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Cited by 198Autism Spectrum Disorder ResearchFamily and Disability Support ResearchGenetics and Neurodevelopmental Disorders

Psychiatric disorders in parents of children with autism: a meta-analysis

Yirmiya, Nurit, Shaked, Michal·2005·Journal of Child Psychology and Psychiatry
DOI 10.1111/j.1469-7610.2004.00334.x
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Abstract

Background: The genetic basis of autism has received great attention during the last few years. The psychiatric status of parents of persons with autism has been studied as part of the broad phenotype of autism. Methods: In the current study we examined all studies in which psychiatric difficulties of parents of children with autism were compared to those of parents of other children, as part of the broad phenotype of autism. Results: Overall, when parents of children with autism were compared to all other parents taken together, i.e., parents of typically developing children grouped together with parents of children with diagnoses other than autism, they were found to have more psychiatric difficulties, but this finding was inconsistent. Once type of comparison group (e.g., Down Syndrome, learning disabilities) and method of assessing psychiatric difficulties (e.g., self‐report, clinical measures) were taken into account, different findings were yielded for the various comparison groups and methods of assessing psychiatric difficulties in parents, suggesting that parents of children with autism present more psychiatric difficulties, mostly in comparisons involving samples of parents of children with no known genetic risk (e.g., Down Syndrome). Conclusions: These findings suggest that in future studies, researchers should carefully consider the advantages and disadvantages of various comparison groups and other characteristics, such as method of assessment, gender, and level of functioning, in attempting to delineate the specificity and universality of the broad phenotype of autism.

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  • Two meta-analyses underlined the lack of studies with psychiatric diagnosis of parents before the birth of children with autism, suggesting that depression during pregnancy may be underestimated.

    “two meta-analyses (52, 97) underlined the lack of studies with psychiatric diagnosis of parents before the birth of children with autism, suggesting that depression during pregnancy may be underestimated.”

    From Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms (2014) · cites this paper as [97]

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Authors
Yirmiya, N., & Shaked, M.
Affiliations
Hebrew University of Jerusalem (IL)
Corresponding author
Yirmiya, Nurit
Venue
Journal of Child Psychology and Psychiatry
Publisher
Wiley
Published
2004-08-11
Volume
46
Issue
1
Pages
69-83
ISSN
  • 0021-9630 (ISSN-L)
  • 1469-7610
DOI
10.1111/j.1469-7610.2004.00334.x
OpenAlex
W2156078552
Cited by
198
References
67
Citations by year
2026: 7 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 16 · 2019: 9 · 2018: 10 · 2017: 15 · 2016: 9 · 2015: 6 · 2014: 15 · 2013: 8 · 2012: 13
FWCI
0.54
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Child Psychology and Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, parents of autistic children, mental illness, genetic risk, Down syndrome, learning disabilities, comparison groups, self-report measures, clinical measures
MeSH terms
Adult, Autistic Disorder, Mental Disorders, Child, Female, Humans, Male, Parent-Child Relations, Phenotype, Risk Factors, Incidence

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