The DOI matches its Crossref record; 76 of the 79 references it cites were found in a registry or an index.
Designing Randomized, Controlled Trials Aimed at Preventing or Delaying Functional Decline and Disability in Frail, Older Persons: A Consensus Report
Abstract
The discovery of effective interventions to prevent or delay disability in older persons is a public health priority. Most likely to benefit from such interventions are frail individuals who are not yet disabled and those with early disability who are at high risk of progression. In spite of this frail older persons have often been excluded from research on the assumption that they would not tolerate testing or benefit from treatment. The Interventions on Frailty Working Group developed recommendations to screen, recruit, evaluate, and retain frail older persons in clinical trials. Specific recommendations are: Eligibility screening should include a multistage process, to quickly exclude those who are too well and those who are too sick. Inclusion criteria should target those most likely to benefit, be meaningful to clinicians, and reflect advancements in the frailty research area. Disability outcome measures should include self‐reported, objective, and proxy measures. Strategies to improve retention and compliance and to monitor their effectiveness should be an integral part of the study design. Estimation of cost and sample size should contemplate high dropout rates and interference bycompeting outcomes. Additional research is needed to refine criteria for screening frail older persons, identify objective measures of disability that are reliable and valid in frail older persons, and improve the informed consent process for high‐risk participants, recognizing that research in this subgroup is essential to improving their health outcomes.
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“Frail older persons are at high risk of accelerated physical and cognitive functional decline, disability and death.(6) The concept of frailty adopts an integrative approach that represents general properties of ageing and health rather than particular functional deficiency or decline.”
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Nieves, J. W., Zion, M., Pahor, M., Bernabei, R., Gussekloo, J., Simon, H., Park, J.-S., Li, T. M. W. Y., Lapuerta, P., & Williams, G. R. (2005) · Aging Clinical and Experimental Research · doi:10.1007/bf03324596 · Cited by 12
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Development of an application for mobile devices to identify the frailty phenotype among the elderly
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“related to study outcomes, ignoring missing data may bias findings (Ferrucci et al., 2004).”
BackgroundInfluentialThe clinically meaningful change in physical performance scores in an elderly cohort
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“These positive benefits suggest that for those older adults on the cusp of falling below their functional threshold in tasks of daily living, exercise could rehabilitate them toward increased independence (Ferrucci et al., 2004).”
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“Choosing the right instrument is paramount in the early detection of frailty [12, 13].”
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“Although therapeutic advances have prolonged survival, many patients suffer from a myriad of treatment-associated side effects, including the high frequency of individual symptoms and their overall severity [2,3].”
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“Each of the criteria (fatigue, resistance, ambulation, illness, and loss of weight) was obtained through a personal interview (Fried et al., 2001; Ferrucci et al., 2004; Rolfson et al., 2006).”
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Musculoskeletal Aging, Sarcopenia, and Cancer
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“Frail older adults have less muscle mass and strength than the non-frails [19] and have also lower levels of motor processing and slower gait speed [20].”
BackgroundResistance Training During Weight Loss in Overweight and Obese Older Adults: What Are the Benefits?
Delmonico, M. J., & Lofgren, I. E. (2010) · American Journal of Lifestyle Medicine · doi:10.1177/1559827610368245 · Cited by 9
“In particular, recent reports suggest that because obese older adults are at increased risk for disability, interventions that combine different strategies need to be investigated.(11) Past interventions that targeted obesity and/or sarcopenia in overweight and obese older adults rarely combined physical activity and…”
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Diagnostik und Behandlung physischer Frailty
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“Frailty overlaps with, but is not the same as, disability and comorbidity [3].”
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“1 Frailty is defined as a geriatric syndrome resulted from the declines of multiple physiological systems, has become one of the biggest challenges in facilitating healthy aging.([2,3,4]) It is often characterized bymarked vulnerability to adverse health outcomes, including falls, fractures, disability, hospitalizatio…”
BackgroundSelf-rated general and oral health and associated factors in independently-living older individuals
Tôrres, L. H. D. N., Fagundes, M. L. B., da Silva, D. D., Neri, A. L., Hilgert, J. B., Hugo, F. N., & de Sousa, M. D. L. R. (2020) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2020.vol34.0079 · Cited by 9
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Función y fragilidad: ¿qué tenemos que medir?
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“Frailty is a geriatric syndrome that is related to a deterioration of multiple physiological systems in high age [13], that often results in decreased abilities to perform daily activities and morbidity [14].”
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Does functional change predict the course of improvement in geriatric inpatient rehabilitation?
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A Simplified Frailty Index Predicts Mortality in Older Adults in Beijing
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“An index with 30–40 variables has been shown to be sufficiently accurate for predicting adverse outcomes.(11) We have previously developed and validated a 68-item FI based on the comprehensive geriatric assessment (CGA),(13) entitled the CGA-FI, in a large, older Chinese population.”
MethodPhysical function trends and their association with mortality in postmenopausal women
Laddu, D., Saquib, N., Manson, J. E., Arena, R. A., Shadyab, A. H., Weitlauf, J. C., Hovey, K. M., Andrews, C., Banack, H., Stefanick, M. L., et al. (2022) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001982 · Cited by 8
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“These measures are generally developed to capture the overall symptoms over a certain period of time in different everyday situations, and thus provide a reasonably accurate representation on the real-world performance (Ferrucci et al., 2004; Schmitter-Edgecombe, Parsey, & Cook, 2011).”
BackgroundScreening for frailty among seniors in clinical practice
Corapi, K. M., McGee, H. M., & Barker, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0288 · Cited by 8
O cuidado do idoso no contexto familiar: percepção da equipe de saúde da família
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Prevention of frailty through narrative intervention
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Valoración del paciente frágil en urgencias
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Frail elderly : identification and disability prevention in primary care
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Development of a wearable mobility monitoring system
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“2 Diaries and Questionnaires Diaries and questionnaires are used to assess mobility disability or disability in activities of daily living (ADL) by having the participants report on whether they have difficulties or need help in performing ADL or mobility related tasks [46].”
MethodFrailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort
Damanti, S., LORENZO, R. D., Citterio, L., Zagato, L., Brioni, E., Magnaghi, C., Simonini, M., Ruggiero, M. P., Santoro, S., Senini, E., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2024.1465066 · Cited by 7
Tóth, E. E., Vujić, A., Ihász, F., Barquín, R. R., & Szabó, A. (2024) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2024.101880 · Cited by 12
Alcohol Consumption among the Oldest Old and How It Changes during Two Years
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“Frailty, is a measure of potential risk of morbidity and functional disability [17] and has lately become an established concept in the research field of the elderly [17–20].”
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Self-citationIndividualizing medical treatment of overactive bladder
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“Frail elderly patients are more vulnerable to experiencing complications [46].”
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Identifying Patient Readmissions: Are Our Data Sources Misleading?
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“Frail individuals often have immobility, gait abnormalities, muscle weakness and poor balance (7).”
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Efficacy of Cardiac Rehabilitation in Heart Failure Patients With Low Body Mass Index
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Medical Outcome of Patients With Dementia in a Free-Standing Psychiatric Hospital
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AGING AND HEALTH TECHNOLOGY ASSESSMENT: AN IDEA WHOSE TIME HAS COME
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Measuring Outcomes of Multidimensional Interventions
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Metadata
- Authors
- Ferrucci, L., Guralnik, J. M., Studenski, S., Fried, L. P., Cutler, G. B., Walston, J. D., & The Interventions on Frailty Working Group
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2004-03-30
- Volume
- 52
- Issue
- 4
- Pages
- 625-634
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1562992882
- Cited by
- 1,027
- References
- 79
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 24 · 2023: 22 · 2022: 22 · 2021: 31 · 2020: 48 · 2019: 58 · 2018: 49 · 2017: 49 · 2016: 51 · 2015: 55 · 2014: 62 · 2013: 72 · 2012: 70
- FWCI
- 18.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Keywords
- frailty, older adults, disability prevention, functional decline, clinical trial design, participant recruitment, participant retention, sample size determination, dropout, informed consent
- MeSH terms
- Activities of Daily Living, Aged, Chronic Disease, Geriatrics, Persons with Disabilities, Health Priorities, Humans, Mass Screening, Periodicals as Topic, Planning Techniques, Primary Prevention, Public Health, Publishing, Research Design, Risk Factors, Geriatric Assessment, Randomized Controlled Trials as Topic, Frail Elderly, Outcome Assessment, Health Care, Sample Size, Disease Progression, Patient Selection
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