The dynamin‐related protein DRP‐1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity
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Summary: Here, we report that inactivation of the Caenorhabditis elegans dynamin‐related protein DRP‐1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.
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This is the first report establishing a direct connection between a protein involved in mitochondrial dynamics and aging in mammals.
“to our knowledge, this is the first report establishing a direct connection between a protein involved in mitochondrial dynamics and aging in mammals.”
From Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway (2016) · cites this paper as Yang et al, 2011
The Abstract reports the first beneficial effect of manipulating mitochondrial dynamics on lifespan in an animal, specifically C. elegans. It says the findings are likely relevant to mammals, but does not establish a direct connection with aging in mammals. (LLM, conf=0.90)
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- Authors
- Yang, C. C., Chen, D., Lee, S. S., & Walter, L.
- Affiliations
- Cornell University (US)
- Corresponding author
- Lee, Siu Sylvia
- Walter, Ludivine
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2011-04-25
- Volume
- 10
- Issue
- 4
- Pages
- 724-728
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC3135752
- OpenAlex
- W1514640681
- Cited by
- 61
- References
- 29
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 7 · 2012: 6
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG024425, R56AG024425)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- Drp1, dynamin-related proteins, insulin signaling, lifespan extension, aging, mitochondrial fission, mitochondrial dynamics, mitochondrial morphology, Caenorhabditis elegans
- MeSH terms
- Animals, Insulin, Longevity, Phenotype, Signal Transduction, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Dynamins
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