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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

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Efficacy of berberine in patients with type 2 diabetes mellitus

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Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

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Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

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Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

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Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

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Berberine improves glucose metabolism through induction of glycolysis

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Anti-cancer natural products isolated from chinese medicinal herbs

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Traditional Chinese Medicine in Treatment of Metabolic Syndrome

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Hepatocyte Nuclear Factor 1α Plays a Critical Role in PCSK9 Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

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Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine

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An update on regional variation in cardiovascular mortality within Europe

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Cardiovascular actions of berberine

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Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARγ pathway

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Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression

Kong, W., Zhang, H., Song, D., Xue, R., Zhao, W., Wei, J., Wang, Y., Shan, N., Zhou, Z., Yang, P., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2008.08.013 · Cited by 266 · see citing works

Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic Gluconeogenesis

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Berberine: Therapeutic Potential of an Alkaloid Found in Several Medicinal Plants

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Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK

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Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion.

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Effects of berberine on glucose metabolism in vitro

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Berberine decreases PCSK9 expression in HepG2 cells

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Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats

Zhou, J., Zhou, S., Tang, J., Zhang, K., Guang, L.-X., Huang, Y., Xu, Y. X., Ying, Y., Zhang, L., & Li, D. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.12.056 · Cited by 208 · see citing works

Berberine Modifies Cysteine 179 of IκBα Kinase, Suppresses Nuclear Factor-κB–Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

Pandey, M. K., Sung, B., Kunnumakkara, A. B., Sethi, G., Chaturvedi, M. M., & Aggarwal, B. B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0511 · Cited by 201 · see citing works

Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

Zeng, X., Zeng, X., & Li, Y.-Y. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00533-2 · Cited by 192 · see citing works

Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics

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Berberine stimulates glucose transport through a mechanism distinct from insulin

Zhou, L., Yang, Y., Wang, X., Liu, S., Shang, W., Yuan, G., Li, F., Tang, J., Chen, M., & Chen, J. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.025 · Cited by 187 · see citing works

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice

Xie, W., Gu, D., Li, J., Cui, K., & Zhang, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024520 · Cited by 183 · see citing works

Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma

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Extracellular Signal-Regulated Kinase–Dependent Stabilization of Hepatic Low-Density Lipoprotein Receptor mRNA by Herbal Medicine Berberine

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Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte

Choi, B.-H., Ahn, I., Kim, Y., Park, J.-W., Lee, S. Y., Hyun, C., & Do, M. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.71 · Cited by 166 · see citing works

Combination of simvastatin with berberine improves the lipid-lowering efficacy

Kong, W., Wei, J., Zuo, Z.-Y., Wang, Y., Song, D., You, X., Zhao, L., Pan, H.-N., & Jiang, J. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.037 · Cited by 162 · see citing works

HEPATOBILIARY EXCRETION OF BERBERINE

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Chronic Effects of Berberine on Blood, Liver Glucolipid Metabolism and Liver PPARs Expression in Diabetic Hyperlipidemic Rats

Zhou, J. Y., Zhou, S. W., Zhang, K. B., Tang, J., Guang, L. X., Ying, Y., Xu, Y. X., Zhang, L., & Li, D. D. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1169 · Cited by 156 · see citing works

Modulating gut microbiota as an anti-diabetic mechanism of berberine

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Inhibitory effect of berberine on tert -butyl hydroperoxide-induced oxidative damage in rat liver

Hwang, J.-M., Wang, C., Chou, F.-P., Tseng, T., Hsieh, Y., Lin, W., & Chu, C.-Y. (2002) · Archives of Toxicology · doi:10.1007/s00204-002-0351-9 · Cited by 140 · see citing works

Berberine Activates GLUT1-Mediated Glucose Uptake in 3T3-L1 Adipocytes

Kim, S. H., Shin, E.-J., Kim, E.-D., Bayaraa, T., Frost, S. C., & Hyun, C. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.2120 · Cited by 136 · see citing works

Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study

Affuso, F., Ruvolo, A., Micillo, F., Saccà, L., & Fazio, S. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.05.017 · Cited by 135 · see citing works

Cardiovascular effects of berberine in patients with severe congestive heart failure

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Vasorelaxant and antiproliferative effects of berberine

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Eulipidemic Effects of Berberine Administered Alone or in Combination with Other Natural Cholesterol-lowering Agents

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Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes

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Berberine promotes glucagon-like peptide-1 (7–36) amide secretion in streptozotocin-induced diabetic rats

Lu, S.-S., Yu, Y.-L., Zhu, H., Liu, X., Liu, L., Liu, Y.-W., Wang, P., Xie, L. Y., & Wang, G.-J. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0419 · Cited by 111 · see citing works

The antihypertensive and vasodilator effects of aqueous extract fromBerberis vulgaris fruit on hypertensive rats

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Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans

Cheng, F., Wang, Y., Li, J., Su, C., Wu, F., Xia, W., Yang, Z., Yu, B., Qiu, Y., & Tao, J. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.090 · Cited by 108 · see citing works

Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus

Zhang, W., Yan-cheng, X. U., Fang-jian, G. U. O., Ye, M., & Li, M. (2008) · Chinese Medical Journal · doi:10.1097/00029330-200811010-00003 · Cited by 107 · see citing works

Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase

Liu, W., Hei, Z., Nie, H., Tang, F., Huang, H., Li, X., Yan-hui, D. E. N. G., Chen, S., Guo, F., Huang, W., et al. (2008) · Chinese Medical Journal · doi:10.1097/00029330-200804020-00009 · Cited by 106 · see citing works

Berberine-induced LDLR up-regulation involves JNK pathway

Lee, S., Lim, H., Park, J., Lee, K., Jang, Y., & Park, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.060 · Cited by 94 · see citing works

Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements

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Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells

Liang, K., Yin, S., Ting, C.-T., Lin, S., Hsueh, C., Chen, C.-Y., & Hsu, S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.034 · Cited by 89 · see citing works

Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver

Xing, L., Zhang, L. R., Liu, T., Hua, Y., Zheng, P., & Ji, G. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.036 · Cited by 88 · see citing works

Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice

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Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice1

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A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome

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Mechanism of vasodilatory effect of berberine in rat mesenteric artery

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Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels

Kang, D. G., Sohn, E. J., Kwon, E. K., Han, J. H., Oh, H., & Lee, H. S. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(03)00005-3 · Cited by 74 · see citing works

Berberine Acutely Inhibits Insulin Secretion from β-Cells through 3′,5′-Cyclic Adenosine 5′-Monophosphate Signaling Pathway

Zhou, L., Wang, X., Shao, L., Yang, Y., Shang, W., Yuan, G., Jiang, B., Li, F., Tang, J., Hua, J., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1752 · Cited by 73 · see citing works

Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury

Liang, K., Ting, C.-T., Yin, S., Chen, Y., Lin, S., Liao, J. K., & Hsu, S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.028 · Cited by 73 · see citing works

Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study

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Berberine Inhibits the Production of Lysophosphatidylcholine-induced Reactive Oxygen Species and the ERK1/2 Pathway in Vascular Smooth Muscle Cells

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Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity

Wang, Z., Lu, F., Leng, S.-H., Fang, X., Chen, G., Wang, Z.-S., Dong, L., & Yan, Z.-Q. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6004 · Cited by 61 · see citing works

A biochemical study on the hypotensive effect of berberine in rats

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Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKβ

Yi, P. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.876 · Cited by 57 · see citing works

Effect of Berberine on Regression of Pressure-Overload Induced Cardiac Hypertrophy in Rats

Hong, Y., Hui, S.-C., Chan, T. W., & Hou, J.-Y. (2002) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x02000612 · Cited by 57 · see citing works

Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells

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Berberine-induced activation of 5′-adenosine monophosphate–activated protein kinase and glucose transport in rat skeletal muscles

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Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition

Liu, W., Tang, F., Deng, Y., Li, X., Lan, T., Zhang, X., Huang, H., & Liu, P. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-0024-y · Cited by 53 · see citing works

Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosis

Zhao, W., Xue, R., Zhou, Z., Kong, W., & Jiang, J. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.01.007 · Cited by 53 · see citing works

Targeting metabolic syndrome: Candidate natural agents

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Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway

Xie, X., Li, W., Lan, T., Liu, W., Peng, J., Huang, K., Huang, J., Shen, X., Liu, P., & Huang, H. (2011) · Endocrine Journal · doi:10.1507/endocrj.k11e-024 · Cited by 51 · see citing works

Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy

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Berberine, a natural lipid-lowering drug, exerts prothrombotic effects on vascular cells

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Berberine-induced decline in circulating CD31+/CD42− microparticles is associated with improvement of endothelial function in humans

Wang, J.-M., Yang, Z., Xu, M.-G., Chen, L., Wang, Y., Su, C., & Tao, J. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.037 · Cited by 45 · see citing works

Berberine-Induced Upregulation of Circulating Endothelial Progenitor Cells Is Related to Nitric Oxide Production in Healthy Subjects

Xu, M.-G., Wang, J., Chen, L., Wang, Y., Yang, Z., & Tao, J. (2008) · Cardiology · doi:10.1159/000157336 · Cited by 43 · see citing works

Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity

Xu, M.-G., Wang, J.-M., Chen, L., Wang, Y., Yang, Z., & Tao, J. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002311 · Cited by 37 · see citing works

[Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes].

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Inhibitory effects of berberine on ATP-sensitive K+ channels in cardiac myocytes

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Berberine: metabolic and cardiovascular effects in preclinical and clinical trials

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Mechanism of the Aortic Relaxation Induced by Low Concentrations of Berberine

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Evaluation of the alpha-adrenoceptor antagonistic action of berberine in isolated organs.

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Beneficial effects of berberine on hemodynamics during acute ischemic left ventricular failure in dogs.

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Biochemical pathways in the antiatherosclerotic effect of berberine

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Natural sources of antidyslipidaemic agents: is there an evidence-based approach for their prescription?

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Limitations of statin monotherapy for the treatment of dyslipidemia: a projection based on the Canadian lipid study – observational

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Natural sources of antidyslipidaemic agents: is there an evidence-based approach for their prescription?

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LONG-TERM EFFECTS OF A BERBERINE BASED NUTRACEUTICAL ON BODY WEIGHT AND INSULIN-SENSITIVITY IN NON DIABETIC HYPERLIPIDAEMIC PATIENTS

Cicero, A. F. G., Derosa, G., Maffioli, P., Gerocarni, B., Grandi, E., & Borghi, C. (2011) · Journal of Hypertension · doi:10.1097/00004872-201106001-00404 · Cited by 2 · see citing works

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

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Berberis Vulgaris and Berberine: An Update Review

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Berberine pharmacology and the gut microbiota: A hidden therapeutic link

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Transforming berberine into its intestine-absorbable form by the gut microbiota

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Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

Cicero, A. F. G., Colletti, A., Bajraktari, G., Descamps, O. S., Djuric, D. M., Владиславович, Е. М., Fras, Z., Katsiki, N., Langlois, M. R., Latkovskis, G., et al. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux047 · Cited by 298 · see citing works

Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

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Application of Berberine on Treating Type 2 Diabetes Mellitus

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Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion

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The roles of macrophage autophagy in atherosclerosis

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Functional foods and dietary supplements for the management of dyslipidaemia

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The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine

Ma, X., Chen, Z., Wang, L., Wang, G., Wang, Z., Dong, X., Wen, B., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00782 · Cited by 189 · see citing works

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway

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Berberine and inflammatory bowel disease: A concise review

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Role of phytochemicals in the management of metabolic syndrome

Cicero, A. F. G., & Colletti, A. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.11.009 · Cited by 151 · see citing works

Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses

Li, Y., Xiao, H., Hu, D.-D., Fatima, S., Lin, C., Mu, H., Lee, N. P. Y., & Bian, Z. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.02.010 · Cited by 143 · see citing works

Food and plant bioactives for reducing cardiometabolic disease risk: an evidence based approach

Cicero, A. F. G., Fogacci, F., & Colletti, A. (2017) · Food & Function · doi:10.1039/c7fo00178a · Cited by 142 · see citing works

Effects of Berberine in the Gastrointestinal Tract — A Review of Actions and Therapeutic Implications

Chen, C., Yu, Z., Li, Y., Fichna, J., & Storr, M. (2014) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x14500669 · Cited by 140 · see citing works

Role of Berberine in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

Chu, M., Zhang, M., Liu, Y., Kang, J., Chu, Z.-Y., Yin, K., Ding, L., Ding, R., Xiao, R.-X., Yin, Y.-N., et al. (2016) · Scientific Reports · doi:10.1038/srep24748 · Cited by 124 · see citing works

Berberine suppresses influenza virus‐triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS

Liu, H., You, L.-M., Wu, J., Zhao, M., Guo, R., Zhang, H., Su, R., Mao, Q., Deng, D., & Hao, Y. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma0320-358rr · Cited by 100 · see citing works

Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art

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Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)

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Protective effect of berberine on doxorubicin-induced acute hepatorenal toxicity in rats

Chen, X., Zhang, Y., Zhu, Z., Liu, H., Guo, H., Chen, X., Xie, K., ZHANG, X., & Su, S. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5017 · Cited by 114 · see citing works

Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds

Li, M., Shu, X., Xu, H., Zhang, C., Yang, L., Zhang, L. R., & Ji, G. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0987-5 · Cited by 114 · see citing works

Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion

Pérez-Rubio, K. G., González-Ortiz, M., Martínez-Abundis, E., Robles-Cervantes, J. A., & Espinel-Bermúdez, M. C. (2013) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2012.0183 · Cited by 113 · see citing works

Effects of berberine on lipid profile in subjects with low cardiovascular risk

Derosa, G., D'Angelo, A., Bonaventura, A., Bianchi, L., Romano, D., & Maffioli, P. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.776037 · Cited by 112 · see citing works

Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels?

Cicero, A. F. G., Fogacci, F., Stoian, A. P., Vrablik, M., Al Rasadi, K., Banach, M., Toth, P. P., & Rizzo, M. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-021-00955-y · Cited by 110 · see citing works

Protective effect of berberine against LPS-induced injury in the intestine: a review

Izadparast, F., Riahi‐Zanjani, B., Yarmohammadi, F., Hayes, A. W., & Karimi, G. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2100682 · Cited by 109 · see citing works

Enhancing the Antitumor Activity of Berberine Hydrochloride by Solid Lipid Nanoparticle Encapsulation

Wang, L., Li, H.-T., Wang, S., Liu, R., Wu, Z., Wang, C., Wang, Y., & Chen, M. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0112-0 · Cited by 104 · see citing works

Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders

Caliceti, C., Franco, P., Spinozzi, S., Roda, A., & Cicero, A. F. G. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160411143314 · Cited by 91 · see citing works

Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends

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The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome

Kuang, H., Duan, Y., Li, D., Xu, Y., Ai, W., Li, W., Wang, Y., Liu, S., Li, M., Liu, X., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235404 · Cited by 83 · see citing works

Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters

Li, X., Zhao, Z., Huang, M., Feng, R., He, C., Ma, C., Luo, S.-H., Fu, J., Wen, B., Ren, L., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0629-3 · Cited by 81 · see citing works

Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer’s Disease

Hošťálková, A., Maříková, J., Opletal, L., Korábečný, J., Hulcová, D., Kuneš, J., Nováková, L., Pérez, D. I., Jun, D., Kucera, T., et al. (2019) · Journal of Natural Products · doi:10.1021/acs.jnatprod.8b00592 · Cited by 81 · see citing works

Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential

Fan, D., Liu, L., Wu, Z., & Cao, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180419141613 · Cited by 80 · see citing works

Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer’s disease

Singh, A. K., Singh, S. K., Nandi, M. K., Mishra, G., Maurya, A., Rai, A., Rai, G. K., Awasthi, R., Sharma, B., & Kulkarni, G. T. (2019) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524919666190820160053 · Cited by 79 · see citing works

Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes

Pierro, F. D., Putignano, P., Montesi, L., Moscatiello, S., Marchesini, G., & Villanova, N. (2013) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s54308 · Cited by 78 · see citing works

Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells

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Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects

Cicero, A. F. G., Derosa, G., Parini, A., Maffioli, P., D’Addato, S., Reggi, A., Giovannini, M., & Borghi, C. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.05.015 · Cited by 73 · see citing works

State of the art papers Dietary and nutraceutical approach to type 2 diabetes

Derosa, G., Limas, C. P., Macías, P. C., Estrella, A., & Maffioli, P. (2014) · Archives of Medical Science · doi:10.5114/aoms.2014.42587 · Cited by 74 · see citing works

Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): A position paper from the International Lipid Expert Panel (ILEP)

Rizzo, M., Colletti, A., Penson, P. E., Katsiki, N., Mikhailidis, D. P., Toth, P. P., Gouni‐Berthold, I., Mancini, J., MARAIS, D. P., Moriarty, P. M., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106679 · Cited by 69 · see citing works

Berberine suppresses gero-conversion from cell cycle arrest to senescence

Zhao, H., Halicka, H. D., Li, J., & Darżynkiewicz, Z. (2013) · Aging · doi:10.18632/aging.100593 · Cited by 70 · see citing works

Update on the Benefits and Mechanisms of Action of the Bioactive Vegetal Alkaloid Berberine on Lipid Metabolism and Homeostasis

Wang, Y., & Zidichouski, J. A. (2018) · Cholesterol · doi:10.1155/2018/7173920 · Cited by 68 · see citing works

Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

Zhang, Y., Yang, S., Li, M., Iqbal, J., Bourantas, C. V., Mi, Q., Yu, Y., Li, J., Zhao, S., Tian, N., et al. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12309 · Cited by 67 · see citing works

Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine

Duan, Y., Liu, T., Zhou, Y. G., Dou, T., & Yang, Q. K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004351 · Cited by 66 · see citing works

Hypertension and Dyslipidemia Combined Therapeutic Approaches

Borghi, C., Fogacci, F., Agnoletti, D., & Cicero, A. F. G. (2022) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-022-00507-8 · Cited by 65 · see citing works

Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury

Kysenius, K., Brunello, C. A., & Huttunen, H. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107129 · Cited by 65 · see citing works

Berberis aristata / Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients

Derosa, G., Bonaventura, A., Bianchi, L., Romano, D., D’Angelo, A., Fogari, E., & Maffioli, P. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.832751 · Cited by 64 · see citing works

Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo

Liu, C., Wang, Z., Song, Y., Wu, D., Zheng, X., Li, P., Jin, J., Xu, N., & Li, L. (2015) · BioMed Research International · doi:10.1155/2015/313808 · Cited by 63 · see citing works

Proteomic investigation into the action mechanism of berberine against Streptococcus pyogenes

Du, G., Le, Y.-J., Sun, X., Yang, X.-Y., & He, Q. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103666 · Cited by 61 · see citing works

Neuroprotective effect of berberine is mediated by MAPK signaling pathway in experimental diabetic neuropathy in rats

Zhou, J., Du, X., Long, M., Zhang, Z., Zhou, S., Zhou, J., & Qian, G. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.02.007 · Cited by 61 · see citing works

Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial

Zhao, J. V., Yeung, W.-F., Chan, Y.-H., Vackova, D., Leung, J. Y. Y., Ip, D. K. M., Zhao, J., Ho, W.-K., Tse, H.-F., & Schooling, C. M. (2021) · Nutrients · doi:10.3390/nu13082550 · Cited by 58 · see citing works

Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner

Chen, C., Lü, M., Pan, Q., Fichna, J., Zheng, L., Wang, K., Yu, Z., Li, Y., Li, K., Song, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145556 · Cited by 58 · see citing works

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast

Jiao, X., Fu, X., Li, Q., Bu, J., Liu, X., Savolainen, O. I., Huang, L., Guo, J., Nielsen, J., & Chen, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-53045-3 · Cited by 56 · see citing works

Green-Synthesized Silver and Selenium Nanoparticles Using Berberine: A Comparative Assessment of In Vitro Anticancer Potential on Human Hepatocellular Carcinoma Cell Line (HepG2)

Khaled, A. M., Othman, M. S., Obeidat, S. T., Aleid, G. M., Aboelnaga, S. M. H., Fehaid, A., Hathout, H. M. R., Bakkar, A., Moneim, A. E. A., El‐Garawani, I. M., et al. (2024) · Cells · doi:10.3390/cells13030287 · Cited by 54 · see citing works

The effect of berberine supplementation on obesity indices: A dose– response meta-analysis and systematic review of randomized controlled trials

Xiong, P., Niu, L., Talaei, S., Kord‐Varkaneh, H., Clark, C. C. T., Găman, M., Rahmani, J., Dorosti, M., Mousavi, S. M., Zarezadeh, M., et al. (2020) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2020.101113 · Cited by 56 · see citing works

Berberine protects endothelial progenitor cell from damage of TNF-α via the PI3K/AKT/eNOS signaling pathway

Xiao, M., Men, L. N., Xu, M. G., Wang, G. B., Lv, H. T., & Liu, C. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.09.024 · Cited by 52 · see citing works

Statin therapy and related risk of new-onset type 2 diabetes mellitus

Ruscica, M., Macchi, C., Morlotti, B., Sirtori, C. R., & Magni, P. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2014.03.003 · Cited by 51 · see citing works

Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects

Cicero, A. F. G., Morbini, M., Rosticci, M., D’Addato, S., Grandi, E., & Borghi, C. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000445359 · Cited by 45 · see citing works

O-Hexadecyl-Dextran Entrapped Berberine Nanoparticles Abrogate High Glucose Stress Induced Apoptosis in Primary Rat Hepatocytes

Kapoor, R., Singh, S., Tripathi, M., Bhatnagar, P., Kakkar, P., & Gupta, K. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089124 · Cited by 44 · see citing works

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Habtemariam, S. (2020) · Biomedicines · doi:10.3390/biomedicines8040090 · Cited by 42 · see citing works

Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring

Khater, S. I., Almanaa, T. N., Fattah, D. M. A., Khamis, T., Seif, M. M., Dahran, N. A., Alqahtani, L. S., Metwally, M. M. M., Mostafa, M., Albedair, R. A., et al. (2023) · Antioxidants · doi:10.3390/antiox12061220 · Cited by 40 · see citing works

The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus

Derosa, G., D’Angelo, A., & Maffioli, P. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.08.004 · Cited by 40 · see citing works

Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine

Heidarian, E., Rafieian‐Kopaei, M., Khoshdel, A., & Bakhshesh, M. (2014) · Asian Pacific Journal of Tropical Biomedicine · doi:10.12980/apjtb.4.2014c474 · Cited by 40 · see citing works

Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses

Derosa, G., Romano, D., D’Angelo, A., & Maffioli, P. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.043 · Cited by 40 · see citing works

Poor permeability and absorption affect the activity of four alkaloids from Coptis

Cui, H., Zhang, Q., Wang, J., Chen, J., Zhang, Y., & Tong, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4288 · Cited by 40 · see citing works

Structure–Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer

Xu, B., Jiang, X., Xiong, J., Lan, J., Tian, Y., Zhong, L., Wang, X., Xu, N., Cao, H., Zhang, W., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00088 · Cited by 40 · see citing works

Novel nutraceutic therapies for the treatment of metabolic syndrome

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Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation.

Hu, X., Zhang, Y., Xue, Y., Zhang, Z., & Wang, J. (2018) · Europe PMC (PubMed Central) · Cited by 38 · see citing works

In search of antiaging modalities: Evaluation of mTOR‐ and ROS/DNA damage‐signaling by cytometry

Darżynkiewicz, Z., Zhao, H., Halicka, H. D., Li, J., Lee, Y., Hsieh, T., & WU, J. M. (2014) · Cytometry Part A · doi:10.1002/cyto.a.22452 · Cited by 38 · see citing works

Atheroprotective effects and molecular targets of bioactive compounds from traditional Chinese medicine

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Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action

Firouzi, S., Malekahmadi, M., Ghayour‐Mobarhan, M., Ferns, G. A., & Rahimi, H. R. (2018) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s181572 · Cited by 37 · see citing works

Berberine containing quadruple therapy for initial Helicobacter pylori eradication

Zhang, D., Li, K., Ni, Z., Chen, Y., Zhang, L., Zhu, S., Li, C., Shang, L., Liang, J., & Shi, Y. (2017) · Medicine · doi:10.1097/md.0000000000007697 · Cited by 36 · see citing works

Effect of berberine associated with photodynamic therapy in cell lines

de Oliveira, P. M., Lopes, T. Z., Tedesco, A. C., Rahal, P., & Calmon, M. F. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.102045 · Cited by 35 · see citing works

Effect of red yeast rice combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects

Cicero, A. F. G., Morbini, M., Parini, A., Urso, R., Rosticci, M., Grandi, E., & Borghi, C. (2016) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s91817 · Cited by 33 · see citing works

Berberine as a Potential Multi-Target Agent for Metabolic Diseases: A Review of Investigations for Berberine

Wang, S., Zhang, X., Cai, B., & Chen, Q. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200910105612 · Cited by 33 · see citing works

Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials

Millán, J., Cicero, A. F. G., Torres, F., & Anguera, A. (2016) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2016.03.002 · Cited by 31 · see citing works

Popular functional foods and nutraceuticals with lipid lowering activity and in relation to cardiovascular disease, dyslipidemia, and related complications: an overview

Chiu, H., Shen, Y., Venkatakrishnan, K., & Wang, C. (2018) · Journal of Food Bioactives · doi:10.31665/jfb.2018.2137 · Cited by 30 · see citing works

Berberis aristata/Silybum marianum fixed combination (Berberol®) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: A randomized, placebo-controlled, clinical trial

Derosa, G., Romano, D., D’Angelo, A., & Maffioli, P. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.11.018 · Cited by 30 · see citing works

Role of Nutraceuticals in Hypolipidemic Therapy

Barbagallo, C. M., Cefalu, A. B., Noto, D., & Averna, M. R. (2015) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2015.00022 · Cited by 29 · see citing works

Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Chen, X., Guo, H., Li, Q., Zhang, Y., Liu, H., Zhang, X., Xie, K., Zhu, Z., Miao, Q., & Su, S. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9476 · Cited by 29 · see citing works

In vitro studies of berberine metabolism and its effect of enzyme induction on HepG2 cells

Cui, H., Zhang, Q., Wang, J., Chen, J., Zhang, Y., & Tong, X. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.10.018 · Cited by 29 · see citing works

Food and plant bioactives for reducing cardiometabolic disease: How does the evidence stack up?

Cicero, A. F. G., & Colletti, A. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.04.001 · Cited by 29 · see citing works

The effects of berberine supplementation on cardiovascular risk factors in adults: a systematic review and dose-response meta-analysis

Zamani, M., Zarei, M., Nikbaf-Shandiz, M., Hosseini, S., Shiraseb, F., & Asbaghi, O. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1013055 · Cited by 28 · see citing works

Berberine Attenuates Vascular Remodeling and Inflammation in a Rat Model of Metabolic Syndrome

Li, X., Li, C., Xiao, J., Gao, H., Wang, H., Zhang, X., Zhang, C., & Ji, X. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00828 · Cited by 28 · see citing works

The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review

Parthasarathy, M., & Prince, S. E. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06444-4 · Cited by 28 · see citing works

Fructus Mume Formula in the Treatment of Type 2 Diabetes Mellitus: A Randomized Controlled Pilot Trial

Tu, X., Xie, C., Wang, F., Chen, Q., Zhihuang, Z., Zhang, Q., Wang, X., Zhong, S., & Jordan, J. B. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/787459 · Cited by 28 · see citing works

Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial

Cicero, A. F. G., Rosticci, M., Parini, A., Morbini, M., Urso, R., Grandi, E., & Borghi, C. (2015) · Nutrition Journal · doi:10.1186/s12937-015-0019-y · Cited by 27 · see citing works

Randomised clinical trial of Berberis vulgaris root extract on glycemic and lipid parameters in type 2 diabetes mellitus patients

Tahmasebi, L., Zakerkish, M., Golfakhrabadi, F., & Namjoyan, F. (2019) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2019.100998 · Cited by 26 · see citing works

Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials

Amini, M. R., Sheikhhossein, F., Naghshi, S., Djafari, F., Askari, M., Shahinfar, H., Safabakhsh, M., Jafari, A., & Shab‐Bidar, S. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102337 · Cited by 26 · see citing works

An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia

Derosa, G., D’Angelo, A., Vanelli, A., & Maffioli, P. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s232791 · Cited by 26 · see citing works

Effect of berberine on PPAR α -NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV

Qiu, H., Wu, Y., Wang, Q., Liu, C., Xue, L., Wang, H., Wu, Q., & Jiang, Q. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1257642 · Cited by 25 · see citing works

Additional therapy for cholesterol lowering in ezetimibe-treated, statin-intolerant patients in clinical practice: results from an internal audit of a university lipid clinic

Cicero, A. F. G., Morbini, M., Bove, M., D’Addato, S., Fogacci, F., Rosticci, M., & Borghi, C. (2016) · Current Medical Research and Opinion · doi:10.1080/03007995.2016.1190326 · Cited by 23 · see citing works

Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly

Yi, C.-M., Yu, J., Kim, H., Lee, N., Kim, S. W., Lee, N.-J., Lee, J. H., Seong, J., Kim, N., & Inn, K. (2017) · Chemical Communications · doi:10.1039/c7cc02789c · Cited by 23 · see citing works

Wu-Mei-wan protects pancreatic β cells by inhibiting NLRP3 Inflammasome activation in diabetic mice

Yang, X., Lu, F., Li, L., Li, J., Luo, J., Zhang, S., Liu, X., & Chen, G. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2443-6 · Cited by 23 · see citing works

The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature

Derosa, G., D’Angelo, A., & Maffioli, P. (2022) · Phytotherapy Research · doi:10.1002/ptr.7564 · Cited by 24 · see citing works

Berberine ameliorates nonalcoholic fatty liver disease-induced bone loss by inhibiting ferroptosis

Gu, S., Wang, J., Yu, S., Zhang, S., Gao, T., Yan, D., Xie, R., Gu, M., Yu, M., Zhang, Z., et al. (2024) · Bone · doi:10.1016/j.bone.2024.117114 · Cited by 21 · see citing works

Berberine induced modulation of PHLPP2-Akt-MST1 kinase signaling is coupled with mitochondrial impairment and hepatoma cell death

Saxena, S., Shukla, S., & Kakkar, P. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.03.033 · Cited by 21 · see citing works

Lipid-lowering nutraceuticals update on scientific evidence

Derosa, G., Colletti, A., Maffioli, P., D’Angelo, A., Lupi, A., Zito, G., Mureddu, G. F., Raddino, R., Fedele, F., & Cicero, A. F. G. (2020) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000970 · Cited by 20 · see citing works

Multi-Omics Analysis Reveals the Resistance Mechanism and the Pathogens Causing Root Rot of Coptis chinensis

Song, X., Mei, P., Dou, T., Liu, Q., & Li, L. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04803-22 · Cited by 20 · see citing works

An update on the safety of nutraceuticals and effects on lipid parameters

Cicero, A. F. G., & Colletti, A. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1429404 · Cited by 20 · see citing works

Berberine: metabolic and cardiovascular effects in preclinical and clinical trials

Cicero, A. F. G. (2009) · Nutrition and Dietary Supplements · doi:10.2147/nds.s6084 · Cited by 31 · see citing works

Metabolic and cardiovascular effects of berberine: from preclinical evidences to clinical trial results

Cicero, A. F. G., & Ertek, S. (2009) · Clinical Lipidology · doi:10.2217/clp.09.41 · Cited by 48 · see citing works

Cardiovascular Effects of Berberine: A Review of the Literature

Bagade, A., Tumbigeremutt, V., & Pallavi, G. (2017) · Journal of Restorative Medicine · doi:10.14200/jrm.2017.6.0100 · Cited by 21 · see citing works

Berberine as a Natural Metabolic Modulator: A Comprehensive Review of Its Role in Diabetes, Obesity, and cardiovascular diseases

Manhl, R. G., Mozahim, M., & Yassser, A. N. (2026) · Academic International Journal of Medical Update · doi:10.59675/u412

BERBERINE AS AN ADJUVANT IN THE MANAGEMENT OF METABOLIC DISORDERS AND CARDIOVASCULAR RISK IN ADULTS

Archanjo, S. M., Magalhães, C. F., Rosa, L. S. T., Hanna, E., & Fernandes, C. (2025) · CIPEEX