Autophagy proteins regulate cell engulfment mechanisms that participate in cancer
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Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.
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Once engulfed, entotic cells are often eliminated by a RCD subroutine independent of BCL2 proteins and caspases, but relying at least in part on LC3-associated phagocytosis.
“Once engulfed, entotic cells are often eliminated by a RCD subroutine that occurs independently of BCL2 proteins and caspases [694, 704], but relies (at least in part) on a specific autophagy-related process commonly known as LC3-associated phagocytosis (LAP) [509, 705, 706].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [705]
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Pitfalls in methods to study colocalization of nanoparticles in mouse macrophage lysosomesPreprint
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- Authors
- Kim, S. E., & Overholtzer, M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Overholtzer, Michael
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 23
- Issue
- 5
- Pages
- 329-336
- ISSN
- 1044-579X (ISSN-L)
- PMC
- PMC3791149
- OpenAlex
- W2013691131
- Cited by
- 35
- References
- 99
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 3 · 2013: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Cancer Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA154649, CA154649)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- autophagy-related proteins, LC3-associated phagocytosis, cell engulfment, phagosome, lysosome fusion, LC3 lipidation, carcinogenesis, cancer, phagocytosis inhibition
- MeSH terms
- Animals, Autophagy, Humans, Lysosomes, Neoplasms, Phagocytosis, Phagosomes, Proteins, Carcinogenesis
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