The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The nature of the MHC class I peptide loading complex
Abstract
Summary: Peptide binding to major histocompatibility complex (MHC) dass I molecules occurs in the endoplasmic reticulum (ER). Efficient peptide binding requires a number of components in addition co the MHC class I‐β 2 microglobulin dimer (β 2 m). These include the two subunits of the transporter associated with antigen presentation (TAP1 and TAP2), which are essential for introducing peptides into the ER from the cytosol, and tapasin, an MHC‐encoded membrane protein. Prior to peptide binding, MHC class I‐β 2 m dimers form part of a large multisubnnit ER complex which includes TAP and tapasin. In addition to these specialized components two soluble ‘house‐keeping’ proteins, the chaperone calreticulin and the thiol oxidoreductase ERp57, are also components of this complex. Our current understanding of the nature and function of the MHC class I peptide loading complex is the topic of this review.
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Wiertz, E. J. H. J., Tortorella, D., Bogyo, M., Yu, J., Mothes, W., Jones, T. R., Rapoport, T. A., & Ploegh, H. L. (1996) · Nature · doi:10.1038/384432a0 · Cited by 1,105
Bole, D. G., Hendershot, L. M., & Kearney, J. F. (1986) · The Journal of cell biology · doi:10.1083/jcb.102.5.1558 · Cited by 876
Sadasivan, B., Lehner, P. J., Ortmann, B., Spies, T., & Cresswell, P. (1996) · Immunity · doi:10.1016/s1074-7613(00)80487-2 · Cited by 700
Self-citationQuality control in the secretory pathway
Hammond, C., & Helenius, A. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80009-3 · Cited by 673
A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes
Ortmann, B., Copeman, J., Lehner, P. J., Sadasivan, B., Herberg, J. A., Grandea, A. G., Riddell, S. R., Tampé, R., Spies, T., Trowsdale, J., et al. (1997) · Science · doi:10.1126/science.277.5330.1306 · Cited by 525
Self-citationER Quality Control: The Cytoplasmic Connection
Kopito, R. R. (1997) · Cell · doi:10.1016/s0092-8674(00)81881-4 · Cited by 518
Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding
Roche, P. A., & Cresswell, P. (1990) · Nature · doi:10.1038/345615a0 · Cited by 492
Self-citationInteraction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins
Oliver, J. D., van der Wal, F. J., Bulleid, N. J., & High, S. (1997) · Science · doi:10.1126/science.275.5296.86 · Cited by 390
Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90)
Jackson, M. R., Cohen-Doyle, M. F., Peterson, P. A., & Williams, D. B. (1994) · Science · doi:10.1126/science.8278813 · Cited by 355
MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding
Ortmann, B., Androlewicz, M. J., & Cresswell, P. (1994) · Nature · doi:10.1038/368864a0 · Cited by 353
Self-citation
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Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
Glycosylation and the Immune System
Rudd, P. M., Elliott, T., Cresswell, P., Wilson, I. A., & Dwek, R. A. (2001) · Science · doi:10.1126/science.291.5512.2370 · Cited by 1,588
Self-citationDifferential Antigen Processing by Dendritic Cell Subsets in Vivo
Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H.-W., Park, C. G., et al. (2007) · Science · doi:10.1126/science.1136080 · Cited by 1,455
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation
Dhatchinamoorthy, K., Colbert, J. D., & Rock, K. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.636568 · Cited by 1,077
Roles of heat-shock proteins in innate and adaptive immunity.
Srivastava, P. (2002) · Nature reviews. Immunology · doi:10.1038/nri749 · Cited by 1,069
Metadata
- Authors
- Cresswell, P., Bangia, N., Dick, T., & Diedrich, G.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 1999-12
- Volume
- 172
- Issue
- 1
- Pages
- 21-28
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2075908603
- Cited by
- 332
- References
- 44
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
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