Cited by 127Mental Health Treatment and AccessAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesAging, Health, and Disability

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Mediators of the association between depression and role functioning

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Buist‐Bouwman, M. A., Ormel, J., De Graaf, R., De Jonge, P., Van Sonderen, E., Alonso, J., Bruffaerts, R., Vollebergh, W. A. M., the ESEMeD/MHEDEA 2000 investigators·2008·Acta Psychiatrica Scandinavica

DOI 10.1111/j.1600-0447.2008.01285.xPMC PMC3659780

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Abstract

Objective: While the adverse effect of Major Depressive Episode on role functioning is well established, the exact pathways remain unclear. Method: Data from The European Study of the Epidemiology of Mental Disorders, a cross‐sectional survey including 21 425 adults from six European countries, were used to assess 12‐month depression (Composite International Diagnostic Interview), activity limitations and role functioning in the past 30 days (Disability Assessment Schedule). An a priori model based on the World Health Organization’s International Classification of Functioning, Disability and Health was designed and a structural equation model for categorical and ordinal data was used (MPlus) to estimate the extent to which six limitations mediated the association between depression and role functioning. Results: The unadjusted association between depression and role functioning was strong (0.43; SE = 0.04). In the best‐fitting model, only concentration and attention problems and embarrassment mediated a significant amount of association (direct effect dropped to 0.17; SE = 0.10, which was no longer significant). Conclusions: Targeting cognition and embarrassment in treatment could help reduce depression‐associated role disfunctioning.

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Authors: Buist‐Bouwman, M. A., Ormel, J., De Graaf, R., De Jonge, P., Van Sonderen, E., Alonso, J., Bruffaerts, R., Vollebergh, W. A. M., & the ESEMeD/MHEDEA 2000 investigators
Affiliations: University Medical Center Groningen (NL)
Universitair Ziekenhuis Leuven (BE)
Utrecht University (NL)
ORCID: Ormel, J.
Alonso, J.
Bruffaerts, R.
Vollebergh, W. A. M.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2008-11-11
Volume: 118
Issue: 6
Pages: 451-458
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1111/j.1600-0447.2008.01285.x
PMC: PMC3659780
OpenAlex: W2170135777
Cited by: 127
References: 41
Citations by year: 2026: 2 · 2025: 4 · 2024: 6 · 2023: 11 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 16 · 2018: 17 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 8 · 2013: 3 · 2012: 1
FWCI: 3.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
Research portal (Tilburg University) (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
Funders: John D. and Catherine T. MacArthur Foundation (R01 DA016558, R13-MH066849)
Bristol-Myers Squibb
Eli Lilly and Company
Pfizer
GlaxoSmithKline
World Health Organization
European Commission (1999-01042, QLG5–1999-01042, SANCO2004123, 2004123)
Generalitat de Catalunya (01042)
Regione Piemonte
National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
Pfizer Foundation (R01‐MH069864, R01-DA016558, R13-MH066849)
Pan American Health Organization
Instituto de Salud Carlos III
Departament de Salut, Generalitat de Catalunya
National Institute of Mental Health (R13-MH-066849, R01‐MH070884, MH069864, MH066849, R01‐MH069864)
National Institute on Drug Abuse (K05DA015799, R01DA016558)
Fogarty International Center (FIRCA R01-TW006481, R01-TW006481, R03TW006481)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords: depression, role functioning, mediation, activity limitation, embarrassment, disability, International Classification of Functioning, Disability and Health, major depressive episode, cognitive impairment
MeSH terms: Activities of Daily Living, Adaptation, Psychological, Adolescent, Adult, Aged, Cognition Disorders, Cross-Sectional Studies, Major Depressive Disorder, Disability Evaluation, Efficiency, Europe, Health Surveys, Humans, Middle Aged, Models, Psychological, Motivation, Personality Assessment, Role, Shame, Social Environment, Cost of Illness, Young Adult

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