Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague‐Dawley rats
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J. Neurochem.(2010)114, 666–674. Adipocytes produce the hormone, leptin, in proportion to fat mass to signal the status of body energy stores to the central nervous system, thereby modulating food intake and energy homeostasis. In addition to controlling satiety, leptin suppresses the reward value of food, which is controlled by the mesolimbic dopamine (DA) system. Previous results from leptin‐deficient ob/ob animals suggest that chronic leptin deficiency decreases DA content in the mesolimbic DA system, thereby decreasing the response to amphetamine (AMPH). The extent to which these alterations in the mesolimbic DA system of ob/ob animals may mirror the leptin response of normal animals has remained unclear, however. We therefore examined the potential short‐term modulation of the mesolimbic DA system by leptin in normal animals. We show that 4 h of systemic leptin treatment enhances AMPH‐stimulated DA efflux in the nucleus accumbens (NAc) of Sprague‐Dawley rats. While acute leptin treatment increased NAc tyrosine hydroxylase activity, total tyrosine hydroxylase and DA content were unchanged at this early time point. Leptin also increased NAc DA transporter activity in the absence of changes in cell surface or total DA transporter. Thus, leptin modulates the mesolimbic DA system via multiple acute mechanisms, and increases AMPH‐mediated DA efflux in normal animals.
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In normal rats, leptin promotes tyrosine hydroxylase activity and amphetamine-mediated dopamine efflux in the nucleus accumbens.
“Also, in normal rats, leptin promotes tyrosine hydroxylase activity and amphetamine-mediated dopamine efflux in the nucleus accumbens”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [124]
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Food reward, hyperphagia, and obesity
Berthoud, H.-R., Lenard, N. R., & Shin, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2011 · Cited by 275 · see citing works
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“They also diminish the sensitivity of DA pathways to food reward (2), whichmay reflect the ability of insulin (8) and leptin (9) to enhance removal of DA from the synaptic cleft by the DA transporter.”
BackgroundLiu, J., Perez, S. M., Zhang, W., Lodge, D. J., & Lu, X.-Y. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.36 · Cited by 118 · see citing works
- Authors
- Perry, M. L., Leinninger, G. M., Chen, R., Luderman, K. D., Yang, H., Gnegy, M. E., Myers, M. G., & Kennedy, R. T.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Kennedy, Robert T.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2010-07-06
- Volume
- 114
- Issue
- 3
- Pages
- 666-674
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- PMC
- PMC2910163
- OpenAlex
- W1612489662
- Cited by
- 47
- References
- 39
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 4 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institute on Drug Abuse (DA025954, T32DA007267, R03DA025954)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078056, P30DK020572)
- National Institute of Biomedical Imaging and Bioengineering (R37EB003320)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- leptin, dopamine transporter, tyrosine hydroxylase, nucleus accumbens, mesolimbic dopamine system, food reward, energy homeostasis, ob/ob mice
- MeSH terms
- Amphetamine, Animals, Appetite, Appetite Regulation, Dopamine, Male, Neurons, Nucleus Accumbens, Reward, Tyrosine 3-Monooxygenase, Rats, Sprague-Dawley, Dopamine Uptake Inhibitors, Leptin, Dopamine Plasma Membrane Transport Proteins, Rats
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