The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
Open accessAbstract
Summary: Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators such as the cap‐binding complex and S6 kinase play an important role during growth. We observe that inhibition of various genes in the translation initiation complex including ifg‐1, the worm homologue of eIF4G, which is a scaffold protein in the cap‐binding complex; and rsks‐1, the worm homologue of S6 kinase, results in lifespan extension in Caenorhabditis elegans. Inhibition of ifg‐1 or rsks‐1 also slows development, reduces fecundity and increases resistance to starvation. A reduction in ifg‐1 expression in dauers was also observed, suggesting an inhibition of protein translation during the dauer state. Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans.
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Cites
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Cited by
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
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“Studies in the nematode Caenorhabditis elegans demonstrated that inhibition of several components of the eIF4F complex including eIF4E and eIF4G or lowering their levels extends life span (Pan et al., 2007; Syntichaki et al., 2007; Curran and Ruvkun, 2007; Hansen et al., 2007; Henderson et al., 2006).”
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mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676
The proteostasis network and its decline in ageing
Hipp, M. S., Kasturi, P., & Hartl, F. U. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0101-y · Cited by 1,642
Metadata
- Authors
- Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J., & Kapahi, P.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2006-12-05
- Volume
- 6
- Issue
- 1
- Pages
- 111-119
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W2086691574
- Cited by
- 498
- References
- 47
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J., & Kapahi, P. (2007). Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell. https://doi.org/10.1111/j.1474-9726.2006.00266.x
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