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Cited by 6,000Neuroscience and Neuropharmacology ResearchMedical Imaging Techniques and ApplicationsAdvanced MRI Techniques and Applications

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. Des, Patlak, C. S., Pettigrew, K. D., Sakurada, O., Shinohara, M.·1977·Journal of Neurochemistry
DOI 10.1111/j.1471-4159.1977.tb10649.x
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Abstract

Abstract— A method has been developed for the simultaneous measurement of the rates of glucose consumption in the various structural and functional components of the brain in vivo. The method can be applied to most laboratory animals in the conscious state. It is based on the use of 2‐deoxy‐D‐[ 14 C]glucose ([ 14 C]DG) as a tracer for the exchange of glucose between plasma and brain and its phosphorylation by hexokinase in the tissues. [ 14 C]DG is used because the label in its product, [ 14 C]deoxyglucose‐6‐phosphate, is essentially trapped in the tissue over the time course of the measurement. A model has been designed based on the assumptions of a steady state for glucose consumption, a first order equilibration of the free [ 14 C]DG pool in the tissue with the plasma level, and relative rates of phosphorylation of [ 14 C]DG and glucose determined by their relative concentrations in the precursor pools and their respective kinetic constants for the hexokinase reaction. An operational equation based on this model has been derived in terms of determinable variables. A pulse of [ 14 C]DG is administered intravenously and the arterial plasma [ 14 C]DG and glucose concentrations monitored for a preset time between 30 and 45min. At the prescribed time, the head is removed and frozen in liquid N 2 ‐chilled Freon XII, and the brain sectioned for autoradiography. Local tissue concentrations of [ 14 C]DG are determined by quantitative autoradiography. Local cerebral glucose consumpt…

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Crossref · 10.1111/j.1471-4159.1977.tb10649.x

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Research works printed but not linked: 13

  1. Rosiers M. H., 1974, Neurology, 24, 389
  2. Dixon M., 1964, Enzymes, 84
  3. Hers H. G., 1950, Bull. Soc. chem. Biol., 32, 20
  4. Kennedy C., 1974, Trans. Am. Soc. Neurochem., 5, 86
  5. Kety S. S., 1960, Meth. Med. Res., 8, 228
  6. KnottG. D.&ReeceD. K.(1972) inProc. ONLINE ′72 International Conference Vol. 1 pp.497–526. Brunel University England.
  7. Landau W. H., 1955, Trans. Am. Neurol. Ass., 80, 125
  8. Plum F., 1976, Neurosci. Res. Prog. Bull., 14, 457
  9. Saifer A., 1958, J. Lab. Clin. Med., 51, 448
  10. Sokoloff L., 1960, Handbook of Physiology‐Neurophysiology, 1843
  11. Sokoloff L., 1969, Psychochemical Research in Man, 237
  12. Sokoloff L., 1974, Trans. Am. Soc. Neurochem., 5, 85
  13. Sokoloff L., 1976, Basic Neurochemistry, 388

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Metadata

Authors
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M.
Affiliations
  • National Institutes of Health (US)
  • University of Pennsylvania (US)
  • National Institute of Mental Health (US)
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
1977-05
Volume
28
Issue
5
Pages
897-916
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
DOI
10.1111/j.1471-4159.1977.tb10649.x
OpenAlex
W2090306035
Cited by
6,000
References
36
Citations by year
2026: 22 · 2025: 37 · 2024: 45 · 2023: 44 · 2022: 64 · 2021: 60 · 2020: 78 · 2019: 63 · 2018: 70 · 2017: 67 · 2016: 73 · 2015: 68 · 2014: 97 · 2013: 95 · 2012: 101
FWCI
22.51
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10748 d)
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
local cerebral glucose utilization, 14C-deoxyglucose, hexokinase, autoradiography, auditory cortex, medial geniculate body, superior olive, inferior colliculus, thiopental anesthesia, conscious rats, brain energy metabolism, regional cerebral blood flow
MeSH terms
Anesthesia, Animals, Antipyrine, Autoradiography, Blood Glucose, Brain, Deoxy Sugars, Deoxyglucose, Glucose, Hexokinase, Kinetics, Male, Mathematics, Methylglucosides, Models, Biological, Thiopental, Rats

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