Executive deficits in major depression
Abstract
Clinically depressed patients and control subjects were examined by means of different tests to assess executive functions (the Wisconsin Card Sorting Test, the Stroop Color Word Test and a test of verbal fluency). The results indicate that the depressed patients were generally slower than the controls, as reflected by longer retrieval times for both words and colours. Furthermore, the depressed patients showed impairment with regard to altering behaviour appropriately in response to feedback. However, there were no depression‐related increases in perseverative responses, and the ability to inhibit irrelevant information was unaffected by depression. No relationship was found between specific depressive symptoms or the severity of depression and cognitive performance. The overall pattern of results suggests that depression may affect various executive functions in a differentiated manner.
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Unmedicated depressed individuals, including children, adolescents, and adults, perform worse than healthy controls on feature-based selective attention tasks requiring attention to a task-relevant feature while ignoring a distracting feature.
“Many investigations of color-word reaction times have revealed that unmedicated depressed individuals (including children, adolescents, and adults) perform worse than healthy controls when required to attend to a task-relevant feature (e.g., color) while simultaneously ignoring a distracting feature (e.g., semantic meaning)16–19, including in an international sample of n = 1008 MDD participants”
From Paying attention to attention in depression (2019) · cites this paper as [19]
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- Authors
- Degl'Innocenti, A., Ågren, H., & Bäckman, L.
- Affiliations
- University of Gothenburg (SE)
- Karolinska Institutet (SE)
- ORCID
- Bäckman, L.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 1998-03
- Volume
- 97
- Issue
- 3
- Pages
- 182-188
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2011668290
- Cited by
- 193
- References
- 35
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 28 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 6
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, executive function, cognitive impairment, Wisconsin Card Sorting Test, Stroop task, verbal fluency, response inhibition, perseveration, feedback processing, cognitive speed, depression severity
- MeSH terms
- Analysis of Variance, Attention, Cognition Disorders, Depressive Disorder, Female, Frontal Lobe, Humans, Inhibition, Psychological, Male, Middle Aged, Neuropsychological Tests, Verbal Behavior, Volition, Case-Control Studies
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