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Cited by 386Sleep and Wakefulness ResearchNeural dynamics and brain functionNeuroscience of respiration and sleep

Sleep and the single neuron: the role of global slow oscillations in individual cell rest

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Vyazovskiy, Vladyslav V., Harris, Kenneth D.·2013·Nature Reviews Neuroscience
DOI 10.1038/nrn3494PMC PMC3972489
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Abstract

Sleep is universal in animals, but its specific functions remain elusive. We propose that sleep's primary function is to allow individual neurons to perform prophylactic cellular maintenance. Just as muscle cells must rest after strenuous exercise to prevent long-term damage, brain cells must rest after intense synaptic activity. We suggest that periods of reduced synaptic input ('off periods' or 'down states') are necessary for such maintenance. This in turn requires a state of globally synchronized neuronal activity, reduced sensory input and behavioural immobility - the well-known manifestations of sleep.

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  • During human NREM sleep, the EEG exhibits low-frequency (<4 Hz) oscillatory dynamics that support memory and neural computation.

    “During human non-rapid eye movement (NREM) sleep, the electroencephalogram (EEG) exhibits low-frequency (<4 Hz) oscillatory dynamics that support memory and neural computation (1-8).”

    From Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep (2019) · cites this paper as [7]

    The Abstract describes NREM-related EEG slow waves at approximately 1–4 Hz. The Conclusions propose that slow oscillations may facilitate information processing and could enable memory consolidation, but do not establish that these dynamics support memory and neural computation specifically in humans. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Vyazovskiy, V. V., & Harris, K. D.
Affiliations
  • University of Surrey (GB)
  • UCL Queen Square Institute of Neurology (GB)
Corresponding author
  • Vyazovskiy, Vladyslav V.
  • Harris, Kenneth D.
ORCID
Vyazovskiy, Vladyslav V.
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2013-05-02
Volume
14
Issue
6
Pages
443-451
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
DOI
10.1038/nrn3494
PMC
PMC3972489
OpenAlex
W2058452561
Cited by
386
References
24
Citations by year
2026: 27 · 2025: 35 · 2024: 49 · 2023: 26 · 2022: 30 · 2021: 27 · 2020: 21 · 2019: 42 · 2018: 29 · 2017: 32 · 2016: 18 · 2015: 22 · 2014: 22 · 2013: 6
FWCI
1.78
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Wellcome Trust (095668)
  • Engineering and Physical Sciences Research Council (EP/I005102/2, EP/K015141/1, EP/I005102/1)
  • National Institute on Deafness and Other Communication Disorders (R01DC009947)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
sleep function, slow oscillations, synaptic homeostasis
MeSH terms
Animals, Cell Physiological Phenomena, Humans, Models, Biological, Neurons, Rest, Sleep, Brain Waves

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