Cited by 20Skin and Cellular Biology ResearchDermatology and Skin DiseasesGenetic and rare skin diseases.

A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis

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Wood, John M., Schallreuter, Karin U.·2008·Experimental Dermatology

Abstract

Abstract: This review highlights the importance of enzymology, a field of great neglect in current cutaneous biology research. It was therefore the aim by using selected examples of epidermal enzymes and their action including some open questions to demonstrate the importance of this area. Clearly a thorough understanding of basic knowledge in this field is needed which in turn offers a plethora of innovative research projects for a curious mind. Moreover, in order to gain the closest understanding to the truth instead of generating esoteric results, emphasis is put forward on a holistic view utilizing a combination of modern and sometimes old methods to get the answer. Last but not least the bench work is only useful for the welfare of our patients if we can apply our basic knowledge.

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Crossref · 10.1111/j.1600-0625.2008.00754.x

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  1. Spencer J D. PhD Thesis. H 2 O 2 -mediated oxidation affects POMC- derived peptides in the human epidermis using vitiligo as a model for oxidative stress. Bradford, UK: University of Bradford, 2007.

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Authors
Wood, J. M., & Schallreuter, K. U.
Affiliations
University of Bradford (GB)
Corresponding author
Schallreuter, Karin U.
Venue
Experimental Dermatology
Publisher
Wiley
Published
2008-05-11
Volume
17
Issue
7
Pages
569-578
ISSN
  • 0906-6705 (ISSN-L)
  • 1600-0625
OpenAlex
W1976793025
Cited by
20
References
92
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2021: 2 · 2018: 1 · 2016: 3 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
0.21
Type
journal article
Language
en
Open access
Locations
  • Experimental Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
Keywords
epidermal homeostasis, skin enzymes
MeSH terms
Antioxidants, Biopterins, Calcium, Epidermis, Homeostasis, Humans, Hydrogen-Ion Concentration, Melanocytes, Neurosecretory Systems, Skin Physiological Phenomena, Keratinocytes

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