The DOI matches its Crossref record; 76 of the 79 references it cites were found in a registry or an index.
Designing Randomized, Controlled Trials Aimed at Preventing or Delaying Functional Decline and Disability in Frail, Older Persons: A Consensus Report
Abstract
The discovery of effective interventions to prevent or delay disability in older persons is a public health priority. Most likely to benefit from such interventions are frail individuals who are not yet disabled and those with early disability who are at high risk of progression. In spite of this frail older persons have often been excluded from research on the assumption that they would not tolerate testing or benefit from treatment. The Interventions on Frailty Working Group developed recommendations to screen, recruit, evaluate, and retain frail older persons in clinical trials. Specific recommendations are: Eligibility screening should include a multistage process, to quickly exclude those who are too well and those who are too sick. Inclusion criteria should target those most likely to benefit, be meaningful to clinicians, and reflect advancements in the frailty research area. Disability outcome measures should include self‐reported, objective, and proxy measures. Strategies to improve retention and compliance and to monitor their effectiveness should be an integral part of the study design. Estimation of cost and sample size should contemplate high dropout rates and interference bycompeting outcomes. Additional research is needed to refine criteria for screening frail older persons, identify objective measures of disability that are reliable and valid in frail older persons, and improve the informed consent process for high‐risk participants, recognizing that research in this subgroup is essential to improving their health outcomes.
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MethodInformation Technology for Active Ageing: A Review of Theory and Practice
Parra, C. (2014) · now publishers, Inc. eBooks · doi:10.1561/9781601989239 · Cited by 2
Kong, D., Li, X., Solomon, P., & Dong, X. (2023) · Journal of Gerontological Social Work · doi:10.1080/01634372.2023.2191124 · Cited by 2
“Hence, future studies with a broad spectrum of ADL limitations are recommended (Ferrucci et al., 2004).”
BackgroundNeuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders
Marques‐Aleixo, I., Sampaio, A., Bohn, L., Borges‐Machado, F., Barros, D. G. M., Ribeiro, Ó. M., Carvalho, J., & Magalhães, J. (2023) · Current Aging Science · doi:10.2174/1874609816666230816090934 · Cited by 2
Alfaleh, A., Alkattan, A., Alzaher, A. A., Alhabib, D., Alshatri, A., Alnamshan, A., Almalki, O. M., Almutairi, L. M., Khairat, M., Sagor, K., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110901 · Cited by 2
Paul, M., & Sarma, B. C. (2024) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2024.101632 · Cited by 2
“Other important co-factors of ADL limitation has been found to be age, since with ageing several co-morbidities happens which results in limiting disability 8, 21, 22 .”
Willers, C., Lindqvist, R., Fors, S., Mazya, A. L., Nilsson, G. H., Boström, A., & Rydwik, E. (2025) · Health Economics Review · doi:10.1186/s13561-025-00610-1 · Cited by 2
“The index was initially developed for stroke patients but has since been validated and used for broader, more heterogenous patient groups, also with regards to health economic analysis [22–25].”
Szczesna, A., Nissen, S. K., Brabrand, M., Bingisser, R. M., & Nickel, C. H. (2025) · International Journal of Clinical Practice · doi:10.1155/ijcp/2048711 · Cited by 2
“It is defned as a state with decreased reserve and limited resistance to stressors which in turn increases the risk of adverse outcomes [12–14].”
Hirabayashi, M., Kondo, S., & Katayama, N. (2020) · Global Journal of Medical Research · doi:10.34257/gjmrkvol20is11pg43 · Cited by 2
Hirabayashi, M., Kondo, S., & Katayama, N. (2020) · Global Journal of Medical Research · doi:10.34257/gjmrkvol20is11pg11 · Cited by 2
Katayma, N. (2021) · Open Access Journal of Biomedical Science · doi:10.38125/oajbs.000351 · Cited by 2
Interventies ter voorkoming van beperkingen bij thuiswonende kwetsbare ouderen;
Daniëls, R., Metzelthin, S., van Rossum, E., de Witte, L., Kempen, G. I. J. M., & van den Heuvel, W. J. (2010) · Tijdschrift voor ouderengeneeskunde · doi:10.1007/s12500-010-0005-9 · Cited by 2
Suijker, J. J., Buurman, B. M., van Rijn, M., van Dalen, M. T., ter Riet, G., van Geloven, N., de Haan, R. J., van Charante, E. P. M., & de Rooij, S. E. (2015) · Tijdschrift voor Gerontologie en Geriatrie · doi:10.1007/s12439-015-0128-2 · Cited by 2
“Uitbreiding naar een jongere (70–75 jaar) en minder kwetsbare (‘pre-frail’) populatie wordt aanbevolen om de opbrengst van preventieve interventies te verhogen [4, 6, 7, 9].”
BackgroundWagg, A. (2012) · Clinical Investigation · doi:10.4155/cli.12.68 · Cited by 2
Hoogerduijn, J. G., Weldam, S. W. M., Barneveld, R. J. V., & Schuurmans, M. J. (2013) · Journal of Nursing Education and Practice · doi:10.5430/jnep.v3n10p26 · Cited by 2
“For those at risk, a comprehensive geriatric assessment (CGA), which is focused on geriatric conditions and geriatric syndromes, should be applied, and this should be followed by targeted interventions to prevent functional decline ([25]).”
BackgroundPrevalence of Frailty Syndrome in the Elderly and Associated Factors in Brazil
Passos, A. F. M. S., Costa, Í. D. C. C., de Andrade, F. B., Eulálio, M. D. C., Neri, A. L., de Melo, R. L. P., & Lacerda, A. R. (2015) · Health · doi:10.4236/health.2015.711172 · Cited by 2
“The criteria for inclusion and exclusion were the same used in the Cardiovascular Health Study and Women’s Health and Aging Study [10] and based on studies by Fried et al. [11].”
MethodResultInfluentialBuranello, M. C., Pegorari, M. S., de Castro, S. S., & Patrizzi, L. J. (2015) · Medicina (Ribeirão Preto) · doi:10.11606/issn.2176-7262.v48i5p431-439 · Cited by 2
Cognitive performance and engagement in physical, social and intellectual activities in older adults
Sposito, G., Neri, A. L., & Yassuda, M. S. (2015) · Cited by 2
Metadata
- Authors
- Ferrucci, L., Guralnik, J. M., Studenski, S., Fried, L. P., Cutler, G. B., Walston, J. D., & The Interventions on Frailty Working Group
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2004-03-30
- Volume
- 52
- Issue
- 4
- Pages
- 625-634
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1562992882
- Cited by
- 1,027
- References
- 79
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 24 · 2023: 22 · 2022: 22 · 2021: 31 · 2020: 48 · 2019: 58 · 2018: 49 · 2017: 49 · 2016: 51 · 2015: 55 · 2014: 62 · 2013: 72 · 2012: 70
- FWCI
- 18.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Keywords
- frailty, older adults, disability prevention, functional decline, clinical trial design, participant recruitment, participant retention, sample size determination, dropout, informed consent
- MeSH terms
- Activities of Daily Living, Aged, Chronic Disease, Geriatrics, Persons with Disabilities, Health Priorities, Humans, Mass Screening, Periodicals as Topic, Planning Techniques, Primary Prevention, Public Health, Publishing, Research Design, Risk Factors, Geriatric Assessment, Randomized Controlled Trials as Topic, Frail Elderly, Outcome Assessment, Health Care, Sample Size, Disease Progression, Patient Selection
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