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Cited by 231Schizophrenia research and treatmentBipolar Disorder and TreatmentMental Health and Psychiatry

The DOI matches its Crossref record; 62 of the 64 references it cites were found in a registry or an index.

Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal‐related relapse

Moncrieff, J.·2006·Acta Psychiatrica Scandinavica
DOI 10.1111/j.1600-0447.2006.00787.x
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Abstract

Objective: To examine the evidence that discontinuation of long‐term antipsychotic medication, including clozapine, may provoke a psychotic episode. Method: Databases were searched and citations scrutinised. Results: Evidence for a rapid onset psychosis (supersensitivity psychosis) following clozapine withdrawal was found and weaker evidence that this might occur with some other antipsychotic drugs. Some cases were reported in people without a psychiatric history. It appears that the psychosis may be a feature of drug withdrawal rather than the re‐emergence of an underlying illness, at least in some patients. Meta‐analyses of withdrawal studies have suggested that antipsychotic discontinuation may also increase the risk of relapse over and above the risk because of the underlying disorder, but not all individual studies show this effect. Mechanisms may relate to brain adaptations to long‐term drug use but data are sparse. Conclusion: These effects require further urgent research. Interventions to reduce morbidity after drug withdrawal need to be developed.

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Crossref · 10.1111/j.1600-0447.2006.00787.x

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  1. Franks MA, 2005, The consequences of suddenly stopping psychotropic medication in bipolar disorder, Bipolar Disorders, 4, 11
  2. 10.1345/aph.1A440 · DOI · Paper page

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Metadata

Authors
Moncrieff, J.
Affiliations
University College London (GB)
Corresponding author
Moncrieff, J.
ORCID
Moncrieff, J.
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2006-03-23
Volume
114
Issue
1
Pages
3-13
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/j.1600-0447.2006.00787.x
OpenAlex
W2168608597
Cited by
231
References
64
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 23 · 2020: 14 · 2019: 13 · 2018: 10 · 2017: 8 · 2016: 18 · 2015: 19 · 2014: 13 · 2013: 14 · 2012: 11
FWCI
1.38
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
antipsychotic withdrawal, clozapine, antipsychotic discontinuation, psychosis relapse, drug withdrawal
MeSH terms
Clozapine, Humans, Long-Term Care, Psychoses, Substance-Induced, Psychotic Disorders, Recurrence, Risk Factors, Substance Withdrawal Syndrome, Antipsychotic Agents

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