asynchronous stress
Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 401 · see citing works
Circadian clock genes oscillate in human peripheral blood mononuclear cells
Boivin, D. B., James, F. O., Wu, A., Cho-Park, P. F., Xiong, H., & Sun, Z. S. (2003) · Blood · doi:10.1182/blood-2003-03-0779 · Cited by 340 · see citing works
Alterations of T-lymphocyte populations in Parkinson disease
Baba, Y., Kuroiwa, A., Uitti, R. J., Wszolek, Z. K., & Yamada, T. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2005.07.005 · Cited by 336 · see citing works
A role for cryptochromesin sleep regulation
Wisor, J. P., O’Hara, B. F., Terao, A., Selby, C. P., Kilduff, T. S., Sancar, A., Edgar, D. M., & Franken, P. (2002) · BMC Neuroscience · doi:10.1186/1471-2202-3-20 · Cited by 286 · see citing works
Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
Dardente, H., Dardente, H., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701283693 · Cited by 284 · see citing works
Cermakian, N., Monaco, L., Pando, M. P., Dierich, A., & Sassone‐Corsi, P. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.3967 · Cited by 252 · see citing works
Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1
Yujnovsky, I., Hirayama, J., Doi, M., Borrelli, E., & Sassone‐Corsi, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510691103 · Cited by 199 · see citing works
An Autonomous Circadian Clock in the Inner Mouse Retina Regulated by Dopamine and GABA
Ruan, G.-X., Allen, G. C., Yamazaki, S., & McMahon, D. G. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060249 · Cited by 164 · see citing works
Evidence supporting a circadian control of natural killer cell function
Arjona, A., & Sarkar, D. K. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.10.002 · Cited by 150 · see citing works
Dopamine receptor-mediated regulation of neuronal “clock” gene expression
Imbesi, M., Yildiz, S., Arslan, A. D., Sharma, R., Manev, H., & Uz, T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.044 · Cited by 141 · see citing works
Short Communication: The Circadian Gene mPer2 Regulates the Daily Rhythm of IFN- γ
Arjona, A., & Sarkar, D. K. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.645 · Cited by 121 · see citing works
Khaldy, H., León, J., Escames, G., Bikjdaouene, L., García, J. J., & Acuña-Castroviejo, D. (2002) · Neuroendocrinology · doi:10.1159/000048238 · Cited by 118 · see citing works
Willis, G. L. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.4-5.245 · Cited by 99 · see citing works
Circadian patterns of neurotransmitter related gene expression in motor regions of the rat brain
Weber, M., Lauterburg, T., Tobler, I., & Burgunder, J. ‐. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.053 · Cited by 94 · see citing works
MOP3, a component of the molecular clock, regulates the development of B cells
Sun, Y., Yang, Z., Niu, Z., Peng, J., Li, Q., Xiong, W., Langnas, A. N., Ma, M. Y. J., & Zhao, Y. L. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02456.x · Cited by 90 · see citing works
Liu, S., Cai, Y., Sothern, R. B., Guan, Y., & Chan, P. (2007) · Chronobiology International · doi:10.1080/07420520701672556 · Cited by 88 · see citing works
Bruguerolle, B., & Simon, N. (2002) · Clinical Neuropharmacology · doi:10.1097/00002826-200207000-00002 · Cited by 83 · see citing works
Circadian expression of clock genes in human peripheral leukocytes
Fukuya, H., Emoto, N., Nonaka, H., Yagita, K., Okamura, H., & Yokoyama, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.063 · Cited by 72 · see citing works
Chen, A., Du, L., Xu, Y., Chen, L., & Wu, Y. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000183663.98446.05 · Cited by 42 · see citing works
Nagashima, K., Matsue, K., Konishi, M., Iidaka, C., Miyazaki, K., Ishida, N., & Kanosue, K. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00395.2004 · Cited by 37 · see citing works
CatalÁ, M. D., Cañete-Nicolás, C., Iradi, A., Tarazona, F., Tormos, J. M., & Pascual‐Leone, Á. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00173-8 · Cited by 35 · see citing works
Torres‐Farfan, C., Abarzúa-Catalán, L., Valenzuela, F. J., Méndez, N., Richter, H. G., Valenzuela, G. J., & Serón‐Ferré, M. (2009) · Endocrinology · doi:10.1210/en.2008-1683 · Cited by 25 · see citing works
Variation in the Dopaminergic Response During the Day in Parkinson Disease
Monge, A., Viselli, F., Stocchi, F., Barbato, L., Bolner, A., Modugno, N., Paradiso, M., Ruggieri, S. A., & Nordera, G. P. (2004) · Clinical Neuropharmacology · doi:10.1097/00002826-200405000-00005 · Cited by 17 · see citing works
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Mechanisms linking circadian clocks, sleep, and neurodegeneration
Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878 · see citing works
Sleep and Circadian Rhythm Regulation in Early Parkinson Disease
Breen, D. P., Vuono, R., Nawarathna, U., Fisher, K., Shneerson, J. M., Reddy, A. B., & Barker, R. A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.65 · Cited by 440 · see citing works
'The clocks that time us'—circadian rhythms in neurodegenerative disorders
Videnović, A., Lázár, A. S., Barker, R. A., & Overeem, S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.206 · Cited by 373 · see citing works
Circadian Rhythms, Sleep, and Disorders of Aging
Mattis, J., & Sehgal, A. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.02.003 · Cited by 369 · see citing works
Pandi-Perumal, S. R., BaHammam, A. S., Brown, G. M., Spence, D. W., Bharti, V. K., Kaur, C., Hardeland, R., & Cardinali, D. P. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9337-4 · Cited by 320 · see citing works
Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health
Wilking, M. J., Ndiaye, M. A., Mukhtar, H., & Ahmad, N. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4889 · Cited by 324 · see citing works
The genetics of circadian rhythms, sleep and health
Jagannath, A., Taylor, L., Wakaf, Z., Vasudevan, S. R., & Foster, F. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx240 · Cited by 258 · see citing works
Circadian rhythms in neurodegenerative disorders
Nassan, M. M., & Videnović, A. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00577-7 · Cited by 259 · see citing works
Hood, S., Cassidy, P., Cossette, M.-P., Weigl, Y., Verwey, M., Robinson, B., Stewart, J., & Amir, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2128-10.2010 · Cited by 246 · see citing works
DNA methylation, a hand behind neurodegenerative diseases
Lu, H., Liu, X., Yu-Lin, D. E. N. G., & Qing, H. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00085 · Cited by 172 · see citing works
Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System
Korshunov, K. S., Blakemore, L. J., & Trombley, P. Q. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00091 · Cited by 173 · see citing works
Sundaram, S., Hughes, R. L., Peterson, E., Müller-Oehring, E. M., Brontë-Stewart, H. M., Poston, K. L., Faerman, A., Bhowmick, C., & Schulte, T. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.016 · Cited by 152 · see citing works
Neurodegeneration and the Circadian Clock
Hood, S., & Amir, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00170 · Cited by 150 · see citing works
Circadian clock disruption in neurodegenerative diseases: cause and effect?
Musiek, E. S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00029 · Cited by 120 · see citing works
Srinivasan, V., Cardinali, D. P., Srinivasan, U. S., Kaur, C., Brown, G. M., Spence, D. W., Hardeland, R., & Pandi-Perumal, S. R. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611406166 · Cited by 113 · see citing works
Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond
Morgia, C. L., Ross‐Cisneros, F. N., Sadun, A. A., & Carelli, V. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00162 · Cited by 111 · see citing works
Sleep and circadian rhythms in Parkinson’s disease and preclinical models
Hunt, J., Coulson, E. J., Rajnarayanan, R. V., Oster, H., Videnović, A., & Rawashdeh, O. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00504-w · Cited by 113 · see citing works
Liu, W., Wei, S., Huang, G., Liu, L.-B., Gu, C., Shen, Y., Wang, X., Xia, S., Xie, A., Hu, L., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901565rr · Cited by 106 · see citing works
Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese
Gu, Z., Wang, B., Zhang, Y., Ding, H., Zhang, Y., Yu, J. M., Gu, M., Chan, P., & Cai, Y. (2015) · Scientific Reports · doi:10.1038/srep15891 · Cited by 104 · see citing works
Implications of DNA Methylation in Parkinson’s Disease
Miranda-Morales, E. G., Meier, K., Sandoval-Carrillo, A. A., Salas-Pacheco, J. M., Vázquez-Cárdenas, P., & Arias-Carrión, Ó. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00225 · Cited by 105 · see citing works
Lecarpentier, Y., CLAES, V. A., Duthoit, G., & Hébert, J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00429 · Cited by 99 · see citing works
Chrono-biology, Chrono-pharmacology and Chrono-nutrition
Tahara, Y., & Shibata, S. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13r06cr · Cited by 94 · see citing works
An overview of sleep and circadian dysfunction in Parkinson's disease
Mantovani, S., Smith, S. S., Gordon, R., & O’Sullivan, J. D. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12673 · Cited by 97 · see citing works
Epigenetic Regulation of Neuroinflammation in Parkinson’s Disease
Rasheed, M., Liang, J., Wang, C., Deng, Y., & Chen, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094956 · Cited by 94 · see citing works
Anderson, G., & Maes, M. H. J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8554-z · Cited by 90 · see citing works
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Schurhoff, N. A., & Toborek, M. J. (2023) · Molecular Brain · doi:10.1186/s13041-023-00997-0 · Cited by 91 · see citing works
Troili, F., Cipollini, V., Moci, M., Morena, E., Palotai, M., Rinaldi, V., Romano, C., Ristori, G., Giubilei, F., Salvetti, M., et al. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.00017 · Cited by 91 · see citing works
A New Perspective for Parkinson’s Disease: Circadian Rhythm
Li, S., Wang, Y., Wang, F., Hu, L., & Liu, C. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0089-7 · Cited by 86 · see citing works
Neuroendocrine abnormalities in Parkinson's disease
Pablo‐Fernández, E. D., Breen, D. P., Bouloux, P. M., Barker, R. A., Foltynie, T., & Warner, T. T. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314601 · Cited by 83 · see citing works
Ortuño‐Lizarán, I., Esquiva, G., Beach, T. G., Serrano, G. E., Adler, C. H., Lax, P., & Cuenca, N. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0596-z · Cited by 87 · see citing works
Chronotype, social jet lag, sleep debt and food timing in inflammatory bowel disease
Chakradeo, P. S., Keshavarzian, A., Singh, S., Dera, A. E., Esteban, J. P., Lee, A. A., Burgess, H. J., Fogg, L., & Swanson, G. R. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.08.002 · Cited by 82 · see citing works
Shumay, E., Fowler, J. S., Wang, G.-J., Logan, J., Alia-Klein, N., Goldstein, R. Z., Maloney, T., Wong, C., & Volkow, N. D. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.11 · Cited by 79 · see citing works
Delgado-Lara, D. L. C., González-Enríquez, G. V., Torres-Mendoza, B. M., González-Usigli, H., Cárdenas-Bedoya, J., Macías-Islas, M. Á., de la Rosa, A. C., Jiménez-Delgado, A., Pacheco-Moisés, F. P., Serrano, J. A. C., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110485 · Cited by 80 · see citing works
Wang, Y., Lv, D.-J., Liu, W., Li, S., Chen, J., Shen, Y., Fen, W., Hu, L., & Liu, C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4854732 · Cited by 79 · see citing works
Kaur, G., Rathod, S. S. S., Ghoneim, M. M., Alshehri, S., Ahmad, J., Mishra, A., & Alhakamy, N. A. (2022) · Biology · doi:10.3390/biology11010090 · Cited by 79 · see citing works
Promoter methylation analysis of seven clock genes in Parkinson's disease
Lin, Q., Ding, H., Zheng, Z., Gu, Z., Ma, J., Chen, L., Chan, P., & Cai, Y. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.12.007 · Cited by 76 · see citing works
Consequences of Circadian Disruption on Neurologic Health
Videnović, A., & Zee, P. C. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.004 · Cited by 75 · see citing works
Gravotta, L., Gavrila, A. M., Hood, S., & Amir, S. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9520-8 · Cited by 74 · see citing works
Management of Sleep Disturbances in Parkinson’s Disease
Schütz, L., Sixel‐Döring, F., & Hermann, W. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-212749 · Cited by 77 · see citing works
Gabryelska, A., Turkiewicz, S., Karuga, F. F., Sochal, M., Strzelecki, D., & Białasiewicz, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020709 · Cited by 74 · see citing works
Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms
Tamtaji, O. R., Reiter, R. J., Alipoor, R., Dadgostar, E., Kouchaki, E., & Asemi, Z. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00720-5 · Cited by 73 · see citing works
Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
Fifel, K., & Videnović, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.627330 · Cited by 68 · see citing works
Curtis, W. M., Seeds, W. A., Mattson, M. P., & Bradshaw, P. C. (2022) · Cells · doi:10.3390/cells11152416 · Cited by 71 · see citing works
Physiological links of circadian clock and biological clock of aging
Liu, F., & Chang, H.-C. (2017) · Protein & Cell · doi:10.1007/s13238-016-0366-2 · Cited by 68 · see citing works
Teijido, Ó., & Cacabelos, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103199 · Cited by 68 · see citing works
Roles of clock genes in the pathogenesis of Parkinson's disease
Shkodina, A. D., Tan, S. C., Hasan, M. M., Abdelgawad, M., Chopra, H., Bilal, M., Boiko, D. I., Tarianyk, K. А., & Alexiou, A. T. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101554 · Cited by 65 · see citing works
Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson’s Disease
Perez‐Lloret, S., & Cardinali, D. P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.650597 · Cited by 64 · see citing works
Circadian dysregulation in Parkinson's disease
Videnovic, A., & Golombek, D. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.11.001 · Cited by 63 · see citing works
Fan, R., Peng, X., Xie, L., Dong, K., Ma, D., Xu, W., Shi, X., Zhang, S., Chen, J., Yu, X., et al. (2022) · Aging Cell · doi:10.1111/acel.13704 · Cited by 62 · see citing works
Mattam, U., & Jagota, A. (2014) · Biogerontology · doi:10.1007/s10522-014-9541-0 · Cited by 62 · see citing works
A lterations of the circadian system in P arkinson's disease patients
Fifel, K. (2016) · Movement Disorders · doi:10.1002/mds.26865 · Cited by 61 · see citing works
Neural function of Bmal1: an overview
Zheng, Y., Pan, L., Wang, F., Yan, J., Wang, T., Xia, Y., Yao, L., Deng, K., Zheng, Y., Xia, X., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-022-00947-8 · Cited by 60 · see citing works
Phillipson, O. T. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.006 · Cited by 60 · see citing works
Weissová, K., Škrabalová, J., Skálová, K., Červená, K., Bendová, Z., Miletínová, E., Kopřivová, J., Šonka, K., Dudysová, D., Bartoš, A., et al. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.07.019 · Cited by 59 · see citing works
Prasanth, M. I., Sivamaruthi, B. S., Cheong, C. S. Y., Verma, K., Tencomnao, T., Brimson, J. M., & Prasansuklab, A. (2024) · Antioxidants · doi:10.3390/antiox13050606 · Cited by 57 · see citing works
A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson’s Disease
Hayashi, A., Matsunaga, N., Okazaki, H., Kakimoto, K., Kimura, Y., Azuma, H., Ikeda, E., Shiba, T., Yamato, M., Yamada, K., et al. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8214-x · Cited by 56 · see citing works
Decreased expression of Bmal2 in patients with Parkinson's disease
Ding, H., Liu, S., Yuan, Y., Lin, Q., Chan, P., & Cai, Y. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.058 · Cited by 58 · see citing works
Wang, Y., Du, W., Hu, X., Yu, X., Guo, C., Jin, X., & Wang, W. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.009 · Cited by 56 · see citing works
Chronotherapies for Parkinson’s disease
Fifel, K., & Videnović, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.002 · Cited by 58 · see citing works
Sleep disturbance in movement disorders: insights, treatments and challenges
Bailey, G. A., Hubbard, E., Fasano, A. A., Tijssen, M. A. J., Lynch, T., Anderson, K. N., & Peall, K. J. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-325546 · Cited by 55 · see citing works
Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson’s disease in older men
Leng, Y., Goldman, S. M., Cawthon, P. M., Stone, K. L., Ancoli‐Israel, S., & Yaffe, K. S. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy098 · Cited by 54 · see citing works
Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson’s Disease
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2020) · Cells · doi:10.3390/cells9020314 · Cited by 54 · see citing works
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8486-x · Cited by 52 · see citing works
Kinoshita, C., Okamoto, Y., Aoyama, K., & Nakaki, T. (2020) · Clocks & Sleep · doi:10.3390/clockssleep2030022 · Cited by 48 · see citing works
Rest‐Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder
Feng, H., Chen, L., Liu, Y., Chen, X., Wang, J., Yu, M. W. M., Huang, B., Li, S. X., Chau, S. W. H., Chan, J. W. Y., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25853 · Cited by 44 · see citing works
Glucocorticoid Regulation of Clock Gene Expression in the Mammalian Limbic Forebrain
Segall, L. A., & Amir, S. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9341-1 · Cited by 45 · see citing works
Exosomes from Human Periapical Cyst-MSCs: Theranostic Application in Parkinson's Disease
Tatullo, M., Marrelli, B., Zullo, M. J., Codispoti, B., Paduano, F., Benincasa, C., Fortunato, F., Scacco, S., Zavan, B., & Cocco, T. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.41515 · Cited by 44 · see citing works
Extracellular Vesicles: Potential Participants in Circadian Rhythm Synchronization
Tao, S., & Guo, S. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.26518 · Cited by 43 · see citing works
Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back
Lazzari, F. D., Bisaglia, M., Zordan, M. A., & Sandrelli, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123911 · Cited by 45 · see citing works
Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism
Pacelli, C., Rotundo, G., Lecce, L., Menga, M., Bidollari, E., Scrima, R., Cela, O., Piccoli, C., Cocco, T., Vescovi, A. L., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112772 · Cited by 44 · see citing works
Zhong, G., Naismith, S. L., Rogers, N. L., & Lewis, S. J. G. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.04.020 · Cited by 39 · see citing works
Circadian rhythm alterations affecting the pathology of neurodegenerative diseases
Canever, J. B., Queiroz, L. Y., Soares, E. S., de Avelar, N. C. P., & Cimarosti, H. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15883 · Cited by 40 · see citing works
Peripheral Clock System Abnormalities in Patients With Parkinson’s Disease
Li, T., Cheng, C., Jia, C., Leng, Y., Jin, Q., Yu, H., Liu, Y., Wang, N., Yang, Y., Al‐Nusaif, M., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.736026 · Cited by 41 · see citing works
Parkinson's Disease and Sleep/Wake Disturbances
Swick, T. J. (2012) · Parkinson s Disease · doi:10.1155/2012/205471 · Cited by 41 · see citing works
de Bruin, V. M. S., Bittencourt, L., & Tufik, S. B. (2012) · European Neurology · doi:10.1159/000335078 · Cited by 39 · see citing works
Liu, Y., Niu, L., Liu, X., Cheng, C., & Le, W. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00711-x · Cited by 39 · see citing works
Integration of Melatonin Related Redox Homeostasis, Aging, and Circadian Rhythm
Yanar, K., Simsek, B., & Çakatay, U. (2018) · Rejuvenation Research · doi:10.1089/rej.2018.2159 · Cited by 37 · see citing works
Li, H., Song, S., Wang, Y., Huang, C., Zhang, F., Liu, J., & Hong, J. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9968-1 · Cited by 36 · see citing works
Fifel, K., & Videnović, A. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105029 · Cited by 35 · see citing works
Kanan, M. F., Sheehan, P. W., Haines, J. N., Gómez, P., Dhuler, A., Nadarajah, C. J., Wargel, Z. M., Freeberg, B. M., Nelvagal, H. R., Izumo, M., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.162771 · Cited by 37 · see citing works
Clinical correlates of cerebral white matter abnormalities in patients with Parkinson's disease
ten Harmsen, B. L., van Rumund, A., Aerts, M. B., Bergkamp, M. I., Esselink, R. A. J., Richard, E., Meijer, F. J. A., Bloem, B. R., & van Wamelen, D. J. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.12.029 · Cited by 33 · see citing works
Melanopsin Cell Dysfunction is Involved in Sleep Disruption in Parkinson’s Disease
Feigl, B., Dumpala, S., Kerr, G., & Zele, A. J. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-202178 · Cited by 34 · see citing works
Huang, S., Choi, M. H., Huang, H., Wang, X., Chang, Y. C., & Kim, J. Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108394 · Cited by 32 · see citing works
Insomnia in Parkinson’s Disease: Causes, Consequences, and Therapeutic Approaches
Duan, X., Liu, H., Hu, X., Yu, Q., Kuang, G., Liu, L., Zhang, S., Wang, X., Li, J., Yu, D., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04400-4 · Cited by 31 · see citing works
Circadian Dysfunction in a Rotenone-Induced Parkinsonian Rodent Model
Lax, P., Esquiva, G., Esteve-Rudd, J., Baño‐Otálora, B., Madrid, J. A., & Cuenca, N. (2012) · Chronobiology International · doi:10.3109/07420528.2011.649870 · Cited by 31 · see citing works
Chronobiology of Parkinson's disease: Past, present and future
Asadpoordezaki, Z., Coogan, A. N., & Henley, B. M. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15859 · Cited by 31 · see citing works
Zhang, J., Liu, S., Wu, Y., Tang, Z., Wu, Y., Qi, Y., Dong, F., & Wang, Y. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01440-7 · Cited by 29 · see citing works
Deciphering clock genes as emerging targets against aging
Zhu, Y., Liu, Y., Escames, G., Yang, Z. Z., Zhao, H., Lu, Q., Xue, C., Xu, D., Acuña-Castroviejo, D., & Yang, Y. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101725 · Cited by 31 · see citing works
Yang, C., Hwang, C., Lin, P., Chuang, J., Hsu, C., Lin, S.-F., & Yang, M. (2015) · Medicine · doi:10.1097/md.0000000000000978 · Cited by 28 · see citing works
Trujillo-Rangel, W. Á., Acuña-Vaca, S., Padilla-Ponce, D. J., García-Mercado, F. G., Torres-Mendoza, B. M., Pacheco-Moisés, F. P., Escoto-Delgadillo, M., García‐Benavides, L., & Delgado-Lara, D. L. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084401 · Cited by 27 · see citing works
Mazzoccoli, G., Sothern, R. B., Greco, A., Pazienza, V., Vinciguerra, M., Liu, S., & Cai, Y. (2011) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201102400406 · Cited by 27 · see citing works
Circadian clock and cell cycle: Cancer and chronotherapy
Yao, J., He, C., Zhao, W., Hu, N., & Long, D. (2021) · Acta Histochemica · doi:10.1016/j.acthis.2021.151816 · Cited by 28 · see citing works
Fighting Against the Clock: Circadian Disruption and Parkinson’s Disease
Chen, Y.-C., Wang, W., Lewis, S. J. G., & Wu, S. (2023) · Journal of Movement Disorders · doi:10.14802/jmd.23216 · Cited by 26 · see citing works
Yalçın, M., Grande, V., Outeiro, T. F., & Relógio, A. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01009-9 · Cited by 28 · see citing works
Sleep/wake problems in Parkinson’s disease: pathophysiology and clinicopathologic correlations
Ondo, W. G. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1239-6 · Cited by 26 · see citing works
Yang, Z., Zhang, X., Li, C., Chi, S., & Xie, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.592989 · Cited by 26 · see citing works
Predicted MicroRNAs for Mammalian Circadian Rhythms
Figueredo, D. D. S., Barbosa, M. R., Gitaí, D. L. G., & de Andrade, T. G. (2013) · Journal of Biological Rhythms · doi:10.1177/0748730413476827 · Cited by 26 · see citing works
Circadian regulation in aging: Implications for spaceflight and life on earth
Malhan, D., Schoenrock, B., Yalçın, M., Blottner, D., & Relógio, A. (2023) · Aging Cell · doi:10.1111/acel.13935 · Cited by 25 · see citing works
Sleep−wake cycle dysregulation in idiopathic REM sleep behaviour disorder
Liguori, C., Zuccarelli, V., Spanetta, M., Izzi, F., Mercuri, N. B., & Placidi, F. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13234 · Cited by 24 · see citing works
Yalçın, M., Malhan, D., Basti, A., Peralta, A. R., Ferreira, J. J., & Relógio, A. (2021) · Cancers · doi:10.3390/cancers13235978 · Cited by 24 · see citing works
- Authors
- Cai, Y., Liu, S., Sothern, R. B., Xu, S., & Chan, P.
- Affiliations
- Capital Medical University (CN)
- University of Minnesota (US)
- Corresponding author
- Xu, S.
- Chan, P.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2010-03-15
- Volume
- 17
- Issue
- 4
- Pages
- 550-554
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W1969022395
- Cited by
- 184
- References
- 28
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 12 · 2023: 24 · 2022: 15 · 2021: 15 · 2020: 17 · 2019: 7 · 2018: 15 · 2017: 13 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 7
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- Parkinson's disease, clock genes, Per1, Bmal1, circadian rhythm, leukocytes, circadian gene expression, disease severity, sleep quality, disease progression biomarkers
- MeSH terms
- Circadian Rhythm, Darkness, Female, Health Status, Humans, Leukocytes, Male, Middle Aged, Parkinson Disease, RNA, Messenger, Severity of Illness Index, Sleep Wake Disorders, Time Factors, Case-Control Studies, Photoperiod, Reverse Transcriptase Polymerase Chain Reaction, ARNTL Transcription Factors, Period Circadian Proteins
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