The DOI matches its Crossref record; 76 of the 79 references it cites were found in a registry or an index.
Designing Randomized, Controlled Trials Aimed at Preventing or Delaying Functional Decline and Disability in Frail, Older Persons: A Consensus Report
Abstract
The discovery of effective interventions to prevent or delay disability in older persons is a public health priority. Most likely to benefit from such interventions are frail individuals who are not yet disabled and those with early disability who are at high risk of progression. In spite of this frail older persons have often been excluded from research on the assumption that they would not tolerate testing or benefit from treatment. The Interventions on Frailty Working Group developed recommendations to screen, recruit, evaluate, and retain frail older persons in clinical trials. Specific recommendations are: Eligibility screening should include a multistage process, to quickly exclude those who are too well and those who are too sick. Inclusion criteria should target those most likely to benefit, be meaningful to clinicians, and reflect advancements in the frailty research area. Disability outcome measures should include self‐reported, objective, and proxy measures. Strategies to improve retention and compliance and to monitor their effectiveness should be an integral part of the study design. Estimation of cost and sample size should contemplate high dropout rates and interference bycompeting outcomes. Additional research is needed to refine criteria for screening frail older persons, identify objective measures of disability that are reliable and valid in frail older persons, and improve the informed consent process for high‐risk participants, recognizing that research in this subgroup is essential to improving their health outcomes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Even so, an index with 30–40 variables has been shown to be sufficiently accurate for predicting adverse outcomes [6,14].”
From A standard procedure for creating a frailty index (2008) · cites this paper as [14]
Citations
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Self-citationGuralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792
Self-citationMoher, D., Schulz, K. F., & Altman, D. G. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04337-3 · Cited by 5,373
Validating the SF-36 health survey questionnaire: new outcome measure for primary care.
Brazier, J. E., Harper, R., Jones, N. M., O’Cathain, A., Thomas, K. J., Usherwood, T. P., & Westlake, L. (1992) · BMJ · doi:10.1136/bmj.305.6846.160 · Cited by 4,660
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130
Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E., & Wallace, R. B. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320902 · Cited by 4,083
Self-citationThe Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
Altman, D. G., Schulz, K. F., Moher, D., Egger, M., Davidoff, F., Elbourne, D., Gøtzsche, P. C., Lang, T., & for the CONSORT Group (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-8-200104170-00012 · Cited by 3,835
Guralnik, J. M., Ferrucci, L., Pieper, C. F., Leveille, S. G., Markides, K. S., Ostir, G. V., Studenski, S., Berkman, L. F., & Wallace, R. B. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.4.m221 · Cited by 2,898
Self-citationMoher, D., Schulz, K. F., & Altman, D. G. (2001) · BMC Medical Research Methodology · doi:10.1186/1471-2288-1-2 · Cited by 2,755
Tinetti, M. E., Baker, D. I., McAvay, G., Claus, E. B., Garrett, P., Gottschalk, M., Koch, M. L., Trainor, K. M., & Horwitz, R. I. (1994) · New England Journal of Medicine · doi:10.1056/nejm199409293311301 · Cited by 2,160
Research works printed but not linked: 2
- 10.1001/jama.1989.03420180087036 · DOI
- Vellas B, 2000, [Falls, frailty and osteoporosis in the elderly, A public health problem], 21, 608
Cited by
Sorted by citations
Items 401–500 of 999
Cumulative Deficits Frailty Index Predicts Outcomes for Solid Organ Transplant Candidates
Varughese, R. A., Theou, O., Li, Y., Huang, X., Chowdhury, N., Famure, O., Selzner, N., MacIver, J., Mathur, S., Kim, S. J., et al. (2021) · Transplantation Direct · doi:10.1097/txd.0000000000001094 · Cited by 36
Nixon, A. C., Bampouras, T. M., Gooch, H. J., Young, H. M. L., Finlayson, K. W., Pendleton, N., Mitra, S., Brady, M. E., & Dhaygude, A. P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251652 · Cited by 35
“However, additional high quality trials are needed [19] that include people living with frailty, individuals that are often poorly represented in interventional studies [20].”
BackgroundKenis, C., Decoster, L., Flamaing, J., Debruyne, P. R., Groof, I. D., Focan, C., Cornélis, F., Verschaeve, V., Bachmann, C., Bron, D., et al. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03574-7 · Cited by 34
“In the literature, frailty is often described as an abnormal physiological condition that makes a person more sensitive to stressors and increases the risk of negative health outcomes [15, 16].”
BackgroundBautmans, I., Demarteau, J., Cruts, B., Geriatrics, J., & Mets, T. (2008) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-0243 · Cited by 34
Comans, T. A., Brauer, S., & Haines, T. P. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq054 · Cited by 32
“Previously published guidelines on conducting research with frail older persons have noted that other trials have similar problems with high dropout rates hampering clinical trials (39).”
BackgroundPrevención de la dependencia en las personas mayores
Gómez‐Pavón, J., Lesende, I. M., Cortés, J. J. B., Pajares, P. R., Pérez, F. F., Benedito, A. S., Abizanda, P., & Cuesta, J. D. P. (2007) · Revista Española de Geriatría y Gerontología · doi:10.1016/s0211-139x(07)75736-0 · Cited by 37
Sobrecarga de trabalho em cuidadores de idosos fragilizados que vivem no domicílio
Stackfleth, R., Diniz, M. A., Fhon, J. R. S., Vendruscolo, T. R. P., Fabrício-Whebe, S. C. C., Marques, S., & Rodrigues, R. A. P. (2012) · Acta Paulista de Enfermagem · doi:10.1590/s0103-21002012000500019 · Cited by 33
“Fragility has multidimensional, heterogeneous and unstable aspects that differ from incapacity (disability) or the natural aging process (10).”
BackgroundAnalysis of the physical and functional parameters of older adults with chronic venous disease
de Moura, R. M. F., Gomes, H. D. A., da Silva, S. L. A., Britto, R. R., & Dias, R. C. (2012) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.05.005 · Cited by 33
“66 m with comfortable speed, being disregarded the initial and final two meters according to recommendations by Kressig and Beauchet (2006). Those participants, who were using elastic stockings or compressive bandages in the LL, removed them before the completion of the tests.”
MethodLauzé, M., Martel, D., Agnoux, A., Sirois, M., Émond, M., Daoust, R., & Aubertin-Leheudre, M. (2018) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-017-0938-8 · Cited by 34
Factors associated with poor balance ability in older adults of nine high-altitude communities
Urrunaga‐Pastor, D., Moncada–Mapelli, E., Runzer-Colmenares, F. M., Bailón-Valdez, Z., Samper‐Ternent, R., Rodríguez‐Mañas, L., & Parodi, J. F. (2018) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2018.04.013 · Cited by 33
Stam, H., van der Wouden, J. C., Hugtenburg, J. G., Twisk, J. W. R., van der Horst, H. E., & Maarsingh, O. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204876 · Cited by 33
Ohta, Y., Nomura, E., Hatanaka, N., Osakada, Y., Matsumoto, N., Sasaki, R., Tsunoda, K., Takemoto, M., Tadokoro, K., Hishikawa, N., et al. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.08.062 · Cited by 34
Young, H. M. L., March, D. S., HIGHTON, P. J., Graham-Brown, M. P. M., Churchward, D. R., Grantham, C. E., Goodliffe, S., Jones, W., Cheung, M.-M., Greenwood, S. A., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-041227 · Cited by 35
Atividades Avançadas de Vida Diária (AAVD) e desempenho cognitivo entre idosos
de Oliveira, E. M., da Silva, H. S., Lopes, A., Cachioni, M., Falcão, D. V. D. S., Batistoni, S. S. T., Neri, A. L., & Yassuda, M. S. (2015) · Psico-USF · doi:10.1590/1413-82712015200110 · Cited by 33
Cook, W. L. (2009) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2009.07.008 · Cited by 33
Adding Challenge to Performance-Based Tests of Walking
Bandinelli, S., Pozzi, M., Lauretani, F., Phillips, C. L., Shumway‐Cook, A., Guralnik, J. M., & Ferrucci, L. (2006) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/01.phm.0000233210.69400.d4 · Cited by 33
Self-citationFreedman, V. A., Hodgson, N. A., Lynn, J., Spillman, B. C., Waidmann, T., Wilkinson, A., & Wolf, D. A. (2006) · Milbank Quarterly · doi:10.1111/j.1468-0009.2006.00456.x · Cited by 33
“Clinical trials should remedy this omission and seek ways to include this group (Ferrucci et al. 2004).”
BackgroundCastaneda‐Sceppa, C., Price, L. L., Noel, S. E., Midle, J. B., Falcón, L. M., & Tucker, K. L. (2010) · Journal of Aging and Health · doi:10.1177/0898264310366738 · Cited by 32
“Poor physical function refers to impairment or inability to perform any of these physiological domains (Ferrucci et al., 2004).”
BackgroundMichael, Y., Gold, R., Perrin, N., & Hillier, T. (2011) · Journal of Aging and Health · doi:10.1177/0898264311412597 · Cited by 28
“, 2006), and are strong predictors of outcomes such as disability, frailty, and mortality (Ferrucci et al., 2004).”
BackgroundLife satisfaction and frailty among older adults
Wilhelmson, K., Fritzell, E., Eklund, K., & Dahlin‐Ivanoff, S. (2013) · Health Psychology Research · doi:10.4081/hpr.2013.e32 · Cited by 32
“*Dissatisfied (1-3) or rather satisfied (4) at the scale of percieved satisfaction with life as a whole (1-6), LiSat.”
BackgroundUchmanowicz, I., Lisiak, M., Wleklik, M., Gurowiec, P. J., & Kałużna‐Oleksy, M. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s204121 · Cited by 32
“This leads to adverse consequences.(16) FS is an important risk factor in the development of complications in older adults and those with chronic illnesses.”
Backgroundvon Bonsdorff, M. B., Leinonen, R., Kujala, U. M., Heikkinen, E. M., Törmäkangas, T., Hirvensalo, M. H., Rasinaho, M., Karhula, S., Mänty, M., & Rantanen, T. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02000.x · Cited by 32
“In terms of maximal effectiveness, persons at high risk of developing subsequent disability should be targeted, because they are potentially the greatest beneficiaries of such interventions.(1,6,7) Randomized controlled trials have shown that physical activity counseling for older persons increases physical activity i…”
BackgroundThe Health and Retirement Study
Stoiko, R. R. (2014) · The International Journal of Aging and Human Development · doi:10.1177/0091415015574186 · Cited by 39
Swedish Health Care Professionals’ View of Frailty in Older Persons
Gustafsson, S., Edberg, A., & Dahlin‐Ivanoff, S. (2011) · Journal of Applied Gerontology · doi:10.1177/0733464810396874 · Cited by 31
Pouw, M. A., Calf, A. H., Munster, B. C. V., ter Maaten, J. C., Smidt, N., & de Rooij, S. E. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020332 · Cited by 34
“Cognitive impairment (ie, dementia) is an important contributor to frailty in older people.(12) Cognitively impaired older people are more likely to become hospitalised and once admitted, they experience longer stays than their peers without cognitive impairment.”
BackgroundBautmans, I., Vantieghem, S., Gorus, E., Grazzini, Y.-R., Fierens, Y., Pool‐Goudzwaard, A., & Mets, T. F. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.03.002 · Cited by 31
“According to the present guidelines (Ferrucci et al., 2004), stable morbidity was not an exclusion criterion per se for elderly participants.”
Fougère, B., Vellas, B. J., van Kan, G. A., & Cesari, M. (2015) · Translational Neuroscience · doi:10.1515/tnsci-2015-0009 · Cited by 30
RetractedGrönstedt, H. K., Hellström, K., Bergland, A., Helbostad, J. L., Puggaard, L., Andresen, M., Granbo, R., & Frändin, K. (2011) · Aging Clinical and Experimental Research · doi:10.1007/bf03337766 · Cited by 30
Metzelthin, S., van Rossum, E., de Witte, L., Hendriks, M. R., & Kempen, G. I. J. M. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-511 · Cited by 30
“population and restraints in healthcare expenditure and availability of informal care, disability in frail older people is a public health problem [3] and its prevention is considered to be a priority for research and clinical practice in geriatric care [7].”
BackgroundManini, T. M., Clark, B. C., Tracy, B. L., Burke, J. R., & Ploutz‐Snyder, L. L. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0048-x · Cited by 30
“More importantly, reports of training adaptations have excluded frail or functionally limited older persons because of concerns about comorbidity, heterogeneity of responses, and safety (Ferrucci et al. 2004).”
BackgroundDramé, M., Novella, J., Jolly, D., Lanièce, I., Somme, D., Heitz, D., Gauvain, J. B., Voisin, T., de Wazières, B., Gonthier, R., et al. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0164-8 · Cited by 30
“Physical frailty has been defined according to various criteria, such as non-intentional weight loss (45); lower fat-free-soft tissue mass and lower fat mass (46); a body mass index lower than 21 (47); change in four instrumental activities of daily living performance (48) and more recently, as a composite measure (5,…”
Gray, S. L., Boudreau, R. M., Newman, A. B., Studenski, S. A., Shorr, R. I., Bauer, D. C., Simonsick, E. M., Hanlon, J. T., & for the Health, A. A. B. C. S. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03721.x · Cited by 31
Self-citationAssociação entre sintomas de insônia, cochilo diurno e quedas em idosos da comunidade
Pereira, A. A., Ceolim, M. F., & Neri, A. L. (2013) · Cadernos de Saúde Pública · doi:10.1590/s0102-311x2013000300011 · Cited by 36
Luciani, A., Dottorini, L., Battisti, N. M. L., Bertuzzi, C., Caldiera, S., Floriani, I., Zonato, S., Ferrari, D., & Foa, P. (2012) · Annals of Oncology · doi:10.1093/annonc/mds471 · Cited by 30
“Although it is widely accepted that clinicians adopting oncological instruments as the PS can promptly recognize some disabilities, it is important to have an easy-to-use instrument to help professionals rapidly identify the patients at risk of developing inacceptable toxicity, which has become a public health priorit…”
BackgroundBoccardi, V., Baroni, M., Paolacci, L., Ercolani, S., Longo, A., Giordano, M., Ruggiero, C., & Mecocci, P. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0787-x · Cited by 31
Fall-related factors among less and more active older outpatients
Perracini, M. R., Teixeira, L. F., Ramos, J. D. L. A., Pires, R. S., & Najas, M. S. (2012) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552012005000009 · Cited by 29
Asmus-Szepesi, K. J., de Vreede, P. L., Flinterman, L. E., Nieboer, A. P., Bakker, T. J. E. M., Borsboom, G., Mackenbach, J. P., & Steyerberg, E. W. (2013) · Age and Ageing · doi:10.1093/ageing/aft126 · Cited by 29
“Identifying hospitalised people at risk for functional dependence is important, as it allows for reactivation treatment to be tailored to individual patients [6, 8, 9].”
BackgroundSelf-perceived care needs in older adults with joint pain and comorbidity
Hermsen, L. A. H., Hoogendijk, E. O., van der Wouden, J. C., Smalbrugge, M., Leone, S. S., van der Horst, H. E., & Dekker, J. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0795-7 · Cited by 29
Goudzwaard, J. A., de Ronde, M., van Hoorn, F. E. D., Kwekkeboom, E. H. C., Lenzen, M. J., van Wiechen, M. P. H., Ooms, J. F., Nuis, R.-J. M., Mieghem, N. M. V., Daemen, J., et al. (2020) · Age and Ageing · doi:10.1093/ageing/afaa071 · Cited by 29
“, because of diminished physiological reserve [34,35]; therefore treating AS alone might not be sufficient to improve overall HRQoL because there still remain factors impairing HRQOL [34,36].”
BackgroundOtto, A.-K., Pietschmann, J., Appelles, L.-M., Bebenek, M., Bischoff, L. L., Hildebrand, C., Johnen, B., Jöllenbeck, T., KEMMLER, W. K., Klotzbier, T. J., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-038202 · Cited by 31
Gorus, E., Raedt, R. D., Lambert, M., Lemper, J., & Mets, T. F. (2006) · International Psychogeriatrics · doi:10.1017/s1041610205002723 · Cited by 29
“, 2000), instead of excluding them from the study as seen in most previous research (Ferucci et al., 2004).”
BackgroundResultAtuação da fisioterapia na síndrome de fragilidade: revisão sistemática
Arantes, P. M. M., Alencar, M. A., Dias, R. C., Dias, J. M. D., & Pereira, L. S. M. (2009) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552009005000061 · Cited by 29
Effects of Square-Stepping Exercise on balance and depressive symptoms in older adults
Pereira, J. R., Gobbi, S., Teixeira, C. V. L., Nascimento, C. M. C., Corazza, D. I., Vital, T. M., Hernández, S. S. S., Stella, F., & Shigematsu, R. (2014) · Motriz Revista de Educação Física · doi:10.1590/s1980-65742014000400013 · Cited by 31
Clegg, A. P., Barber, S., Young, J. B., Förster, A., & Iliffe, S. (2011) · Trials · doi:10.1186/1745-6215-12-143 · Cited by 29
Aznar-Tortonda, V., Palazón‐Bru, A., la Rosa, D. M. F.-D., Espínola-Morel, V., Pérez-Pérez, B. F., León-Ruiz, A. B., & Gil-Guillén, V. F. (2019) · British Journal of General Practice · doi:10.3399/bjgp19x706577 · Cited by 28
“11,12 Fried et al identified a phenotype of frailty that was predictive of adverse outcomes, such as death; 13 however, using the tool involves having answers to personal questions that must be obtained through an interview.”
MethodBuchman, A. S., Leurgans, S. E., Wang, T., Beeri, M. S., Agarwal, P., Dawe, R. J., Delbono, O., & Bennett, D. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245680 · Cited by 28
Weiss, C. O., Cappola, A. R., Varadhan, R., & Fried, L. P. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04101.x · Cited by 28
Self-citationCurrent and Future Directions in Frailty Research
Mohandas, A., Reifsnyder, J., Jacobs, M. L., & Fox, T. (2011) · Population Health Management · doi:10.1089/pop.2010.0066 · Cited by 30
“The Frailty Working Group 39 stated that the recruitment process for these populations may be complex and expensive, and recommended a multistage selection process that would involve excluding populations who are robust and identifying a frail subset of the population based on specific domains of…”
InfluentialHammar, I. O., Dahlin‐Ivanoff, S., Wilhelmson, K., & Eklund, K. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-126 · Cited by 28
“Frailty can be seen as a continuum from robustness, to pre-frail, and to the final full frailty phase [25].”
BackgroundExercise and health in frail elderly people: a review of randomized controlled trials
Barreto, P. D. S. (2009) · European Review of Aging and Physical Activity · doi:10.1007/s11556-009-0050-0 · Cited by 28
“[44], frailty as a result of reduced cognition is considered a distinct clinical entity, although, decline in cognition may be found in frail persons.”
BackgroundDer‐Martirosian, C., Kritz‐Silverstein, D. C., & Barrett-Connor, E. L. (2010) · Quality of Life Research · doi:10.1007/s11136-010-9700-y · Cited by 28
Qing, L., Zhu, Y., Feng, L., Wang, X., Sun, Y., Yu, C., & Ni, J. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-085645 · Cited by 27
Provencher, V., Demers, L., Gagnon, L., & Gélinas, I. (2011) · International Psychogeriatrics · doi:10.1017/s104161021100216x · Cited by 27
“As underscored by Ferrucci et al. (2004), frail older adults are not an easy population to get involved in a research project.”
BackgroundPredicting functional decline in older patients undergoing cardiac surgery
Hoogerduijn, J. G., de Rooij, S. E., Grobbee, D. E., & Schuurmans, M. J. (2013) · Age and Ageing · doi:10.1093/ageing/aft165 · Cited by 27
“This risk assessment can then be followed by a comprehensive geriatric assessment (CGA) and targeted interventions to prevent functional decline [16, 17].”
BackgroundAssociation of frailty in hospitalized and institutionalized elderly in the community-dwelling
Fabrício-Wehbe, S. C. C., Rodrigues, R. A. P., Haas, V. J., Fhon, J. R. S., & Diniz, M. A. (2016) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167.2016690411i · Cited by 27
Fristedt, S., Nystedt, P., & Skogar, Ö. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s208388 · Cited by 27
“Similar challenges were described previously.(25) Nevertheless, research targeting interventions for the frail elderly is of vital importance to improving healthcare.”
BackgroundFrailty assessment in the geriatric outpatient clinic
Kim, H., Higgins, P. A., Canaday, D. H., Burant, C. J., & Hornick, T. R. (2013) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12057 · Cited by 27
Patterns and Predictors of Recovery from Exhaustion in Older Adults: The Cardiovascular Health Study
Whitson, H. E., Thielke, S. M., Diehr, P. H., O’Hare, A. M., Chaves, P. H. M., Zakai, N. A., Arnold, A. M., Chaudhry, S. I., Ives, D. G., & Newman, A. B. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03238.x · Cited by 27
Demougeot, L., Rolland, Y., Gérard, S., Pennetier, D., Duboué, M., Vellas, B. J., & Cesari, M. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-861 · Cited by 27
“It is possible that the frail older persons living in nursing homes may be specially amenable of beneficiating from preventive interventions and protocols [16].”
BackgroundSíndrome da fragilidade no idoso comunitário com osteoartrite
Miguel, R. D. C. C., Dias, R. C., Dias, J. M. D., da Silva, S. L. A., Filho, P. R. M., & Ribeiro, T. M. D. S. (2012) · Revista Brasileira de Reumatologia · doi:10.1590/s0482-50042012000300004 · Cited by 27
Hirvensalo, M. H., Heikkinen, E. M., Lintunen, T., & Rantanen, T. (2005) · Preventive Medicine · doi:10.1016/j.ypmed.2004.11.020 · Cited by 27
Blozik, E., Wagner, J. T., Gillmann, G., Iliffe, S., Renteln-Kruse, W. V., Lubben, J., Beck, J. C., Stuck, A. E., & Clough‐Gorr, K. M. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03325223 · Cited by 27
“Despite this, multidimensional geriatric health-risk assessment usually only includes single-item proxy measures, such as living alone status (13, 14).”
BackgroundGroningen frailty indicator in older patients with end-stage renal disease
Meulendijks, F. G., Hamaker, M. E., Boereboom, F. T. J., Kalf, A., Vogtländer, N. P. J., & Munster, B. C. V. (2015) · Renal Failure · doi:10.3109/0886022x.2015.1077315 · Cited by 29
“Frailty is considered to be a state of decreased physiological reserves, arising from cumulative deficits in multiple organ systems and resulting in a diminished resistance to stressors.(9,10) Frailty status can be assessed using a comprehensive geriatric assessment of the medical, psychosocial and functional abilitie…”
BackgroundSaenger, A. L. F., Caldas, C. P., Raı̂che, M., & da Motta, L. B. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.09.008 · Cited by 30
Bleijenberg, N., Boeije, H., Onderwater, A. T., & Schuurmans, M. J. (2015) · Journal of Gerontological Nursing · doi:10.3928/00989134-20150814-03 · Cited by 26
Yoo, J., Ha, Y., Kim, M., Seo, S., Kim, M., Lee, G.-Y., Seo, Y.-M., Sung, C., & Park, K. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02630-2 · Cited by 27
Berge, I., Barenfeld, E., Dahlin‐Ivanoff, S., Haak, M., & Lood, Q. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01817-z · Cited by 26
Frailty: a costly phenomenon in caring for elders with cognitive impairment
Butler, A. M., Gallagher, D., Gillespie, P., Crosby, L., Ryan, D., Lacey, L. A., Coen, R. F., O’Shea, E., & LAWLOR, B. A. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4306 · Cited by 26
“It lends itself in particular to the exploration of frailty in a chronically diseased population such as those with already established cognitive impairment (Ferrucci, 2004).”
BackgroundAssessing Smart Phones for Generating Life-Space Indicators
Wan, N., Qu, W., Whittington, J., Witbrodt, B. C., Henderson, M. P., Goulding, E. H., Schenk, A. K., Bonasera, S. J., & Lin, G. (2013) · Environment and Planning B Planning and Design · doi:10.1068/b38200 · Cited by 26
“Functional limitations or abilities to perform activities of daily living (ADLs) and/ or instrumental activities of daily living (IADLs) represent an important dimension of older adults’ health status (Ferrucci et al, 2004; Katz and Stroud, 1989).”
BackgroundInformation Technology for Active Ageing: A Review of Theory and Practice
Parra, C., Silveira, P., Far, I. K., Daniel, F., de Bruin, E. D., Cernuzzi, L., D’Andrea, V., & Casati, F. (2014) · Foundations and Trends® in Human–Computer Interaction · doi:10.1561/1100000053 · Cited by 27
“First, prevention of age-associated physical function decline and disabilities has gained importance and it has been pointed out that it should be the focus of societys attention [Guralnik et al. 1996; Ferrucci et al. 2004].”
BackgroundCorrelation between Frailty Level and Disability of the Elderly and Frailty Related Factors
Hyun, S., Jung, K.-Y., Hong, S. H., Shim, E. Y., Yoo, S.-H., Kim, M. Y., & Yoon, J. L. (2009) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2009.30.8.588 · Cited by 26
Rolland, Y., & Vellas, B. J. (2008) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2008.08.013 · Cited by 40
Hentschel, L., Rentsch, A., Lenz, F., Hornemann, B., Schmitt, J. M., Baumann, M. A., Ehninger, G., & Schuler, M. K. (2016) · Oncology Research and Treatment · doi:10.1159/000445365 · Cited by 25
Farid, K., Zhang, Y., Bachelier, D., Gilson, P., Teixeira, A., Safar, M. E., & Blacher, J. (2013) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2012.12.006 · Cited by 26
Incorporating Biomarkers of Frailty and Senescence in Cancer Therapeutic Trials
Hubbard, J. M., & Jatoi, A. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu046 · Cited by 25
Insulin-Like Growth Factor-1 Related to Disability Among Older Adults
Doi, T., Shimada, H., Makizako, H., Tsutsumimoto, K., Hotta, R., Nakakubo, S., & Suzuki, T. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv167 · Cited by 25
Rogan, S., Radlinger, L., Baur, H., Schmidtbleicher, D., de Bie, R. A., & de Bruin, E. D. (2016) · European Review of Aging and Physical Activity · doi:10.1186/s11556-016-0164-0 · Cited by 26
“Interventions performed with frail individuals often suffer from low adherence rates and are, therefore, advised to specifically include support and motivation strategies, as well as giving assistance to individuals to develop both goals and the strategies to achieve these [47, 48].”
BackgroundThe Association between Frailty and Disability among the Elderly in Rural Areas of Korea
Choi, Y.-S., Kim, M.-J., Lee, G.-Y., Seo, Y.-M., Seo, A.-R., Kim, B., Yoo, J., & Park, K. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16142481 · Cited by 25
“These syndromes lead to frequent falls and hospital visits, which ultimately lead to disability and death [2,3].”
BackgroundThe association between motor capacity and mobility performance: frailty as a moderator
Jansen, C.-P., Toosizadeh, N., Mohler, M. J., Najafi, B., Wendel, C. S., & Schwenk, M. (2019) · European Review of Aging and Physical Activity · doi:10.1186/s11556-019-0223-4 · Cited by 26
Contribution of the geriatrician to the management of cancer in older patients
Gosney, M. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.07.032 · Cited by 25
The effect of aging and inflammation on heat shock protein 27 in human monocytes and lymphocytes
Njemini, R., LAMBERT, M., Demanet, C., & Mets, T. F. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.006 · Cited by 24
Bez, J. P. D. O., & Neri, A. L. (2014) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232014198.09592013 · Cited by 25
Quantifying prosthetic gait deviation using simple outcome measures
Kark, L., Odell, R. A., McIntosh, A. S., & Simmons, A. (2016) · World Journal of Orthopedics · doi:10.5312/wjo.v7.i6.383 · Cited by 24
Fernández‐García, Á. I., Gómez‐Cabello, A., Moradell, A., Navarrete‐Villanueva, D., Pérez‐Gómez, J., Ara, I., Pedrero‐Chamizo, R., Subías-Perié, J., Muñiz-Pardos, B., Casajús, J. A., et al. (2020) · Sustainability · doi:10.3390/su12156246 · Cited by 31
“These undesirable consequences of frailty are often accompanied by an increased risk of suffering undesirable health outcomes, such as falls, dependence, hospitalization or death [2,4,18,19].”
BackgroundGiangregorio, L., Thabane, L., Adachi, J. D., Ashe, M. C., Bleakney, R. R., Braun, E. A., Cheung, A. M., Fraser, L.-A., Gibbs, J. C., Hill, K., et al. (2014) · Physical Therapy · doi:10.2522/ptj.20130625 · Cited by 24
Knobe, M., Giesen, M., Plate, S., Gradl-Dietsch, G., Buecking, B., Eschbach, D. A., van Laack, W., & Pape, H. (2016) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-016-0693-2 · Cited by 25
McCaskey, M. A., Schättin, A., Martin‐Niedecken, A. L., & de Bruin, E. D. (2018) · BioMed Research International · doi:10.1155/2018/4856146 · Cited by 27
“We will begin by discussing general solutions that address behaviour associated and physical function decline with age [8, 9].”
BackgroundMethodCreating the Next Generation of Translational Geroscientists
Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., et al. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16055 · Cited by 24
“They will involve multidomain and functional outcomes.(12) The field of geroscience can also be advanced through testing interventions in more traditional single-disease clinical trials with a disease-specific primary outcome if these trials incorporate elements like aging biomarkers and multidomain or functional seco…”
BackgroundTowards an integral conceptual model of frailty
Gobbens, R. J. J., Luijkx, K. G., Wijnen-Sponselee, M. T., & Schols, J. M. G. A. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0142-6 · Cited by 25
Increased intra-individual variability in stride length and reaction time in recurrent older fallers
Reelick, M. F., Kessels, R. P. C., Faes, M. C., Weerdesteyn, V., Esselink, R. A. J., & Rikkert, M. G. M. O. (2011) · Aging Clinical and Experimental Research · doi:10.1007/bf03337764 · Cited by 24
Disability and physical activity in late life—research models and approaches
Heikkinen, E. M. (2006) · European Review of Aging and Physical Activity · doi:10.1007/s11556-006-0004-8 · Cited by 24
“– There is also a need for studies aimed at preventing or delaying functional decline and disability in frail older persons [10], and attention should also be placed to coimpairments as predictors of functional decline and subsequent disability – Dose–response issues, concerning physical activity and health, present a…”
BackgroundCosta, T. B., & Neri, A. L. (2019) · Revista Brasileira de Epidemiologia · doi:10.1590/1980-549720190022 · Cited by 23
Association of frailty with fall events in older adults: A 12-year longitudinal study in Korea
Kim, Y., Yao, Y., Lee, S.-W., Veronese, N., Ma, S.-J., Park, Y., & Ju, S.-Y. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104747 · Cited by 23
Instruments to assess frailty in community dwelling older adults: A systematic review
Rasiah, J., Gruneir, A., Oelke, N. D., Estabrooks, C. A., Holroyd-Leduc, J. M., & Cummings, G. G. (2022) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2022.104316 · Cited by 24
Pao, Y.-C., Chen, C., Chang, C.-I., Chen, C., & Tsai, J. (2018) · Medicine · doi:10.1097/md.0000000000010933 · Cited by 23
Westgård, T., Wilhelmson, K., Dahlin‐Ivanoff, S., & Hammar, I. O. (2019) · Geriatrics · doi:10.3390/geriatrics4010016 · Cited by 23
“balance, motor processing, cognition, nutrition, endurance, and physical activity [3] are affected.”
BackgroundPolypharmacy in community-based older adults: results of the Fibra study
Marques, P. D. P., de Assumpção, D., Rezende, R., Neri, A. L., & Francisco, P. M. S. B. (2019) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1981-22562019022.190118 · Cited by 23
Andresen, M., Runge, U., Hoff, M., & Puggaard, L. (2009) · Journal of Aging and Health · doi:10.1177/0898264309348197 · Cited by 23
Outcomes of Surgery for Stress Urinary Incontinence in the Older Woman
Ellington, D. R., Erekson, E. A., & Richter, H. E. (2015) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2015.06.006 · Cited by 22
Loh, D. A., Hairi, N. N., Choo, W. Y., Hairi, F. M., Peramalah, D., Kandiben, S., Lee, P. L., Gani, N., Madzlan, M. F., Hamid, M. A. I. A., et al. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0002-7 · Cited by 22
“Multi-faceted approaches comprising an interdisciplinary healthcare team has proven more efficacious in encouraging behavioural change than a single approach in addressing functional difficulties [4], risk of falls [12], number of people who fall and fall rates [13,14] and poor nutrition status [15]; whether home-base…”
BackgroundInfluential
Metadata
- Authors
- Ferrucci, L., Guralnik, J. M., Studenski, S., Fried, L. P., Cutler, G. B., Walston, J. D., & The Interventions on Frailty Working Group
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2004-03-30
- Volume
- 52
- Issue
- 4
- Pages
- 625-634
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1562992882
- Cited by
- 1,027
- References
- 79
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 24 · 2023: 22 · 2022: 22 · 2021: 31 · 2020: 48 · 2019: 58 · 2018: 49 · 2017: 49 · 2016: 51 · 2015: 55 · 2014: 62 · 2013: 72 · 2012: 70
- FWCI
- 18.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Keywords
- frailty, older adults, disability prevention, functional decline, clinical trial design, participant recruitment, participant retention, sample size determination, dropout, informed consent
- MeSH terms
- Activities of Daily Living, Aged, Chronic Disease, Geriatrics, Persons with Disabilities, Health Priorities, Humans, Mass Screening, Periodicals as Topic, Planning Techniques, Primary Prevention, Public Health, Publishing, Research Design, Risk Factors, Geriatric Assessment, Randomized Controlled Trials as Topic, Frail Elderly, Outcome Assessment, Health Care, Sample Size, Disease Progression, Patient Selection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
