Spatio‐temporal activation of cyclic AMP response element‐binding protein, activity‐regulated cytoskeletal‐associated protein and brain‐derived nerve growth factor: a mechanism for pontine‐wave generator activation‐dependent two‐way active‐avoidance memory processing in the rat
Abstract
The present study explored possible physiological and molecular mechanisms of pontine-wave (P-wave) generator activation-dependent memory processing in the rat using a two-way active-avoidance learning paradigm. The results show that learning training increased rapid eye movement sleep and activated brainstem cells in the P-wave generator. During this period, there was a time-dependent increase in phosphorylation of cAMP response element-binding protein (CREB) in the dorsal hippocampus and amygdala and increased synthesis of activity-regulated cytoskeletal-associated protein (Arc) in the dorsal hippocampus, amygdala, frontal cortex and occipital cortex. Learning training also increased synthesis of brain-derived nerve growth factor (BDNF) in the occipital cortex, amygdala and dorsal hippocampus at different time intervals. During this time, the levels of nerve growth factor did not change. The results also show that the increase in rapid eye movement sleep P-wave density during the post-training 3-h recording session is positively correlated with the increased levels of phosphorylated CREB, BDNF and Arc in the dorsal hippocampus. These results suggest that memory processing of two-way active-avoidance learning may involve excitation of P-wave-generating cells in the brainstem and increased expression of phosphorylated CREB, Arc and BDNF in a time-dependent manner in the forebrain. These dynamic changes in cellular and molecular features provide considerable insight into the m…
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PGO wave density during posttraining REM sleep is correlated with increased activity of plasticity-related immediate early genes and brain-derived neurotrophic factors in the dorsal hippocampus.
“Moreover, PGO wave density during posttraining REM sleep is correlated with increased activity of plasticity-related immediate early genes and brain-derived neurotrophic factors in the dorsal hippocampus.”
From About Sleep's Role in Memory (2013) · cites this paper as [1225]
Training on an active avoidance task is followed by a robust increase in PGO wave density for 3-4 h after training, and changes in PGO wave density were also proportional to the improvement in task performance between initial training and post-sleep retest.
“Training on an active avoidance task is followed by a robust increase in PGO wave density for 3-4 h after training, and changes in PGO wave density were also proportional to the improvement in task performance between initial training and post-sleep retest (259, 261, 1225).”
From About Sleep's Role in Memory (2013) · cites this paper as [1225]
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- Authors
- Ulloor, J., & Datta, S.
- Affiliations
- Boston University (US)
- Corresponding author
- Datta, Subimal
- ORCID
- Datta, Subimal
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2005-09-12
- Volume
- 95
- Issue
- 2
- Pages
- 418-428
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1998738411
- Cited by
- 89
- References
- 7
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 8 · 2017: 9 · 2015: 9 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- National Institute of Mental Health (MH 59839, R01MH059839)
- National Institute of Neurological Disorders and Stroke (NS-34004)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- P wave, memory consolidation, CREB phosphorylation, Arc, REM sleep, dorsal hippocampus, amygdala, brainstem
- MeSH terms
- Amygdala, Animals, Avoidance Learning, Cerebral Cortex, Cytoskeletal Proteins, Electrodes, Implanted, Electroencephalography, Electrooculography, Enzyme-Linked Immunosorbent Assay, Hippocampus, Male, Memory, Nerve Tissue Proteins, Phosphorylation, Pons, Sleep, REM, Blotting, Western, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Immediate-Early Proteins, Brain-Derived Neurotrophic Factor, Nerve Growth Factor, Rats
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