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Cited by 109Cardiac pacing and defibrillation studiesCardiac electrophysiology and arrhythmiasCardiovascular Syncope and Autonomic Disorders

Long-term follow-up of patients with sick sinus syndrome: a comparison of clinical aspects among unpaced, ventricular inhibited paced, and physiologically paced groups

SASAKI, YASUYUKI, SHIMOTORI, MASAHIRO, AKAHANE, KUNIO, YONEKURA, HIROAKI, HIRANO, KEN, ENDOH, RYOHEI, KOIKE, SEIICHI, KAWA, SIGEYUKI +2 more·1988·Pacing and Clinical Electrophysiology
DOI 10.1111/j.1540-8159.1988.tb06277.x
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Abstract

To analyze the prognosis of the sick sinus syndrome (SSS), we compared the clinical aspects among unpaced, ventricular paced, and physiologically paced patients who were followed over a long period. Unpaced intrinsic SSS was not always progressive and patients did not necessarily require permanent pacing. The incidence of concomitant AV conduction disturbance was 65.6% before pharmacologic autonomic block, (PAB), but this was significantly reduced to 31.7% after PAB. Follow-up study of the physiologically paced groups revealed no development of either new or more than second degree AVB. The VVI group had significantly more complications (68%) than the physiologically paced groups, mainly chronic atrial fibrillation (36%) and thromboembolism (20%). In addition, cardiothoracic ratio (CTR) in the VVI group was significantly greater compared with that in the physiologic groups. Nine deaths occurred during the follow-up period in the pacing groups, including six with VVI and three with physiologic pacing. In the VVI pacing group, heart failure and thromboembolism were most commonly the causes of death, while in the physiologic pacing groups, the causes of death were noncardiac. Although the survival rate in the ventricular paced group was not significantly different from that in the physiologic pacing groups, cardiac deaths were fewer in the latter group. Considering our clinical data, the decision to use ventricular pacing needs to be carefully weighed in patients with sick sinus syndrome, and physiologic pacing is more highly recommended.

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Crossref · 10.1111/j.1540-8159.1988.tb06277.x

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  • Cardiac pacemaker therapy is indicated and has proved effective in intrinsic sinus node disease when intermittent sinus arrest or sinoatrial block has been demonstrated to account for syncope by ECG documentation during spontaneous syncope.

    “In general, cardiac pacemaker therapy is indicated and has proved effective in intrinsic sinus node disease when intermittent sinus arrest or sinoatrial block has been demonstrated to account for syncope by means of ECG documentation during spontaneous syncope. 334-338”

    From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [338]

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Authors
SASAKI, Y., SHIMOTORI, M., AKAHANE, K., YONEKURA, H., HIRANO, K., ENDOH, R., KOIKE, S., KAWA, S., FURUTA, S., & HOMMA, T.
Affiliations
Shinshu University (JP)
Corresponding author
SASAKI, YASUYUKI
ORCID
SASAKI, YASUYUKI
Venue
Pacing and Clinical Electrophysiology
Publisher
Wiley
Published
1988-11
Volume
11
Issue
11
Pages
1575-1583
ISSN
  • 0147-8389 (ISSN-L)
  • 1540-8159
DOI
10.1111/j.1540-8159.1988.tb06277.x
OpenAlex
W2040509888
Cited by
109
References
18
Citations by year
2022: 3 · 2021: 3 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 1 · 2014: 5 · 2013: 4
FWCI
5.35
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6450 d)
Locations
  • Pacing and Clinical Electrophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Keywords
sick sinus syndrome, physiological pacing, VVI pacing, permanent cardiac pacing, atrioventricular block, atrial fibrillation, thromboembolism, heart failure, cardiovascular mortality, survival, prognosis
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cardiac Pacing, Artificial, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pacemaker, Artificial, Sick Sinus Syndrome, Time Factors

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