A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis
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Abstract: This review highlights the importance of enzymology, a field of great neglect in current cutaneous biology research. It was therefore the aim by using selected examples of epidermal enzymes and their action including some open questions to demonstrate the importance of this area. Clearly a thorough understanding of basic knowledge in this field is needed which in turn offers a plethora of innovative research projects for a curious mind. Moreover, in order to gain the closest understanding to the truth instead of generating esoteric results, emphasis is put forward on a holistic view utilizing a combination of modern and sometimes old methods to get the answer. Last but not least the bench work is only useful for the welfare of our patients if we can apply our basic knowledge.
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Antioxidant mechanisms work to neutralize oxidants, inhibit oxidative damage, and regulate transcription factors involved in redox and scavenging reactions.
“These mechanisms work to neutralize oxidants, inhibit oxidative damage, and regulate transcription factors involved in redox and scavenging reactions [131].”
From Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging (2016) · cites this paper as [131]
Mammalian tissues are equipped with an array of nonenzymatic and enzymatic antioxidant systems that work in a complex network to maintain the optimal level of reactive oxygen species in cells or a redox balance by several mechanisms.
“Mammalian tissues are equipped with an array of nonenzymatic and enzymatic antioxidant systems that work in a complex network to maintain the optimal level of ROS in the cells or a redox balance by several mechanisms.”
From Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging (2016) · cites this paper as [131]
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Fischer, M., Glanz, D., Urbatzka, M., Brzoska, T., & Abels, C. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00886.x · Cited by 39 · see citing works
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Choi, T., Sohn, K., Kim, J., Kim, S.-M., Kim, C., Hwang, J., Lee, J., Kim, C. D., & Yoon, T. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.280 · Cited by 29 · see citing works
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Dell’Anna, M. L., Cario, M., Bellei, B., Taı̈eb, A., & Picardo, M. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01506.x · Cited by 21 · see citing works
Yokukansan, a Traditional Japanese Medicine, Adjusts Glutamate Signaling in Cultured Keratinocytes
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The Skin and Endocrine Disorders
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Dietary Energy Levels Impact on Skin Microbiota and Metabolites of Yaks
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Impact of NAD(P)H:Quinone Oxidoreductase-1 on
Choi, P., Sohn, K., Kim, J., Kim, S.-M., Kim, C., Hwang, J., Lee, J., Kim, C. D., & Yoon, T. (2010)
Neueste Erkenntnisse und Blick in die Zukunft
Ruzicka, T., Wolff, H. J., Thomas, P. T., & Prinz, J. C. (2011) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-10358-2_1
The Skin and Endocrine Disorders
Paus, R., & Ramot, Y. (2024) · Wiley eBooks · doi:10.1002/9781119709268.rook150
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- Authors
- Wood, J. M., & Schallreuter, K. U.
- Affiliations
- University of Bradford (GB)
- Corresponding author
- Schallreuter, Karin U.
- ORCID
- Wood, John M.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2008-05-11
- Volume
- 17
- Issue
- 7
- Pages
- 569-578
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W1976793025
- Cited by
- 20
- References
- 92
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 2 · 2018: 1 · 2016: 3 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Keywords
- epidermal homeostasis, skin enzymes
- MeSH terms
- Antioxidants, Biopterins, Calcium, Epidermis, Homeostasis, Humans, Hydrogen-Ion Concentration, Melanocytes, Neurosecretory Systems, Skin Physiological Phenomena, Keratinocytes
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