Phase-locking of spontaneous and tone-elicited pontine waves to hippocampal theta waves during REM sleep in rats
Abstract
Temporal relationships between hippocampal theta waves and pontine waves (P waves) during rapid-eye-movement (REM) sleep were investigated in rats. P waves were phase-locked to the positive theta peak. The phase relationships of P waves elicited by a tone stimulus (P(E) waves) to hippocampal theta waves were also analyzed to qualitatively clarify the mechanism of phase-locking between these two phenomena. P(E) waves occurred at the positive theta peak, as seen for spontaneous P waves. This phase preference of P(E) waves could be understood as that of the response probability to tone stimulus. These data suggest that the P-wave generator receives inputs that mimic theta waves. As hippocampal theta waves and P waves are known to be involved in learning and memory processes during REM sleep, the present studies could help to clarify these functions.
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Theta activity, i.e., periods of synchronized activity in the 4-8 Hz frequency band, is a hallmark of tonic REM sleep and correlates with rapid eye movements and PGO waves.
“Theta activity, i.e., periods of synchronized activity in the 4 -8 Hz frequency band, is a hallmark of tonic REM sleep (REM sleep without actual rapid eye movements) (161) and correlates with rapid eye movements and PGO waves (618 -620).”
From About Sleep's Role in Memory (2013) · cites this paper as [618]
PGO waves tend to occur phase-locked to theta oscillations.
“PGO waves tend to occur phase-locked to theta oscillations (618).”
From About Sleep's Role in Memory (2013) · cites this paper as [618]
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“PGO waves tend to occur phase-locked to theta oscillations (618).”
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- Authors
- Karashima, A., Katayama, N., & Nakao, M.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Karashima, Akihiro
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 1182
- Pages
- 73-81
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2067562916
- Cited by
- 20
- References
- 48
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- REM sleep, phase locking, rats
- MeSH terms
- Acoustic Stimulation, Animals, Hippocampus, Models, Biological, Pons, Probability, Reaction Time, Sleep, REM, Theta Rhythm, Rats, Sprague-Dawley, Rats
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