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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Consistent immunohistochemical detection of intracellular β-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex

D'Andrea, Michael R., Nagele, Robert G., Wang, Hoau-Yan, Lee, Daniel H.S.·2002·Neuroscience Letters
DOI 10.1016/s0304-3940(02)00875-3
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Abstract

We compared the effects of three pretreatment immunohistochemical techniques (no pretreatment, pepsin predigestion and heat pretreatment (HEAT)) for detecting intracellular beta-amyloid42 (Abeta42) in pyramidal neurons of formalin-fixed Alzheimer's disease (AD) cortices (n = 25). Although all three protocols immunostained Abeta42 in amyloid plaques using four commercially-obtained Abeta42 specific antibodies, only the HEAT protocol consistently detected prominent intracellular Abeta42 in pyramidal neurons. This suggests that the Abeta42 present in amyloid plaques may be structurally distinct from that located within the neurons perhaps due to differential binding proteins coupling or a consequence of formalin fixation. Detection of an abundant intracellular Abeta42 in neurons may provide alternate explanations for the origin of dense-core amyloid plaques in AD cortices other than the conventional chronic extracellular Abeta42 deposition hypothesis.

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Crossref · 10.1016/s0304-3940(02)00875-3

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4 of 4 references verified0 citation errors · 0 not checkable

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  • Intracellular accumulation of Aβ-(1-42) results from one or a combination of decreased Aβ degradation, increased intracellular generation of Aβ, and increased uptake of Aβ from an external source.

    “Intracellular accumulation of A␤-(1-42) results from one or a combination of the following processes: decreased A␤ degradation (disruption of the ubiquitin-proteasome system), increased intracellular generation of A␤, and increased uptake of A␤ from an external source (11).”

    From Internalization of β-Amyloid Peptide by Primary Neurons in the Absence of Apolipoprotein E (2007) · cites this paper as [11]

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Research works printed but not linked: 14

  1. Bence, 2001, Impairment of the ubiquitin-proteasome system by protein aggregation, Science, 292, 1552, 10.1126/science.292.5521.1552 · DOI
  2. D'Andrea, 2002, MAP-2 immunolabeling can distinguish diffuse from dense-core amyloid plaques in Alzheimer's disease brains, Biotec. Histochem., 77:2, 95, 10.1080/714028180 · DOI
  3. D'Andrea, 2002, Lipofuscin and Aβ42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains, Neurosci. Lett., 323, 45, 10.1016/S0304-3940(01)02444-2 · DOI
  4. D'Andrea, 2001, Application of triple-label immunohistochemistry to characterize inflammation in Alzheimer's disease brains, Biotec. Histochem., 76, 97, 10.1080/bih.76.2.97.106 · DOI
  5. Iwata, 2000, Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition, Nat. Med., 6, 143, 10.1038/77399 · DOI
  6. Iwata, 2001, Metabolic regulation of brain Aβ by neprilysin, Science, 292, 1550, 10.1126/science.1059946 · DOI
  7. Kraszpulski, 1998, Pitfalls in the quantitative estimation of β-amyloid immunoreactivity in human brain tissue, Histochem. Cell Biol., 110, 439, 10.1007/s004180050305 · DOI
  8. Levy, 2001, Codeposition of cystatin C with amyloid-β protein in the brain of Alzheimer disease patients, J. Neuropathol. Exp. Neurol., 60, 94, 10.1093/jnen/60.1.94 · DOI
  9. Nagele, 2002, Accumulation of beta-amyloid1-42 in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease, Neuroscience, 110, 199, 10.1016/S0306-4522(01)00460-2 · DOI
  10. Shi, 1997, Antigen retrieval immunohistochemistry: past, present, and future, J. Histochem. Cytochem., 54, 327, 10.1177/002215549704500301 · DOI
  11. Sparks, 1996, Intraneuronal β-amyloid immunoreactivity in the CNS, Neurobiol. Aging, 17, 291, 10.1016/0197-4580(95)02067-5 · DOI
  12. Taylor, 1994, Hum. Pathol., 25, 263, 10.1016/0046-8177(94)90198-8 · DOI
  13. Wang, 2000, β-amyloid1-42 binds to α7 nicotinic acetylcholine receptor with high affinity: implications for Alzheimer's disease pathology, J. Biol. Chem., 275, 5626, 10.1074/jbc.275.8.5626 · DOI
  14. Wirths, 2001, Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice, Neurosci. Lett., 306, 116, 10.1016/S0304-3940(01)01876-6 · DOI · Paper page

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Metadata

Authors
D'Andrea, M. R., Nagele, R. G., Wang, H.-Y., & Lee, D. H. S.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2002-11
Volume
333
Issue
3
Pages
163-166
ISSN
0304-3940
DOI
10.1016/s0304-3940(02)00875-3
Cited by
64
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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