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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. Des, Patlak, C. S., Pettigrew, K. D., Sakurada, O., Shinohara, M.·1977·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.1977.tb10649.x

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Abstract

Abstract— A method has been developed for the simultaneous measurement of the rates of glucose consumption in the various structural and functional components of the brain in vivo. The method can be applied to most laboratory animals in the conscious state. It is based on the use of 2‐deoxy‐D‐[ 14 C]glucose ([ 14 C]DG) as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues. [ 14 C]DG is used because the label in its product, [ 14 C]deoxyglucose‐6‐phosphate, is essentially trapped in the tissue over the time course of the measurement. A model has been designed based on the assumptions of a steady state for glucose consumption, a first order equilibration of the free [ 14 C]DG pool in the tissue with the plasma level, and relative rates of phosphorylation of [ 14 C]DG and glucose determined by their relative concentrations in the precursor pools and their respective kinetic constants for the hexokinase reaction. An operational equation based on this model has been derived in terms of determinable variables. A pulse of [ 14 C]DG is administered intravenously and the arterial plasma [ 14 C]DG and glucose concentrations monitored for a preset time between 30 and 45min. At the prescribed time, the head is removed and frozen in liquid N 2 ‐chilled Freon XII, and the brain sectioned for autoradiography. Local tissue concentrations of [ 14 C]DG are determined by quantitative autoradiography. Local cerebral glucose consumpt…

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Methods of Enzymatic Analysis
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078
A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSE
Nelson, N. (1944) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71980-7 · Cited by 10,376
Methods of enzymatic analysis
Merritt, A. J. (1964) · Microchemical Journal · doi:10.1016/0026-265x(64)90139-0 · Cited by 5,180
Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., & Schulz, D. W. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51740-3 · Cited by 2,222
Cerebral Blood Flow and Oxygen Consumption in Man
Lassen, N. A. (1959) · Physiological Reviews · doi:10.1152/physrev.1959.39.2.183 · Cited by 2,101
THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES 1
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101994 · Cited by 2,058
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.6.1629 · Cited by 1,691
MICRODETERMINATION OF OXYHEMOGLOBIN, METHEMOGLOBIN, AND SULFHEMOGLOBIN IN A SINGLE SAMPLE OF BLOOD
Evelyn, K. A., & Malloy, H. T. (1938) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)73873-8 · Cited by 1,163
Localization of the primary metabolic block produced by 2-deoxyglucose
Wick, A. N., Drury, D. R., Nakada, H. I., Wolfe, J. B., Britton, B., & Grabowski, R. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64988-9 · Cited by 780
SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE
Sols, A., & Crane, R. K. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65384-0 · Cited by 599

Show all 36 references

Research works printed but not linked: 13

Rosiers M. H., 1974, Neurology, 24, 389
Dixon M., 1964, Enzymes, 84
Hers H. G., 1950, Bull. Soc. chem. Biol., 32, 20
Kennedy C., 1974, Trans. Am. Soc. Neurochem., 5, 86
Kety S. S., 1960, Meth. Med. Res., 8, 228
KnottG. D.&ReeceD. K.(1972) inProc. ONLINE ′72 International Conference Vol. 1 pp.497–526. Brunel University England.
Landau W. H., 1955, Trans. Am. Neurol. Ass., 80, 125
Plum F., 1976, Neurosci. Res. Prog. Bull., 14, 457
Saifer A., 1958, J. Lab. Clin. Med., 51, 448
Sokoloff L., 1960, Handbook of Physiology‐Neurophysiology, 1843
Sokoloff L., 1969, Psychochemical Research in Man, 237
Sokoloff L., 1974, Trans. Am. Soc. Neurochem., 5, 85
Sokoloff L., 1976, Basic Neurochemistry, 388

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Self-citation
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Self-citation
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Self-citation
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Silverman, M. S., & Tootell, R. B. H. (1987) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(87)90016-1 · Cited by 108
Comparison of metabolic rates, language, and memory in subcortical aphasias
Metter, E. J., Riege, W. H., Hanson, W., Kuhl, D. E., Phelps, M. E., Squire, L. R., Wasterlain, C. G., & Benson, D. F. (1983) · Brain and Language · doi:10.1016/0093-934x(83)90054-8 · Cited by 108
Quantitative in vivo autoradiography with positron emission tomography
Raichle, M. E. (1979) · Brain Research Reviews · doi:10.1016/0165-0173(79)90016-x · Cited by 108
Inhibition of nitric oxide synthase does not prevent the induction of long-term potentiation in vivo
Bannerman, D. M., Chapman, P., Kelly, P., Butcher, S., & Morris, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07415.1994 · Cited by 108
PET radiotracers for molecular imaging in the brain: Past, present and future
Zimmer, L., & Luxen, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.037 · Cited by 114
PET/CT in Oncology: Current Status and Perspectives
Czernin, J. G., Allen-Auerbach, M., Nathanson, D. A., & Herrmann, K. (2013) · Current Radiology Reports · doi:10.1007/s40134-013-0016-x · Cited by 112
Effects of Glucose Deprivation, Chemical Hypoxia, and Simulated Ischemia on Na+Homeostasis in Rat Spinal Cord Astrocytes
Rose, C. R., Waxman, S. G., & Ransom, B. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03554.1998 · Cited by 107
Functional mapping of neural pathways in rodent brain in vivo using manganese‐enhanced three‐dimensional magnetic resonance imaging
Watanabe, T., Frahm, J., & Michaelis, T. (2004) · NMR in Biomedicine · doi:10.1002/nbm.937 · Cited by 107
Imaging brain activation induced by long trains of repetitive transcranial magnetic stimulation
Siebner, H. R., Willoch, F., Peller, M., Auer, C., Boecker, H., Conrad, B., & Bartenstein, P. (1998) · Neuroreport · doi:10.1097/00001756-199803300-00033 · Cited by 107
Regional cerebral glucose metabolism and postmortem pathology in Alzheimer’s disease
Mielke, R., Schröder, R., Fink, G. R., Kessler, J., Herholz, K., & Heiß, W.-D. (1996) · Acta Neuropathologica · doi:10.1007/s004010050410 · Cited by 107
Subcortical Metabolic Alterations in Partial Epilepsy
Sperling, M. R., Gur, R. C., Alavi, A., Gur, R. E., Resnick, S. M., O’Connor, M. J., & Reivich, M. (1990) · Epilepsia · doi:10.1111/j.1528-1167.1990.tb06299.x · Cited by 107
Self-citation
Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts
Wise, R. J. S., Rhodes, C. G., Gibbs, J. M., Hatazawa, J., Palmer, T., Frackowiak, R. S. J., & Jones, T. (1983) · Annals of Neurology · doi:10.1002/ana.410140605 · Cited by 107
The local regulation of cerebral blood flow
Berne, R. M., Winn, H. R., & Rubio, R. (1981) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(81)90030-x · Cited by 107
Positron emission tomography with fluorodeoxyglucose to evaluate tumor response and control after radiation therapy
Chaiken, L. M., Rege, S., Hoh, C. K., Choi, Y. H., Jabour, B. A., Juillard, G. J. F., Hawkins, R. A., & Parker, R. (1993) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(93)90259-x · Cited by 107
Alteration of sensory-evoked metabolic and oscillatory activities in the olfactory bulb of GLAST-deficient mice
Martin, C., Houitte, D., Guillermier, M., Petit, F., Bonvento, G., & Gurden, H. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00001 · Cited by 106
Brain energy metabolism: A roadmap for future research
Rae, C. D., Baur, J. A., Borges, K., Dienel, G. A., Díaz‐García, C. M., Douglass, S. R., Drew, K. L., Duarte, J. M. N., Durán, J., Kann, O., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16032 · Cited by 113
Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory
Tadi, M., Allaman, I., Lengacher, S., Grenningloh, G., & Magistretti, P. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141568 · Cited by 109
Distribution of Glut1 Glucose Transporters in Different Brain Structures Compared to Glucose Utilization and Capillary Density of Adult Rat Brains
Zeller, K., Rahner-Welsch, S., & Kuschinsky, W. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199702000-00010 · Cited by 106
Study of direct and indirect parametric estimation methods of linear models in dynamic positron emission tomography
Tsoumpas, C., Turkheimer, F., & Thielemans, K. (2008) · Medical Physics · doi:10.1118/1.2885369 · Cited by 106
Functional mapping of limbic seizures originating in the hippocampus: a combined 2-deoxyglucose and electrophysiologic study
Lothman, E. W., Hatlelid, J. M., & Zorumski, C. F. (1985) · Brain Research · doi:10.1016/0006-8993(85)91224-7 · Cited by 106
Regional enzyme development in rat brain. Enzymes associated with glucose utilization
Leong, S. F., & Clark, J. B. (1984) · Biochemical Journal · doi:10.1042/bj2180131 · Cited by 106
Spatial patterns of spinal cord [14C]-2-deoxyglucose metabolic activity in a rat model of painful peripheral mononeuropathy
Mao, J., Price, D. D., Coghill, R. C., Mayer, D. J., & Hayes, R. L. (1992) · Pain · doi:10.1016/0304-3959(92)90116-s · Cited by 106
Metabolic activity of the basal ganglia in parkinsonian syndromes in human and non-human primates: A cytochrome oxidase histochemistry study
Vila, M., Lévy, R., Herrero, M. T., Faucheux, B. A., Obeso, J. A., Agid, Y., & Hirsch, É. C. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00549-8 · Cited by 106
Redox proteomics and amyloid β-peptide: Insights into Alzheimer disease
Butterfield, D. A., & Boyd‐Kimball, D. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14589 · Cited by 105
Qualitative and quantitative mass spectrometry imaging of drugs and metabolites
Lietz, C. B., Gemperline, E., & Li, L. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.04.009 · Cited by 105
Pulmonary Fibrosis Correlates with Duration of Tissue Neutrophil Activation
Jones, H. A., Schofield, J. B., Krausz, T. N., Boobis, A. R., & Haslett, C. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.2.9711075 · Cited by 107
Effects of Ketamine, MK-801, and Amphetamine on Regional Brain 2-Deoxyglucose Uptake in Freely Moving Mice
Miyamoto, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00127-x · Cited by 105
Cerebral Metabolic Response to Traumatic Brain Injury Sustained Early in Development: A 2-Deoxy-D-Glucose Autoradiographic Study
Thomas, S., Prins, M. L., Samii, M., & Hovda, D. A. (2000) · Journal of Neurotrauma · doi:10.1089/089771500415409 · Cited by 105
Dose–response study of caffeine effects on cerebral functional activity with a specific focus on dependence
Nehlig, A., & Boyet, S. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02480-4 · Cited by 106

Authors: Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M.
Affiliations: National Institutes of Health (US)
University of Pennsylvania (US)
National Institute of Mental Health (US)
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 1977-05
Volume: 28
Issue: 5
Pages: 897-916
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.1977.tb10649.x
OpenAlex: W2090306035
Cited by: 6,000
References: 36
Citations by year: 2026: 22 · 2025: 37 · 2024: 45 · 2023: 44 · 2022: 64 · 2021: 60 · 2020: 78 · 2019: 63 · 2018: 70 · 2017: 67 · 2016: 73 · 2015: 68 · 2014: 97 · 2013: 95 · 2012: 101
FWCI: 22.51
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10748 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: local cerebral glucose utilization, 14C-deoxyglucose, hexokinase, autoradiography, auditory cortex, medial geniculate body, superior olive, inferior colliculus, thiopental anesthesia, conscious rats, brain energy metabolism, regional cerebral blood flow
MeSH terms: Anesthesia, Animals, Antipyrine, Autoradiography, Blood Glucose, Brain, Deoxy Sugars, Deoxyglucose, Glucose, Hexokinase, Kinetics, Male, Mathematics, Methylglucosides, Models, Biological, Thiopental, Rats

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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

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