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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. Des, Patlak, C. S., Pettigrew, K. D., Sakurada, O., Shinohara, M.·1977·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.1977.tb10649.x

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Abstract

Abstract— A method has been developed for the simultaneous measurement of the rates of glucose consumption in the various structural and functional components of the brain in vivo. The method can be applied to most laboratory animals in the conscious state. It is based on the use of 2‐deoxy‐D‐[ 14 C]glucose ([ 14 C]DG) as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues. [ 14 C]DG is used because the label in its product, [ 14 C]deoxyglucose‐6‐phosphate, is essentially trapped in the tissue over the time course of the measurement. A model has been designed based on the assumptions of a steady state for glucose consumption, a first order equilibration of the free [ 14 C]DG pool in the tissue with the plasma level, and relative rates of phosphorylation of [ 14 C]DG and glucose determined by their relative concentrations in the precursor pools and their respective kinetic constants for the hexokinase reaction. An operational equation based on this model has been derived in terms of determinable variables. A pulse of [ 14 C]DG is administered intravenously and the arterial plasma [ 14 C]DG and glucose concentrations monitored for a preset time between 30 and 45min. At the prescribed time, the head is removed and frozen in liquid N 2 ‐chilled Freon XII, and the brain sectioned for autoradiography. Local tissue concentrations of [ 14 C]DG are determined by quantitative autoradiography. Local cerebral glucose consumpt…

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Authors: Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M.
Affiliations: National Institutes of Health (US)
University of Pennsylvania (US)
National Institute of Mental Health (US)
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 1977-05
Volume: 28
Issue: 5
Pages: 897-916
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.1977.tb10649.x
OpenAlex: W2090306035
Cited by: 6,000
References: 36
Citations by year: 2026: 22 · 2025: 37 · 2024: 45 · 2023: 44 · 2022: 64 · 2021: 60 · 2020: 78 · 2019: 63 · 2018: 70 · 2017: 67 · 2016: 73 · 2015: 68 · 2014: 97 · 2013: 95 · 2012: 101
FWCI: 22.51
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10748 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: local cerebral glucose utilization, 14C-deoxyglucose, hexokinase, autoradiography, auditory cortex, medial geniculate body, superior olive, inferior colliculus, thiopental anesthesia, conscious rats, brain energy metabolism, regional cerebral blood flow
MeSH terms: Anesthesia, Animals, Antipyrine, Autoradiography, Blood Glucose, Brain, Deoxy Sugars, Deoxyglucose, Glucose, Hexokinase, Kinetics, Male, Mathematics, Methylglucosides, Models, Biological, Thiopental, Rats

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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

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