Concordance for the syndrome of autism in 40 pairs of afflicted twins
Abstract
The UCLA Registry for Genetic Studies in Autism was established in 1980 to test the hypothesis that genetic factors may be etiologically significant in subsets of patients. To date 61 pairs of twins have enrolled and 40 meet research diagnostic criteria for autism. The authors found a concordance for autism in these 40 pairs of 95.7% in the monozygotic twins (22 of 23) and 23.5% in the dizygotic twins (four of 17).
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More than half of the risk of developing ASD is attributable to genetic variation.
“Studies making use of twin pairs (7)(8)(9)(10)(11), families (12) and populations (11,13) have provided estimates that over half of risk of developing ASD resides with genetic variation”
From Genetics and genomics of autism spectrum disorder: embracing complexity (2015) · cites this paper as [8]
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- Authors
- RITVO, E. R., Freeman, B. J., MASON-BROTHERS, A., Mo, A., & Ritvo, A.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- American Journal of Psychiatry
- Published
- 1985-01-01
- Volume
- 142
- Issue
- 1
- Pages
- 74-77
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1717251174
- Cited by
- 378
- References
- 23
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 15 · 2015: 14 · 2014: 15 · 2013: 13 · 2012: 22
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 31274, MH 30897)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-04612)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- autism spectrum disorder, twin concordance, monozygotic twins, dizygotic twins, genetic etiology, twin registry
- MeSH terms
- Adolescent, Adult, Age Factors, Autistic Disorder, Birth Order, Child, Child, Preschool, Diseases in Twins, Female, Humans, Male, Models, Genetic, Pregnancy, Registries, Sex Factors, Twins, Dizygotic, Twins, Monozygotic, United States
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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