Chrono-biology, Chrono-pharmacology and Chrono-nutrition
Open accessAbstract
The circadian clock system in mammals drives many physiological processes including the daily rhythms of sleep-wake behavior, hormonal secretion, and metabolism. This system responds to daily environmental changes, such as the light-dark cycle, food intake, and drug administration. In this review, we focus on the central and peripheral circadian clock systems in response to drugs, food, and nutrition. We also discuss the adaptation and anticipation mechanisms of our body with regard to clock system regulation of various kinetic and dynamic pathways, including absorption, distribution, metabolism, and excretion of drugs and nutrients. "Chrono-pharmacology" and "chrono-nutrition" are likely to become important research fields in chrono-biological studies.
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Caffeine increases sleep onset latency, reduces total sleep duration and reduces sleep quality.
“caffeine (increased sleep onset latency, reduced total sleep duration and reduced sleep quality) [39]”
From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [39]
The internal clock can be altered by changing the timing and nature of food intake.
“It has been suggested that the internal clock can be altered by changing the timing and nature of food intake [39].”
From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [39]
Caffeine increases alertness by antagonising adenosine receptors, which leads to a reduction in the inclination to sleep.
“Caffeine increases the state of alertness, antagonising adenosine receptors, which also leads to a reduction in the inclination to sleep [39].”
From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [39]
Nutrients such as antioxidants, tryptophan-rich protein, carbohydrate, melatonin, micronutrients, and fruit can affect sleep.
“Nutrients such as antioxidants, tryptophan rich protein, carbohydrate, melatonin, micronutrients and fruit can affect sleep [37,39,40].”
From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [39]
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Nutrients, Clock Genes, and Chrononutrition
Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198 · see citing works
Sleep and Nutrition Interactions: Implications for Athletes
Doherty, R., Madigan, S., Warrington, G., & Ellis, J. (2019) · Nutrients · doi:10.3390/nu11040822 · Cited by 186 · see citing works
“Recently the term Chrononutrition has been used to describe the interaction between food and the circadian system [39].”
BackgroundInfluentialMolecular aspects of circadian pharmacology and relevance for cancer chronotherapy
Ozturk, N., Ozturk, D., Kavakli, I. H., & Okyar, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102168 · Cited by 106 · see citing works
- Authors
- Tahara, Y., & Shibata, S.
- Affiliations
- Waseda University (JP)
- Venue
- Journal of Pharmacological Sciences
- Publisher
- Japanese Pharmacological Society
- Published
- 2014
- Volume
- 124
- Issue
- 3
- Pages
- 320-335
- ISSN
- 1347-8613 (ISSN-L)
- 1347-8648
- OpenAlex
- W2046819164
- Cited by
- 94
- References
- 184
- Citations by year
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- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fuji Foundation for Protein Research
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (25893265, 23659126, 23300278)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, chrononutrition, chronobiology, timing of drug administration, dietary intake, light-dark cycle, drug absorption, drug metabolism, nutrient metabolism, circadian rhythm, sleep-wake behavior, hormone secretion
- MeSH terms
- Animals, Chronobiology Phenomena, Circadian Rhythm, Digestion, Eating, Energy Metabolism, Humans, Intestinal Absorption, Intestinal Mucosa, Nutritional Physiological Phenomena, Pharmacology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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