Cited by 94Circadian rhythm and melatoninPharmacogenetics and Drug MetabolismSleep and Work-Related Fatigue

Chrono-biology, Chrono-pharmacology and Chrono-nutrition

Open access
Tahara, Yu, Shibata, Shigenobu·2014·Journal of Pharmacological Sciences

Abstract

The circadian clock system in mammals drives many physiological processes including the daily rhythms of sleep-wake behavior, hormonal secretion, and metabolism. This system responds to daily environmental changes, such as the light-dark cycle, food intake, and drug administration. In this review, we focus on the central and peripheral circadian clock systems in response to drugs, food, and nutrition. We also discuss the adaptation and anticipation mechanisms of our body with regard to clock system regulation of various kinetic and dynamic pathways, including absorption, distribution, metabolism, and excretion of drugs and nutrients. "Chrono-pharmacology" and "chrono-nutrition" are likely to become important research fields in chrono-biological studies.

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  • Caffeine increases sleep onset latency, reduces total sleep duration and reduces sleep quality.

    “caffeine (increased sleep onset latency, reduced total sleep duration and reduced sleep quality) [39]”

    From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [39]

  • The internal clock can be altered by changing the timing and nature of food intake.

    “It has been suggested that the internal clock can be altered by changing the timing and nature of food intake [39].”

    From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [39]

  • Caffeine increases alertness by antagonising adenosine receptors, which leads to a reduction in the inclination to sleep.

    “Caffeine increases the state of alertness, antagonising adenosine receptors, which also leads to a reduction in the inclination to sleep [39].”

    From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [39]

  • Nutrients such as antioxidants, tryptophan-rich protein, carbohydrate, melatonin, micronutrients, and fruit can affect sleep.

    “Nutrients such as antioxidants, tryptophan rich protein, carbohydrate, melatonin, micronutrients and fruit can affect sleep [37,39,40].”

    From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [39]

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Authors
Tahara, Y., & Shibata, S.
Affiliations
Waseda University (JP)
Venue
Journal of Pharmacological Sciences
Published
2014
Volume
124
Issue
3
Pages
320-335
ISSN
  • 1347-8613 (ISSN-L)
  • 1347-8648
OpenAlex
W2046819164
Cited by
94
References
184
Citations by year
2026: 6 · 2025: 10 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 10 · 2020: 5 · 2019: 10 · 2018: 3 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 2
FWCI
0.64
Type
journal article
Language
en
Open access
Locations
  • Journal of Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fuji Foundation for Protein Research
  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Society for the Promotion of Science (25893265, 23659126, 23300278)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian clock, chrononutrition, chronobiology, timing of drug administration, dietary intake, light-dark cycle, drug absorption, drug metabolism, nutrient metabolism, circadian rhythm, sleep-wake behavior, hormone secretion
MeSH terms
Animals, Chronobiology Phenomena, Circadian Rhythm, Digestion, Eating, Energy Metabolism, Humans, Intestinal Absorption, Intestinal Mucosa, Nutritional Physiological Phenomena, Pharmacology

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