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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. Des, Patlak, C. S., Pettigrew, K. D., Sakurada, O., Shinohara, M.·1977·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.1977.tb10649.x

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Abstract

Abstract— A method has been developed for the simultaneous measurement of the rates of glucose consumption in the various structural and functional components of the brain in vivo. The method can be applied to most laboratory animals in the conscious state. It is based on the use of 2‐deoxy‐D‐[ 14 C]glucose ([ 14 C]DG) as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues. [ 14 C]DG is used because the label in its product, [ 14 C]deoxyglucose‐6‐phosphate, is essentially trapped in the tissue over the time course of the measurement. A model has been designed based on the assumptions of a steady state for glucose consumption, a first order equilibration of the free [ 14 C]DG pool in the tissue with the plasma level, and relative rates of phosphorylation of [ 14 C]DG and glucose determined by their relative concentrations in the precursor pools and their respective kinetic constants for the hexokinase reaction. An operational equation based on this model has been derived in terms of determinable variables. A pulse of [ 14 C]DG is administered intravenously and the arterial plasma [ 14 C]DG and glucose concentrations monitored for a preset time between 30 and 45min. At the prescribed time, the head is removed and frozen in liquid N 2 ‐chilled Freon XII, and the brain sectioned for autoradiography. Local tissue concentrations of [ 14 C]DG are determined by quantitative autoradiography. Local cerebral glucose consumpt…

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Methods of Enzymatic Analysis
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078
A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSE
Nelson, N. (1944) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71980-7 · Cited by 10,376
Methods of enzymatic analysis
Merritt, A. J. (1964) · Microchemical Journal · doi:10.1016/0026-265x(64)90139-0 · Cited by 5,180
Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., & Schulz, D. W. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51740-3 · Cited by 2,222
Cerebral Blood Flow and Oxygen Consumption in Man
Lassen, N. A. (1959) · Physiological Reviews · doi:10.1152/physrev.1959.39.2.183 · Cited by 2,101
THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES 1
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101994 · Cited by 2,058
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.6.1629 · Cited by 1,691
MICRODETERMINATION OF OXYHEMOGLOBIN, METHEMOGLOBIN, AND SULFHEMOGLOBIN IN A SINGLE SAMPLE OF BLOOD
Evelyn, K. A., & Malloy, H. T. (1938) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)73873-8 · Cited by 1,163
Localization of the primary metabolic block produced by 2-deoxyglucose
Wick, A. N., Drury, D. R., Nakada, H. I., Wolfe, J. B., Britton, B., & Grabowski, R. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64988-9 · Cited by 780
SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE
Sols, A., & Crane, R. K. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65384-0 · Cited by 599

Show all 36 references

Research works printed but not linked: 13

Rosiers M. H., 1974, Neurology, 24, 389
Dixon M., 1964, Enzymes, 84
Hers H. G., 1950, Bull. Soc. chem. Biol., 32, 20
Kennedy C., 1974, Trans. Am. Soc. Neurochem., 5, 86
Kety S. S., 1960, Meth. Med. Res., 8, 228
KnottG. D.&ReeceD. K.(1972) inProc. ONLINE ′72 International Conference Vol. 1 pp.497–526. Brunel University England.
Landau W. H., 1955, Trans. Am. Neurol. Ass., 80, 125
Plum F., 1976, Neurosci. Res. Prog. Bull., 14, 457
Saifer A., 1958, J. Lab. Clin. Med., 51, 448
Sokoloff L., 1960, Handbook of Physiology‐Neurophysiology, 1843
Sokoloff L., 1969, Psychochemical Research in Man, 237
Sokoloff L., 1974, Trans. Am. Soc. Neurochem., 5, 85
Sokoloff L., 1976, Basic Neurochemistry, 388

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Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease.
Rougemont, D., Baron, J., Collard, P., Bustany, P., Comar, D., & Agid, Y. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.8.824 · Cited by 95
Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects
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Riva, M. A., Gale, K., & Mocchetti, I. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90123-s · Cited by 94
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Bonetti, E. P., Burkard, W. P., Gabl, M., Hunkeler, W., Lorez, H., Martin, J. R., Möhler, H., Osterrieder, W., Pieri, L., Polc, P., et al. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90259-6 · Cited by 93
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Green, L. A., Gambhir, S. S., Srinivasan, A., Banerjee, P. K., Hoh, C. K., Cherry, S. R., Sharfstein, S. T., Barrio, J. R., Herschman, H. R., & Phelps, M. E. (1998) · PubMed · Cited by 92
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Reno, C. M., Puente, E. C., Sheng, Z., Daphna-Iken, D., Bree, A. J., Routh, V. H., Kahn, B. B., & Fisher, S. J. (2016) · Diabetes · doi:10.2337/db16-0917 · Cited by 97
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Sex differences and lateralization in temporal lobe glucose metabolism during mathematical reasoning
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Exo-focal postischemic neuronal death in the rat brain
Nagasawa, H., & Kogure, K. (1990) · Brain Research · doi:10.1016/0006-8993(90)90690-d · Cited by 92
EFFECTS OF γ‐BUTYROLACTONE ON LOCAL CEREBRAL GLUCOSE UTILIZATION IN THE RAT
WOLFSON, L. I., Sakurada, O., & Sokoloff, L. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10718.x · Cited by 92
Self-citation
Modulation of substrate transport to the brain
GJEDDE, A. H. (1983) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1983.tb04541.x · Cited by 92
Intraperitoneal administration and other modifications of the 2-deoxy-d-glucose technique
Meibach, R. C., Glick, S. D., Ross, D. A., Cox, R. D., & Maayani, S. (1980) · Brain Research · doi:10.1016/0006-8993(80)90874-4 · Cited by 92
Positron emission tomography of the heart
Bergmann, S. R., Fox, K. A. A., Geltman, E. M., & Sobel, B. E. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(85)90014-3 · Cited by 92
Multiparametric Imaging of Blood Flow and Metabolism after Middle Cerebral Artery Occlusion in Cats
Hossmann, K., Mies, G., Paschen, W., Csiba, L., Bodsch, W., Rapin, J. R., Poncin-Lafitte, M. L., & Takahashi, K. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.13 · Cited by 92
Localization of [3H]-2-deoxy glucose in single molluscan neurones
B, T. J. S. A., Reingold, S. C., Kelley, D. B., & Gelperin, A. (1980) · Nature · doi:10.1038/287449a0 · Cited by 92
Computer assisted analysis of 2-DG autoradiographs.
Gallistel, C., Piner, C., Allen, T. O., Adler, N. T., Yadin, E., & Negin, M. (1982) · Neuroscience and Biobehavioral Reviews · doi:10.1016/0149-7634(82)90024-0 · Cited by 93
A [14C]2-deoxyglucose analysis of the functional neural pathways of the limbic forebrain in the rat. I. The amygdala
Watson, R. E., Troiano, R. A., Poulakos, J. J., Weiner, S., Block, C. H., & Siegel, A. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90020-6 · Cited by 92
Aspects of oxygen and glucose consumption in the retina: Effects of high intraocular pressure and light
Bill, A., & Sperber, G. O. (1990) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00935720 · Cited by 91
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Duelli, R., Maurer, M. H., Staudt, R., Heiland, S., Dümbgen, L., & Kuschinsky, W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01942-9 · Cited by 91
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Clark, C. M., Li, D., Conry, J. L., Conry, R. F., & Loock, C. (2000) · PEDIATRICS · doi:10.1542/peds.105.5.1096 · Cited by 91
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Volkow, N. D., Wang, G., Overall, J. E., HITZEMANN, R. J., Fowler, J. S., Pappas, N. R., Frecska, E., & Piscani, K. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04449.x · Cited by 91
Cerebellar metabolic activation by delta-9-tetrahydrocannabinol in human brain: A study with positron emission tomography and 18F-2-Fluoro-2-deoxyglucose
Volkow, N. D., Gillespie, H. K., Mullani, N. A., Tancredi, L., Grant, C., Ivanović, M., & Hollister, L. E. (1991) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(91)90030-t · Cited by 91
Quantitative evaluation of regional substrate metabolism in the human heart by positron emission tomography
Hicks, R. J., Herman, W. H., Kalff, V., Molina, E., Wolfe, E. R., Hutchins, G. D., & Schwaiger, M. (1991) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80225-6 · Cited by 91
Positron Emission Tomographic Imaging of Serotonin Activation Effects on Prefrontal Cortex in Healthy Volunteers
Mann, J. J., Malone, K. M., Diehl, D. J., Perel, J. M., Nichols, T. E., & Mintun, M. A. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199605000-00008 · Cited by 91
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Cholet, N., Pellerin, L., Welker, E., Lacombe, P. M., Seylaz, J., Magistretti, P. J., & Bonvento, G. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200104000-00009 · Cited by 90
Positron emission tomography for staging and management of malignant melanoma
Prichard, R. S., Hill, A. D. K., Skehan, S. J., & O’Higgins, N. J. (2002) · British journal of surgery · doi:10.1046/j.0007-1323.2002.02059.x · Cited by 90
Nitrous oxide analgesia for minor pediatric surgical procedures: an effective alternative to conscious sedation?
Burnweit, C. A., Zerpa, J., Nahmad, M., Lankau, C. A., Weinberger, M., Malvezzi, L., Smith, L., Shapiro, T., & Thayer, K. (2004) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2003.11.037 · Cited by 92
Widespread Metabolic Depression and Reduced Somatosensory Circuit Activation Following Traumatic Brain Injury in Rats
Dietrich, W. D., Alonso, O. F., Busto, R., & Ginsberg, M. D. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.629 · Cited by 90
Postnatal Changes in Local Cerebral Blood Flow Measured by the Quantitative Autoradiographic [ 14 C]Iodoantipyrine Technique in Freely Moving Rats
Nehlig, A., de Vasconcelos, A. P., & Boyet, S. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.83 · Cited by 90
Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats
Yang, G., Chen, G., Ebner, T. J., & Iadecola, C. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.6.r1760 · Cited by 90
Visual evoked potentials and positron emission tomographic mapping of regional cerebral blood flow and cerebral metabolism: Can the neuronal potential generators be visualized?
Celesia, G. G., Polcyn, R. D., Holden, J. E., Nickles, R. J., Gatley, J. S., & Koeppe, R. A. (1982) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(82)90174-2 · Cited by 90
A magnetic device to stimulate selected whiskers of freely moving or restrained small rodents: its application in a deoxyglucose study
Melzer, P., der Loos, H. V., Dörfl, J., Welker, E., Robert, P., Émery, D., & Berrini, J.-C. (1985) · Brain Research · doi:10.1016/0006-8993(85)90441-x · Cited by 90
Acute Cerebral Ischaemia: Concurrent Changes in Cerebral Blood Flow, Energy Metabolites, pH, and Lactate Measured with Hydrogen Clearance and 31 P and 1 H Nuclear Magnetic Resonance Spectroscopy. I. Methodology
Gadian, D. G., Frackowiak, R. S. J., Crockard, H. A., Proctor, E., Allen, K. L., Williams, S. R., & Russell, R. W. R. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.45 · Cited by 90
A New Method to Measure Brain Serotonin Synthesis in vivo. II. A Practical Autoradiographic Method Tested in Normal and Lithium-Treated Rats
Nagahiro, S., Takada, A., Dikšić, M., Sourkes, T. L., Missala, K., & Yamamoto, Y. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.2 · Cited by 90
Increases in both cerebral glucose utilization and blood flow during execution of a somatosensory task
Ginsberg, M. D., Chang, J. Y., Kelley, R. E., Yoshii, F., Barker, W., Ingenito, G. G., & Boothe, T. E. (1988) · Annals of Neurology · doi:10.1002/ana.410230208 · Cited by 90
Distribution of effects of haloperidol on energy metabolism in the rat brain
McCulloch, J., Savaki, H. E., & Sokoloff, L. (1982) · Brain Research · doi:10.1016/0006-8993(82)91122-2 · Cited by 90
Self-citation
In vivo 18F-FDG tumour uptake measurements in small animals using Cerenkov radiation
Boschi, F., Calderan, L., D’Ambrosio, D., Marengo, M., Fenzi, A., Calandrino, R., Sbarbati, A., & Spinelli, A. E. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1630-y · Cited by 89
FAT/CD36: A Major Regulator of Neuronal Fatty Acid Sensing and Energy Homeostasis in Rats and Mice
Foll, C. L., Dunn-Meynell, A. A., Musatov, S., Magnan, C., & Levin, B. E. (2013) · Diabetes · doi:10.2337/db12-1689 · Cited by 90
G lia in brain energy metabolism: A perspective
Barros, L. F., Brown, A. M., & Swanson, R. A. (2018) · Glia · doi:10.1002/glia.23316 · Cited by 94
Glucose metabolism impairment in Parkinson’s disease
Dai, C., Tan, C., Zhao, L., Liang, Y., Liu, G., Liu, H., Zhong, Y., Liu, Z., Mo, L., Liu, X., et al. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110672 · Cited by 93
Insulin-Mediated Hepatic Glucose Uptake Is Impaired in Type 2 Diabetes: Evidence for a Relationship with Glycemic Control
Iozzo, P., Hällsten, K., Oikonen, V., Virtanen, K. A., Kemppainen, J., Solin, O. H., Ferrannini, E., Knuuti, J. M., & Nuutila, P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021446 · Cited by 89
Assessment of Lung Inflammation With18F-FDG PET During Acute Lung Injury
de Prost, N., Tucci, M. R., & Melo, M. F. V. (2010) · American Journal of Roentgenology · doi:10.2214/ajr.10.4499 · Cited by 91
Enhancement of insulin‐stimulated myocardial glucose uptake in patients with Type 2 diabetes treated with rosiglitazone
Hällsten, K., Virtanen, K. A., Lönnqvist, F., Janatuinen, T., Turiceanu, M., Rönnemaa, T., Viikari, J. S. A., Lehtimäki, T. J., Knuuti, J. M., & Nuutila, P. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01332.x · Cited by 91
Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: Results from a randomized clinical trial
Koffert, J., Mikkola, K., Virtanen, K. A., Andersson, A. D., Faxius, L., Hällsten, K., Heglind, M., Guiducci, L., Pham, T. T., Silvola, J. M. U., et al. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.07.015 · Cited by 91
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Porrino, L., Lyons, D. J., Miller, M. D., Smith, H. R., Friedman, D. P., Daunais, J., & Nader, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07687.2002 · Cited by 96
Heterogeneous cerebral glucose metabolism in normal pressure hydrocephalus.
Tedeschi, E., Hasselbalch, S. G., Waldemar, G., Juhler, M., Høgh, P., Holm, S., Garde, L., Knudsen, L., Klinken, L., & Gjerris, F. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.59.6.608 · Cited by 89
The neuroanatomical basis of anxiety
Pratt, J. A. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90014-q · Cited by 89
Degeneration of thalamic neurons in “Purkinje cell degeneration” mutant mice. I. Distribution of neuron loss
O’Gorman, S., & Sidman, R. L. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902340302 · Cited by 89
Post‐ischemic coma in rat: effect of different pre‐ischemic blood glucose levels on cerebral metabolic recovery after ischemia
Siemkowicz, E., & GJEDDE, A. H. (1980) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1980.tb06658.x · Cited by 89
Serotonin2/1 C receptor activation causes a localized expression of the immediate-early gene c-fos in rat brain: evidence for involvement of dorsal raphe nucleus projection fibres
Leslie, R. A., Moorman, J. M., Coulson, A., & Smith, A. D. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90209-x · Cited by 89
Area-at-risk determination by technetium-99m-hexakis-2-methoxyisobutyl isonitrile in experimental reperfused myocardial infarction.
Coster, P. M. D., Wijns, W. C., Cauwe, F., Robert, A. R., Beckers, C., & Melin, J. A. (1990) · Circulation · doi:10.1161/01.cir.82.6.2152 · Cited by 89
Metabotropic Glutamate Agonist-Induced Rotation: A Pharmacological, FOS Immunohistochemical, and [14C]-2-Deoxyglucose Autoradiographic Study
Kearney, J. A., Frey, K. A., & Albin, R. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04415.1997 · Cited by 89
Adaptation of the quantitative 2-[14C]deoxyglucose method for use in freely moving rats
Crane, A. M., & Porrino, L. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)91137-2 · Cited by 89
Maps of complex motion selectivity in the superior temporal cortex of the alert macaque monkey: a double-label 2-deoxyglucose study
Geesaman, B. J. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.8.749 · Cited by 89
Adult fragile X syndrome: neuropsychology, brain anatomy, and metabolism
Schapiro, M. B., Murphy, D. G. M., Hagerman, R. J., Azari, N. P., Alexander, G. E., Miezejeski, C. M., Hinton, V. J., Horwitz, B., Haxby, J. V., Kumar, A., et al. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600603 · Cited by 85
The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions
Takalo, M., Wittrahm, R., Wefers, B., Parhizkar, S., Jokivarsi, K., Kuulasmaa, T., Mäkinen, P., Martiskainen, H., Wurst, W., Xiang, X., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00402-7 · Cited by 83
Ethanol Reduces Metabolic Uncoupling Following Experimental Head Injury
KELLY, D. F., KOZLOWSKI, D. A., HADDAD, E., ECHIVERRI, A., HOVDA, D. A., & LEE, S. M. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.261 · Cited by 82

Authors: Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M.
Affiliations: National Institutes of Health (US)
University of Pennsylvania (US)
National Institute of Mental Health (US)
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 1977-05
Volume: 28
Issue: 5
Pages: 897-916
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.1977.tb10649.x
OpenAlex: W2090306035
Cited by: 6,000
References: 36
Citations by year: 2026: 22 · 2025: 37 · 2024: 45 · 2023: 44 · 2022: 64 · 2021: 60 · 2020: 78 · 2019: 63 · 2018: 70 · 2017: 67 · 2016: 73 · 2015: 68 · 2014: 97 · 2013: 95 · 2012: 101
FWCI: 22.51
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10748 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: local cerebral glucose utilization, 14C-deoxyglucose, hexokinase, autoradiography, auditory cortex, medial geniculate body, superior olive, inferior colliculus, thiopental anesthesia, conscious rats, brain energy metabolism, regional cerebral blood flow
MeSH terms: Anesthesia, Animals, Antipyrine, Autoradiography, Blood Glucose, Brain, Deoxy Sugars, Deoxyglucose, Glucose, Hexokinase, Kinetics, Male, Mathematics, Methylglucosides, Models, Biological, Thiopental, Rats

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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

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