The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
Open accessAbstract
Introduction ER stress and the UPR ER stress–induced apoptosis ER stress and autophagy The UPR and neurodegenerative disease Future perspectives The stimuli for neuronal cell death in neurodegenerative disorders are multi‐factorial and may include genetic predisposition, environmental factors, cellular stressors such as oxidative stress and free radical production, bioenergy failure, glutamate‐induced excitotoxicity, neuroinflammation, disruption of Ca 2+‐regulating systems, mitochondrial dysfunction and misfolded protein accumulation. Cellular stress disrupts functioning of the endoplasmic reticulum (ER), a critical organelle for protein quality control, leading to induction of the unfolded protein response (UPR). ER stress may contribute to neurodegeneration in a range of neurodegenerative disorders. This review summarizes the molecular events occurring during ER stress and the unfolded protein response and it specifically evaluates the evidence suggesting the ER stress response plays a role in neurodegenerative disorders.
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Cites
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Cited by
A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress
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Sleep and the single neuron: the role of global slow oscillations in individual cell rest
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Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
Schönthal, A. H. (2012) · Scientifica · doi:10.6064/2012/857516 · Cited by 353
Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease
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Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy
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Metadata
- Authors
- Doyle, K. M., Kennedy, D., Gorman, A. M., Gupta, S., Healy, S. J. M., & Samali, A.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2011-09-26
- Volume
- 15
- Issue
- 10
- Pages
- 2025-2039
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W1975167087
- Cited by
- 321
- References
- 18
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Doyle, K. M., Kennedy, D., Gorman, A. M., Gupta, S., Healy, S. J. M., & Samali, A. (2011). Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. Journal of Cellular and Molecular Medicine. https://doi.org/10.1111/j.1582-4934.2011.01374.x
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