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A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade
Open accessAbstract
Accumulating evidence points to an important role of intraneuronal Aβ as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's disease (AD) with its typical clinical symptoms, like memory impairment and change in personality. In the present article, we review recent findings on intracellular monomeric and oligomeric β‐amyloid (Aβ) generation and its pathological function in cell culture, transgenic AD mouse models and post mortem brain tissue of AD and Down syndrome patients, as well as its interaction with oxidative stress and its relevance in apoptotic cell death. Based on these results, a modified Aβ hypothesis is formulated, that integrates biochemical, neuropathological and genetic observations with AD‐typical neuron loss and plaque formation.
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506
Amyloid deposition as the central event in the aetiology of Alzheimer’s disease
Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380
Life and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123
Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., & Klein, W. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834302100 · Cited by 1,061
Research works printed but not linked: 47
- 10.1038/ncb1101-1030 · DOI
- 10.1002/(SICI)1096-9861(19980720)397:1<139::AID-CNE10>3.0.CO;2-K · DOI
- 10.1111/j.1750-3639.2001.tb00376.x · DOI · Paper page
- 10.1038/sj.leu.2400699 · doi:10.1038/sj.leu.2400699
- 10.1016/S0014-4886(03)00252-8 · DOI · Paper page
- 10.1016/S0006-8993(96)01262-0 · DOI · Paper page
- 10.1016/S0896-6273(02)00604-9 · DOI · Paper page
- 10.3233/JAD-2001-3208 · DOI
- 10.1038/nm0997-1021 · DOI · Paper page
- 10.1016/S0304-3940(02)00875-3 · DOI · Paper page
- 10.1006/nbdi.2000.0364 · DOI · Paper page
- Fernandez‐Vizarra P., 2004, Intra‐ and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease, Histol. Histopathol., 19, 823
- 10.1016/S0006-291X(84)80190-4 · DOI · Paper page
- 10.1074/jbc.M210380200 · DOI
- 10.1038/ncb0702-e164b · DOI
- 10.1038/nm0997-1016 · DOI · Paper page
- 10.1038/nm0198-097 · DOI · Paper page
- 10.1016/0014-5793(96)00948-9 · DOI
- 10.1111/j.1582-4934.2001.tb00134.x · DOI
- 10.1523/JNEUROSCI.5543-03.2004 · DOI · Paper page
- 10.1073/pnas.89.16.7437 · DOI · Paper page
- 10.1172/JCI119536 · DOI
- 10.1074/jbc.270.45.26727 · DOI
- Masters C. L., 1985, Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels, EMBO J, 11, 2757, 10.1002/j.1460-2075.1985.tb04000.x · DOI · Paper page
- 10.1074/jbc.274.10.6483 · DOI · Paper page
- 10.1159/000017110 · DOI
- 10.1038/ncb0702-e164a · DOI
- 10.1097/00001756-200001170-00033 · DOI
- 10.1006/bbrc.2000.2164 · DOI
- 10.1016/j.neulet.2003.11.068 · DOI
- 10.1021/bi0267590 · DOI
- 10.1074/jbc.M303547200 · DOI
- 10.1006/exnr.1999.7307 · DOI
- 10.1097/00001756-200301200-00023 · DOI · Paper page
- 10.1046/j.1471-4159.1998.71041535.x · DOI
- 10.1016/S0197-4580(01)00265-2 · DOI
- 10.1126/science.8191290 · DOI · Paper page
- 10.1016/S0002-9440(10)64463-X · DOI · Paper page
- 10.1111/j.0953-816X.2003.03135.x · DOI
- 10.1074/jbc.271.15.8966 · DOI · Paper page
- 10.1021/bi001048s · DOI · Paper page
- 10.1042/bst0300552 · DOI · Paper page
- 10.1073/pnas.90.20.9513 · DOI · Paper page
- 10.1038/nn898 · DOI
- 10.1016/S0304-3940(01)01876-6 · DOI · Paper page
- 10.1073/pnas.94.8.3748 · DOI · Paper page
- 10.1002/(SICI)1097-4547(19980615)52:6<691::AID-JNR8>3.0.CO;2-3 · doi:10.1002/(sici)1097-4547(19980615)52:6<691::aid-jnr8>3.0.co;2-3
Cited by
Hansson Petersen, C. A., Alikhani, N., Behbahani, H., Wiehager, B., Pavlov, P. F., Alafuzoff, I., Leinonen, V., Ito, A., Winblad, B., Glaser, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806192105 · Cited by 693
Kawahara, M., & Kato-Negishi, M. (2011) · International Journal of Alzheimer’s Disease · doi:10.4061/2011/276393 · Cited by 509
Alzheimer disease models and human neuropathology: similarities and differences
Duyckaerts, C., Potier, M.-C., & Delatour, B. (2008) · Acta Neuropathologica · doi:10.1007/s00401-007-0312-8 · Cited by 375
Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease
Gouras, G. K., Tampellini, D., Takahashi, R. H., & Capetillo-Zarate, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0679-9 · Cited by 372
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
Gouras, G. K., Almeida, C. G., & Takahashi, R. H. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.022 · Cited by 338
Metadata
- Authors
- Wirths, O., Multhaup, G., & Bayer, T. A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2004-09-07
- Volume
- 91
- Issue
- 3
- Pages
- 513-520
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2016436495
- Cited by
- 350
- References
- 28
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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