The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance
Open accessAbstract
Infections caused by multiresistant Gram-positive bacteria represent a major health burden in the community as well as in hospitalized patients. Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium are well-known pathogens of hospitalized patients, frequently linked with resistance against multiple antibiotics, compromising effective therapy. Streptococcus pneumoniae and Streptococcus pyogenes are important pathogens in the community and S. aureus has recently emerged as an important community-acquired pathogen. Population genetic studies reveal that recombination prevails as a driving force of genetic diversity in E. faecium, E. faecalis, S. pneumoniae and S. pyogenes, and thus, these species are weakly clonal. Although recombination has a relatively modest role driving the genetic variation of the core genome of S. aureus, the horizontal acquisition of resistance and virulence genes plays a key role in the emergence of new clinically relevant clones in this species. In this review, we discuss the population genetics of E. faecium, E. faecalis, S. pneumoniae, S. pyogenes and S. aureus. Knowledge of the population structure of these pathogens is not only highly relevant for (molecular) epidemiological research but also for identifying the genetic variation that underlies changes in clinical behaviour, to improve our understanding of the pathogenic behaviour of particular clones and to identify novel targets for vaccines or immunotherapy.
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Cites
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Waves of resistance: Staphylococcus aureus in the antibiotic era
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A Catalog of Reference Genomes from the Human Microbiome
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Vancomycin-resistant enterococci: why are they here, and where do they come from?
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Self-citationEvolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus
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“…it has recently been reported that the USA300 lineage (and its progenitor lineage USA500) acquired increased virulence through changes in expression of core virulence genes, a finding that challenges the paradigm that virulence primarily results from the acquisition of new genes (Li et al., 2009).”
High temporal and inter‐individual variation detected in the human ileal microbiota
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Cited by
The rise of the Enterococcus: beyond vancomycin resistance
Arias, C. A., & Murray, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2761 · Cited by 1,776
Exercise Attenuates PCB-Induced Changes in the Mouse Gut Microbiome
Choi, J. J., Eum, S. Y., Rampersaud, E., Daunert, S., Abreu, M. T., & Toborek, M. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306534 · Cited by 298
Glucose triggers ATP secretion from bacteria in a growth-phase-dependent manner
Hironaka, I., Iwase, T., Sugimoto, S., Okuda, K.-I., Tajima, A., Yanaga, K., & Mizunoe, Y. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03871-12 · Cited by 87
Spatial Organization of Cell Wall-Anchored Proteins at the Surface of Gram-Positive Bacteria
Dramsi, S., & Bierne, H. (2016) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2016_4 · Cited by 36
Metadata
- Authors
- Willems, R. J. L., Hanage, W. P., Bessen, D. E., & Feil, E. J.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09
- Volume
- 35
- Issue
- 5
- Pages
- 872-900
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2104657177
- Cited by
- 202
- References
- 11
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Willems, R. J. L., Hanage, W. P., Bessen, D. E., & Feil, E. J. (2011). Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance. FEMS Microbiology Reviews. https://doi.org/10.1111/j.1574-6976.2011.00284.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
